Photo by Michele Butts

La Mesa Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Nov 21 - Nov 23
In two months
Jan 2 - Jan 4
In three months
Jan 30 - Feb 1
In four months
Feb 27 - Mar 1

Vacation Rentals in La Mesa

Property grounds
Beautiful NEW One Bedroom Studio in San Diego (Mt. Helix)

Beautiful NEW One Bedroom Studio in San Diego (Mt. Helix)

Mount Helix
10.0 out of 10, Exceptional, (4)
"Cindy was and amazing host and answer my questions promptly. The studio is well equipped for quick meals and the bathroom is upscale. All the appointments and finishes are as advertised and would stay again."
United States
Stephen M.
The price is ￥20,574
￥36,069 total
includes taxes & fees
Nov 9 - Nov 10
Beautiful NEW One Bedroom Studio in San Diego (Mt. Helix)
Living area
Sunnyside Resort Spa, Beach, Zoo, Arcade

Sunnyside Resort Spa, Beach, Zoo, Arcade

2.0 star property
La Mesa
9.6 out of 10, Exceptional, (14)
"It was nice "
United States
Aaronino 7.
The price is ￥26,169
￥60,770 total
includes taxes & fees
Nov 11 - Nov 12
Sunnyside Resort Spa, Beach, Zoo, Arcade
Fridge, microwave, oven, stovetop
4BR/3Bth King Bed, Big Yard, Prime Area, Ranch

4BR/3Bth King Bed, Big Yard, Prime Area, Ranch

La Mesa
8.0 out of 10, Very Good, (1)
"Check-in was easy. The neighborhood felt very safe and was quiet. Every type of shopping is nearby; from groceries to shoes. Local restaurants are abundant! LaMesa Bistro and Centifontis serve delicious food. The unit is spacious, especially the kitchen. There is A/C in each bedroom and the living room. Teenagers enjoyed playing the PS4 that is in the bedroom with the high windows where the picture shows a desk. We enjoyed our coffee early in the morning beneath the balcony of the upstairs...
United States
Karen Z.
The price is ￥16,931
￥64,190 total
includes taxes & fees
Nov 11 - Nov 12
4BR/3Bth King Bed, Big Yard, Prime Area, Ranch
Fridge, microwave, oven, stovetop
Designer Poolside 1Bed1Bth Retreat

Designer Poolside 1Bed1Bth Retreat

La Mesa
8.8 out of 10, Excellent, (6)
"Perfect spot in a beautiful neighborhood."
United States
Mary A.
The price is ￥20,786
￥49,082 total
includes taxes & fees
Nov 9 - Nov 10
Designer Poolside 1Bed1Bth Retreat
Fridge, oven, stovetop, coffee/tea maker
An elegant, fully furnished guest house for 2-4 guest in San Diego

An elegant, fully furnished guest house for 2-4 guest in San Diego

Mount Helix
9.0 out of 10, Wonderful, (2)
"We love a simple no-nonsense place and this was perfect for us. The host is very responsive and was constantly checking in with us on what else we need to be comfortable to stay here. The area is close a lot of nice restaurants so that was a plus. We would love to stay here next time we visit San Diego."
United States
Darakhshan T.
The price is ￥34,520
￥44,607 total
includes taxes & fees
Nov 9 - Nov 10
An elegant, fully furnished guest house for 2-4 guest in San Diego
Fridge, microwave, oven, stovetop
SDSU/Downtown <10 Min - GameRoom - Fire Pit - Free Parking - Easy Freeway Access

