A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

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Check availability on Mytilene Resorts & Hotels with Spas

This weekend
Oct 30 - Nov 1
Next weekend
Nov 6 - Nov 8

Our top choices for Mytilene hotels with a spa

A hotel lobby with a reception desk, a sofa, a chair, and a dining area.

1. Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel
4.0 star property
Lesvos
9.6 out of 10, Exceptional, (175 reviews)
  • cleanliness
    Escape to a boutique spa retreat with hot springs and massage therapy in the heart of Mytilene.
The price is ￥17,357
￥20,771 total
includes taxes & fees
Oct 30 - Oct 31
Theofilos Paradise Boutique Hotel
Two wicker chairs with cushions, a decorative plant, and a small round table with candles and a tray.

2. Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat
5.0 star property
Lesvos
8.6 out of 10, Excellent, (72 reviews)
  • cleanliness
    Relax in a coastal spa haven with hydrotherapy, hot springs, and three indoor pools for ultimate rejuvenation.
The price is ￥13,324
￥15,300 total
includes taxes & fees
Nov 1 - Nov 2
Mythical Coast Wellness Retreat
A person standing on a balcony overlooking a pool and a modern building with a clear view of the sea.

3. Elysion Hotel

Elysion Hotel
5.0 star property
Lesvos
9.2 out of 10, Wonderful, (51 reviews)
  • cleanliness
    Immerse in a rejuvenating Greek island escape with tennis courts, seasonal pools, and serene balconied rooms overlooking Lesvos.
The price is ￥14,949
￥17,079 total
includes taxes & fees
Nov 5 - Nov 6
Elysion Hotel
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

4. Elies Residences

Elies Residences
Lesvos
9.8 out of 10, Exceptional, (38 reviews)
  • cleanliness
    Relax in premium villas with spa treatments and outdoor pool in this serene getaway.
The price is ￥16,465
￥18,124 total
includes taxes & fees
Nov 2 - Nov 3
Elies Residences
A balcony with a view of the sea, a seating area, and a bed with pillows.

5. Olive Green Studios and Apartments

Olive Green Studios and Apartments
Lesvos
10.0 out of 10, Exceptional, (6 reviews)
  • cleanliness
    Rejuvenating seaside retreat offers in-room massages and a tranquil garden sanctuary, perfect for a wellness escape by the beach.
The price is ￥11,927
￥13,417 total
includes taxes & fees
Oct 29 - Oct 30
Olive Green Studios and Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Mytilene

Pool
Breakfast included

Top Mytilene Hotel Reviews

Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel

8/10 Good
"Staff was nice. Large breakfast spread. Location is great."
Caroline 1-night trip
Posted 3 months ago
Theofilos Paradise Boutique Hotel

Frequently asked questions

Looking to vacation at a spa hotel in Mytilene?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Check out the museums and churches in Mytilene—your cultural tour starts here. Enjoy the architecture and sea views during your vacation. Spa hotels are a great way to break out of your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Mytilene?
Mythical Coast Wellness Retreat is a top beach spa hotel featuring 5 restaurants, 5 bars, 3 indoor pools, and 5 cafes. Treat yourself to a facial, body scrub, or Swedish massage at Mythical Coast Spa. Another popular spa hotel in Mytilene is Theofilos Paradise Boutique Hotel.
How many spa hotels are there in Mytilene?
Among Expedia's 88 accommodation options in Mytilene, there are 2 spa hotels.
What's there to see and do in Mytilene?
When you're in Mytilene, enjoy exploring the sights and attractions here including Port of Mytilene, Mytilini Castle, and Roman Aqueduct at Moria. If you have a bit of extra time while you're in the area, you might want to check out Thermes Gera Hot Springs and St Hermogenes Charamida Lesvos.
What is a Mytilene spa hotel?
Spa hotels in Mytilene feature full on-site spas offering services like facials and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your vacation.