Find hotels near Medi Center, San Diego from ￥8,730

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Dec 27 - Dec 28
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Dec 28 - Dec 29
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Our top choices for Medi Center hotels

Sanctuary 4 Bedroom Historic Church | In-room dining
Good Life Vacation Rental Resort

Good Life Vacation Rental Resort

Good Life Vacation Rental Resort
2.0 star property
1.7 km from Medi Center
9.4 out of 10, Exceptional, (32)
"The area around the property is old, but felt totally safe inside the property. Inside was very nice! Would stay again!"
United States
Jamie
Good Life Vacation Rental Resort
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Lodge at 32nd

Lodge at 32nd

Lodge at 32nd
2.5 star property
1.8 km from Medi Center
7.6 out of 10, Good, (801)
"Great place for the money "
United States
Isabel
The price is ￥11,631
￥14,874 total
includes taxes & fees
Dec 28 - Dec 29
Lodge at 32nd
Free daily continental breakfast
Quality Inn San Diego I-5 Naval Base

Quality Inn San Diego I-5 Naval Base

Quality Inn San Diego I-5 Naval Base
2.5 star property
3.2 km from Medi Center
7.8 out of 10, Good, (877)
"Everything was really fine!"
United States
Sebastian Alejandro
The price is ￥14,655
￥16,552 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Quality Inn San Diego I-5 Naval Base
Memory foam beds, blackout drapes, iron/ironing board, free WiFi
Stay Classy Hostel

Stay Classy Hostel

Stay Classy Hostel
2.0 star property
East Village, 4.2 km from Medi Center
9.6 out of 10, Exceptional, (788)
"Good place to stay "
United States
sai
Stay Classy Hostel
Premium bedding, pillowtop beds, desk, laptop workspace
Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

Sentral Gaslamp Quarter
4.0 star property
East Village, 4.6 km from Medi Center
9.2 out of 10, Wonderful, (609)
"Everything was splendid. Very friendly staff as well. "
United States
Irving
The price is ￥17,121
￥24,375 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Sentral Gaslamp Quarter
Standard Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board
Rodeway Inn National City San Diego South

Rodeway Inn National City San Diego South

Rodeway Inn National City San Diego South
2.0 star property
3.8 km from Medi Center
6.6 out of 10, (225)
"Pretty good "
United States
Ray
The price is ￥10,485
￥11,533 total
includes taxes & fees
Dec 30 - Dec 31
Rodeway Inn National City San Diego South
Rooftop terrace
Porto Vista Hotel Downtown

Porto Vista Hotel Downtown

Porto Vista Hotel Downtown
3.5 star property
Little Italy, 5.9 km from Medi Center
6.8 out of 10, (1201)
"Nice stay, staff excellent, friendly, helpful and great customer service. Hotel ok older"
United States
Mizael
The price is ￥13,537
￥16,558 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Porto Vista Hotel Downtown
Suite, 1 King Bed with Sofa bed, City View | View from room
Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
4.9 km from Medi Center
9.4 out of 10, Exceptional, (1004)
"The hotel and staff are amazing!"
United States
Barbara
The price is ￥24,895
￥28,864 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Marriott Vacation Club®, San Diego
Lobby sitting area
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
4.0 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.2 out of 10, Wonderful, (2049)
"Very comfortable, nice location and good service "
United States
ALEXANDER
The price is ￥30,394
￥42,302 total
includes taxes & fees
Dec 28 - Dec 29
Omni San Diego Hotel at the Ballpark
In-room safe, desk, laptop workspace, iron/ironing board
Holiday Inn Express San Diego South - National City by IHG

Holiday Inn Express San Diego South - National City by IHG

Holiday Inn Express San Diego South - National City by IHG
2.5 star property
4.2 km from Medi Center
8.4 out of 10, Very Good, (1003)
"It was very nice"
United States
JOSEPH
The price is ￥17,223
￥18,979 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express San Diego South - National City by IHG
3 restaurants, breakfast, lunch, dinner served; seafood
Pendry San Diego

Pendry San Diego

Pendry San Diego
5.0 star property
Gaslamp Quarter, 5 km from Medi Center
9.2 out of 10, Wonderful, (1003)
"Excellent Stay at Pendry - will definitely return when visiting San Diego"
Canada
Bobbi Jo
The price is ￥42,939
￥57,991 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Pendry San Diego
Exterior
Hotel Indigo San Diego-Gaslamp Quarter by IHG

