Lake Nona Medical City Vacations from ￥256,434

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The Latest Lake Nona Medical City Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Delaney Hotel

The Delaney Hotel

3.5 out of 5
South Orange
Price was ￥327,944, price is now ￥256,434 per person
￥256,434
per person
May 21 - May 27
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to Orlando (MCO)
9.6/10 Exceptional! (1,062 reviews)
Very Clean rooms and modernized

Reviewed on Feb 25, 2026

Margaritaville Cottages Orlando by Vstays with H2O Waterpark

Margaritaville Cottages Orlando by Vstays with H2O Waterpark

4 out of 5
Price was ￥535,596, price is now ￥397,909 per person
￥397,909
per person
Apr 11 - Apr 17
found 5 hours ago
Roundtrip flight included
Tokyo (HND) to Orlando (MCO)
9.2/10 Wonderful! (1,000 reviews)
Everything was excellent. Beautiful house that was spotless.

Reviewed on Feb 22, 2026

Florida Hotel & Conference Center in the Florida Mall

Florida Hotel & Conference Center in the Florida Mall

3.5 out of 5
Price was ￥326,738, price is now ￥266,664 per person
￥266,664
per person
May 21 - May 27
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to Orlando (MCO)
9.2/10 Wonderful! (2,232 reviews)
Room was clean. Nice lobby. Pool area could use a bit of a clean up.

Reviewed on Feb 28, 2026

Ramada Plaza Resort & Suites by Wyndham Orlando Intl Drive

Ramada Plaza Resort & Suites by Wyndham Orlando Intl Drive

3 out of 5
International Drive District
Price was ￥392,653, price is now ￥324,390 per person
￥324,390
per person
Apr 11 - Apr 17
found 5 hours ago
Roundtrip flight included
Tokyo (HND) to Orlando (MCO)
7.8/10 Good! (374 reviews)
Overall comfortable stay but the breakfast can use a whole new make over. Add more options for meats and hot foods. Pastries won’t hurt.

Reviewed on Mar 3, 2026

Vista Cay by Orlando Resort Rentals on Universal Boulevard

Vista Cay by Orlando Resort Rentals on Universal Boulevard

3.5 out of 5
Price was ￥328,224, price is now ￥278,351 per person
￥278,351
per person
May 21 - May 27
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to Orlando (MCO)
9.4/10 Exceptional! (843 reviews)
We loved the space of 4102 #107. It was perfect for the us and our daughter. The main hot tub didn’t work while we were there but we were so able to enjoy the two pools and hot tub on the newer side of the resort. Adam, the pool bartender, was absolutely amazing! Super friendly & made great drinks.

Reviewed on Mar 2, 2026

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona Medical City
International Drive showing landscape views

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Find hotels in International Drive District

Lake Nona Medical City Hotel Deals

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4 out of 5
8800 Vistana Centre Dr Orlando FL
Fully refundableReserve now, pay when you stay
The price is ￥20,474 per night from Mar 23 to Mar 24
￥20,474
￥23,033 total
Mar 23 - Mar 24
includes taxes & fees
9.2/10 Wonderful! (4,751 reviews)
The grounds were beautiful! And our room was very spacious! We were just there for one night, so didn’t get to really experience it, but it was a lovely stay.

Reviewed on Mar 3, 2026

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

4 out of 5
5780 Major Blvd Orlando FL
Fully refundableReserve now, pay when you stay
The price is ￥16,636 per night from Mar 29 to Mar 30
￥16,636
￥18,716 total
Mar 29 - Mar 30
includes taxes & fees
8.4/10 Very Good! (6,873 reviews)
There is only one small place to buy coffee in the morning with many,many people in line. It would be helpful to have coffee available in the lobby or a larger coffee shop.

Reviewed on Mar 3, 2026

DoubleTree by Hilton at the Entrance to Universal Orlando
Vacation Village Orlando, Celebration

Vacation Village Orlando, Celebration

3 out of 5
2975 Arabian Nights Blvd Kissimmee FL
Fully refundableReserve now, pay when you stay
The price is ￥13,904 per night from Mar 22 to Mar 23
￥13,904
￥19,682 total
Mar 22 - Mar 23
includes taxes & fees
8.6/10 Excellent! (3,515 reviews)
Large kitchen, clean, staff was amazing! Not as sound proof as other hotels but overall amazing and great value for the price!