SDSU/Downtown <10 Min - GameRoom - Fire Pit - Free Parking - Easy Freeway Access

La Mesa
10.0 out of 10, Exceptional, (1)
"We stayed at this beautiful VRBO for our child’s college graduation in San Diego, and it couldn’t have been more perfect. The home was spotless, spacious, and exactly as described—if not better! Every room was thoughtfully appointed, and the beds were incredibly comfortable. The kitchen had everything we needed to cook family meals, and we loved gathering in the common areas to celebrate and relax.The location was ideal—close to the campus and shopping.Our host was responsive, welcoming, and...
United States
Michele G.
The price is ￥33,802
￥69,133 total
includes taxes & fees
Nov 17 - Nov 18
SDSU/Downtown <10 Min - GameRoom - Fire Pit - Free Parking - Easy Freeway Access
Terrace/patio
Private Pool, Chef’s Kitchen, BBQ - 4min to SDSU

Private Pool, Chef’s Kitchen, BBQ - 4min to SDSU

La Mesa
10.0 out of 10, Exceptional, (15)
"Our stay was amazing. All the amenities you want in a great location close to SDSU so we could move out our student "
United States
Sonja G.
The price is ￥54,961
￥88,151 total
includes taxes & fees
Dec 3 - Dec 4
Private Pool, Chef’s Kitchen, BBQ - 4min to SDSU
Private kitchen
Sunset Mesa • Spa• Ac • 10+ Guests •Theatre• Downtown• Beach • 3 Bed/2 Bath

Sunset Mesa • Spa• Ac • 10+ Guests •Theatre• Downtown• Beach • 3 Bed/2 Bath

La Mesa
Sunset Mesa • Spa• Ac • 10+ Guests •Theatre• Downtown• Beach • 3 Bed/2 Bath
Pool
Luxury 5BR Villa - Pool, Spa, Movie Theater, Game Room, Bar, & Outdoor Dining

Luxury 5BR Villa - Pool, Spa, Movie Theater, Game Room, Bar, & Outdoor Dining

2.0 star property
Mount Helix
The price is ￥107,394
￥311,136 total
includes taxes & fees
Nov 9 - Nov 10
Luxury 5BR Villa - Pool, Spa, Movie Theater, Game Room, Bar, & Outdoor Dining
Outdoor dining
Private Casita • No Extra Fees • Spa • Beach • AC

Private Casita • No Extra Fees • Spa • Beach • AC

La Mesa
Private Casita • No Extra Fees • Spa • Beach • AC
Deluxe Studio, 1 Queen Bed (Self Check-in with Virtual Front Desk) | Individually decorated, individually furnished, laptop workspace
Kasa Gaslamp Quarter San Diego

Kasa Gaslamp Quarter San Diego

3.5 star property
Downtown San Diego
8.0 out of 10, Very Good, (144)
"Plenty of restaurants all in walking distance. Given the area of the room could be quieter but other than that it was a very nice stay"
United States
Melisa
The price is ￥13,193
￥15,033 total
includes taxes & fees
Nov 26 - Nov 27
Kasa Gaslamp Quarter San Diego
Premium bedding, pillowtop beds, desk, laptop workspace
Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (527)
"Are stay was great . "
United States
Pedro
The price is ￥20,259
￥27,936 total
includes taxes & fees
Nov 9 - Nov 10
Sentral Gaslamp Quarter
Microwave, oven, stovetop, dishwasher
Million Dollar Ocean Views! Central Location & Parking

Million Dollar Ocean Views! Central Location & Parking

Point Loma
9.8 out of 10, Exceptional, (25)
"Very clean, great location. Friendly host, easy check in."
United States
Lona M.
The price is ￥16,404
￥37,553 total
includes taxes & fees
Nov 11 - Nov 12
Million Dollar Ocean Views! Central Location & Parking
Fridge, microwave, oven, stovetop
'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!

'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!