Hotel Indigo San Diego-Gaslamp Quarter by IHG

Hotel Indigo San Diego-Gaslamp Quarter by IHG
4.0 star property
East Village, 4.7 km from Medi Center
8.8 out of 10, Excellent, (1004)
"Large, comfy room, good service, good location"
United States
Thanapong
The price is ￥22,546
￥31,950 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hotel Indigo San Diego-Gaslamp Quarter by IHG
Standard Quadruple Room, Mixed Dorm | Shared kitchen facilities | Shared fridge, microwave, stovetop, toaster
Gaslamp Hostel

Gaslamp Hostel

Gaslamp Hostel
2.0 star property
Gaslamp Quarter, 5.1 km from Medi Center
9.2 out of 10, Wonderful, (539)
"Great location with clean, comfortable rooms. Amazing ambiance and professional staff. I would stay hear again."
United States
Anthony Michael
Gaslamp Hostel
Exterior
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
4.0 star property
Gaslamp Quarter, 5.1 km from Medi Center
9.2 out of 10, Wonderful, (632)
"Great stay"
United States
Angelica
The price is ￥24,895
￥28,864 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
View from property
San Diego Downtown Lodge

San Diego Downtown Lodge

San Diego Downtown Lodge
2.0 star property
4.7 km from Medi Center
6.2 out of 10, (1003)
"The staff are really nice here. A convenient location. "
United States
Emmanuel
San Diego Downtown Lodge
View from property
Moxy San Diego Downtown/Gaslamp Quarter

Moxy San Diego Downtown/Gaslamp Quarter

Moxy San Diego Downtown/Gaslamp Quarter
3.5 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.0 out of 10, Wonderful, (1001)
"The staff was amazing, friendly, helpful and attentive. "
United States
Jan
The price is ￥17,725
￥21,956 total
includes taxes & fees
Dec 29 - Dec 30
Moxy San Diego Downtown/Gaslamp Quarter
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.0 out of 10, Wonderful, (1173)
"Amenities and location were great. "
United States
Julie
The price is ￥26,633
￥37,233 total
includes taxes & fees
Dec 28 - Dec 29
Margaritaville Hotel San Diego Gaslamp Quarter
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 5 km from Medi Center
9.0 out of 10, Wonderful, (1238)
"Clean, courteous staff, good location. "
United States
Carla
The price is ￥14,221
￥16,488 total
includes taxes & fees
Dec 29 - Dec 30
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Gaslamp Quarter, 5 km from Medi Center
9.0 out of 10, Wonderful, (3163)
"Beautiful hotel"
United States
Jordan M.
The price is ￥23,673
￥34,650 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hard Rock Hotel San Diego
Desk, free WiFi, bed sheets
Motel 6 San Diego, CA - Downtown

Motel 6 San Diego, CA - Downtown

Motel 6 San Diego, CA - Downtown
2.0 star property
5.4 km from Medi Center
6.2 out of 10, (1232)
"Great space and ease of access"
United States
Darren
The price is ￥7,253
￥8,730 total
includes taxes & fees
Dec 29 - Dec 30
Motel 6 San Diego, CA - Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Medi Center Hotel Reviews

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

10/10 Excellent
"Best place to stay with family in San diego"
vishakha 3-night trip
Posted 2 days ago
Marriott Marquis San Diego Marina

Hotels near other Medi Center attractions

Nu-Way Christian Ministries

Find out about the history of San Diego when you take a trip to Nu-Way Christian Ministries.
See properties

Pilgrim Progressive Baptist Church

Pilgrim Progressive Baptist Church is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels?
See properties

Frequently asked questions

What's the area like around Medi Center?
Medi Center is located in San Diego. If you're looking for a convenient place to stay, check out the 26 hotels and other accommodations you'll find within a mile.
What's the best place to stay near Medi Center?
Lodge at 32nd is one of the top choices for your stay based on our traveler data, and this hotel offers free parking and a snack bar/deli. It's located 1.1 mi (1.8 km) from Medi Center. Other good options within a few miles include Good Life Vacation Rental Resort and Hard Rock Hotel San Diego.
How many hotels will I be able to find near Medi Center?
Expedia has 26 hotels and other accommodations within a mile from Medi Center.
If I need to cancel the hotel reservation for my stay near Medi Center, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals available near Medi Center.
Where can I learn more about changing or cancelling my trip in the area near Medi Center?
To access more information about changing or cancelling your stay near Medi Center, click here.
What can I see and do near Medi Center?
San Diego Natural History Museum, San Diego Museum of Art, and San Diego Air and Space Museum feature a variety of fascinating exhibits to see while you're in town. Hotel del Coronado, California Tower, and Star of India are some of the notable landmarks to see in the area. You can watch performances at Old Globe Theater, San Diego Civic Theatre, and The Rady Shell at Jacobs Park if you're interested in local theater.