Reviewed on Mar 2, 2026

Vacation Village Orlando, Celebration
See all 27,176 properties in Lake Nona Medical City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Lake Nona Medical City vacation package cost?
The cheapest Lake Nona Medical City package is ￥256,434, so your dream trip can become a reality — without burning a hole in your pocket. Combine flights, hotels and car rentals to tailor make a package that suits your travel style.
How do I get a cheap travel package to Lake Nona Medical City?
Find flights that fit your busy schedule, add a hotel to your booking and watch the savings rack up with a Lake Nona Medical City vacation package. It's as easy as that! From flights and hotels to tours and rental cars, Expedia makes traveling cheap and easy. And with more than 550 air carriers and 1,000,000 hotel options globally to pick from, you won't be short of choice.
Where should I stay in Lake Nona Medical City?
With loads to explore in Lake Nona Medical City, it'd be convenient for you to stay close to its attractions. Nemours Childrens Hospital, VA Medical Center at Lake Nona and University of Central Florida College of Medicine are some fascinating ones to add to your to-do list.
What are the top hotels in Lake Nona Medical City?
Make a reservation at Residence Inn Orlando Lake Nona. It's one of the area's most sought-after properties. Another reputable option in Lake Nona Medical City is Courtyard Orlando Lake Nona.
How far in advance should I book my Lake Nona Medical City vacation?
It depends on the airline, but you can generally look up international fares on Expedia up to a year in advance. While it's generally a good idea to book ahead of time, lucky customers occasionally score a cheaper ticket just weeks prior to the date of departure.
What does an Expedia Lake Nona Medical City travel package include?
Expedia has everything you need to organize your Lake Nona Medical City getaway, but what goes into your package is totally up to you. Choose from a combination of hotels, rental cars and flights. In search of some experiences or tours to keep you busy? Once you've made your booking, you can add them too. Whatever your budget or style, there's a deal to match your needs.
What should I know before booking a Lake Nona Medical City travel package?
Locking in all the parts of your escape together is a great way to save. Combine your airfares, rental cars and hotels into one package. But hotels aren't your only option. Expedia has all types of properties, including vacation rentals like beachside villas and city apartments. The list goes on!
Can I choose my airline with a Lake Nona Medical City Expedia vacation package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines worldwide. Our vacation packages give you the freedom to take your pick of available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my Lake Nona Medical City vacation package?
Don't worry if you're rethinking your Lake Nona Medical City vacation package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it at no cost. However, bookings made more than 24 hours ago may incur a fee from your airline, hotel or car rental company. We know life can throw the occasional spanner in the works, so look up our Customer Service Portal if that occurs. When you're ready to make changes, we'll be here to help.

Discover the most popular places to visit in Lake Nona Medical City

University of Central Florida College of Medicine

5/5(1 review)

Enjoy the collegiate vibe at University of Central Florida College of Medicine as part of your travels around Orlando. Stroll along the seaside in this family-friendly area, or check out its top-notch restaurants.

University of Central Florida College of Medicine

Sanford-Burnham Medical Research Institute

5/5(1 review)

Though Sanford-Burnham Medical Research Institute might be what brings you to town, perhaps you'll have a chance to explore more of Orlando while you are here.

Sanford-Burnham Medical Research Institute

Things to do

Universal Orlando Resort Express Passes

Universal Orlando Resort Express Passes

￥29,886
per traveler
82% of travellers recommend
Universal Orlando Resort Express Passes
Universal Orlando Resort

Universal Orlando Resort Theme Park Tickets

￥25,302
per adult
78% of travellers recommend
Universal Orlando Resort Theme Park Tickets
Aquatica Orlando

Aquatica Orlando

￥8,251
per traveler
84% of travellers recommend
Aquatica Orlando
See all activities in Orlando
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.