2.0 star property
Encanto
8.8 out of 10, Excellent, (30)
"Enjoyed my stay"
United States
BJ
The price is ￥11,930
￥34,215 total
includes taxes & fees
Nov 16 - Nov 17
'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!
Outdoor pool, a heated pool
Wave Crest Resort

Wave Crest Resort

3.0 star property
Del Mar
9.2 out of 10, Wonderful, (136)
"Great stay"
United States
Zhyan Jay
The price is ￥30,862
￥40,075 total
includes taxes & fees
Nov 16 - Nov 17
Wave Crest Resort
Exterior
City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills

4.5 star property
Middletown
9.6 out of 10, Exceptional, (98)
"Great place to stay with my family of 9!!!"
United States
Erica
City24 Hotel Little Italy Mission Hills
Interior
3bd with TV and AC, 2 air mattress, 2ba, 15-20 minute to everything in San Diego

3bd with TV and AC, 2 air mattress, 2ba, 15-20 minute to everything in San Diego

Mount Hope
10.0 out of 10, Exceptional, (19)
"It was a great time and the host was extremely responsive. "
United States
Ubaldo G.
The price is ￥38,355
￥77,017 total
includes taxes & fees
Nov 14 - Nov 15
3bd with TV and AC, 2 air mattress, 2ba, 15-20 minute to everything in San Diego
Terrace/patio
Cozy Pacific Beach Cottage w/Bikes, Private Yard & Entrance

Cozy Pacific Beach Cottage w/Bikes, Private Yard & Entrance

Pacific Beach
9.6 out of 10, Exceptional, (54)
"Nice, cute cottage. Would definitely stay again. "
United States
Linda P.
The price is ￥18,257
￥36,781 total
includes taxes & fees
Dec 2 - Dec 3
Cozy Pacific Beach Cottage w/Bikes, Private Yard & Entrance
Sun loungers, beach towels
Villa Serena- full kitchen, and just a 3 minute walk to the beach!

Villa Serena- full kitchen, and just a 3 minute walk to the beach!

Beach Barber Tract
9.6 out of 10, Exceptional, (36)
"Great place. I plan on staying there again in the future "
United States
Ron C.
The price is ￥15,342
￥33,953 total
includes taxes & fees
Nov 11 - Nov 12
Villa Serena- full kitchen, and just a 3 minute walk to the beach!
Exterior detail
Cozy Private Studio in El Cajon

Cozy Private Studio in El Cajon

Mount Helix
8.6 out of 10, Excellent, (19)
"Overwhelmingly comfortable."
United States
omar r.
The price is ￥11,737
￥14,805 total
includes taxes & fees
Nov 9 - Nov 10
Cozy Private Studio in El Cajon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesa Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"The staff was great and they had continental breakfast with is always a plus. "
Migdalia 1-night trip
Posted 1 day ago
Hampton Inn & Suites by Hilton San Diego SeaWorld

Find out more about La Mesa

Search for holiday rentals in La Mesa on Expedia! You can easily find your home rentals, villas, holiday apartments in La Mesa using one of the methods below:

  • View our selection of featured holiday rentals in La Mesa
  • Use the map to find apartments and other holiday homes in the La Mesa neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in La Mesa while they last

Look no further and take a look at our great range of rental properties in La Mesa!

Frequently asked questions

Are there vacation rentals in La Mesa?

Yes, you can find vacation rentals in La Mesa near Computer Museum of America, or you can choose a secluded option if you'd like a relaxing place to stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

What are some of the best vacation rentals that La Mesa has to offer?

Spanish Casita in the Village of La Jolla - Walk to Everything: Visitors like this La Mesa vacation home rental. It is located near the beach and has a balcony, a selection of games, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a fridge, a microwave, and an electric kettle.

How many vacation rentals are there in La Mesa?

With 112 Expedia vacation rentals, you're sure to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

Explore the area and cultural attractions such as Computer Museum of America, or visit a family-friendly sight such as San Diego Zoo. While in the area, you can also visit popular places like Mission Bay and Petco Park.

What are vacation rentals like in La Mesa?

Vacation rentals are privately owned properties you can book for several days or more in La Mesa. Vacation rentals feature amenities such as WiFi and washers and dryers so you'll have everything you need. If you're concerned about a clean environment, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great choice for families.