La Mesa Vacation Rentals

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Check prices for these dates

In two weeks
Jan 9 - Jan 11
In two months
Feb 20 - Feb 22
In three months
Mar 20 - Mar 22
In four months
Apr 17 - Apr 19

Our top choices for La Mesa vacation rentals

Fridge, microwave, oven, stovetop
Designer Poolside 1Bed1Bth Retreat

Vacation Home in La Mesa

Designer Poolside 1Bed1Bth Retreat
8.8 out of 10, Excellent, (6)
"Nice private property. Loved sitting by the pool. Very convenient to get around the area."
United States
Mary Jo F.
The price is ￥21,746
￥51,086 total
includes taxes & fees
Dec 25 - Dec 26
Designer Poolside 1Bed1Bth Retreat
Living area
Sunnyside Resort Spa, Beach, Zoo, Arcade

Villa in La Mesa

Sunnyside Resort Spa, Beach, Zoo, Arcade
2.0 star property
9.6 out of 10, Exceptional, (15)
"Beautiful location right in the middle of tons of fun places to get to in San Diego. Perfect home for a large group stay with backyard fun, great cooking area, and fun plentiful sleeping arrangements "
United States
Tyler K.
Sunnyside Resort Spa, Beach, Zoo, Arcade
Fridge, microwave, oven, stovetop
3 Bedroom House - Fire Pit Table, BBQ - 10 Guests

Vacation Home in La Mesa

3 Bedroom House - Fire Pit Table, BBQ - 10 Guests
9.0 out of 10, Wonderful, (14)
"We had a great time staying at the Fountain House. Everything was clean and comfortable. The neighborhood was quiet and located ideally for the various places we went while in La Mesa/SD area. The decor was very welcoming and up to date. We loved having our coffee in the front yard, which was refreshing with lots of shade. All details for our stay were clear, and all the things we needed were available (ice, glass ware, cooking utensils etc). We have zero complaints :) Thank you for hosting us."
United States
Chanel M.
3 Bedroom House - Fire Pit Table, BBQ - 10 Guests
Fridge, microwave, oven, stovetop
4BR/3Bth King Bed, Big Yard, Prime Area, Ranch

Vacation Home in La Mesa

4BR/3Bth King Bed, Big Yard, Prime Area, Ranch
2.0 star property
The price is ￥15,640
￥70,080 total
includes taxes & fees
Jan 11 - Jan 12, 2026
4BR/3Bth King Bed, Big Yard, Prime Area, Ranch
Fridge, oven, stovetop, coffee/tea maker
An elegant, fully furnished guest house for 2-4 guest in San Diego

Condo in Mount Helix

An elegant, fully furnished guest house for 2-4 guest in San Diego
9.0 out of 10, Wonderful, (2)
"We love a simple no-nonsense place and this was perfect for us. The host is very responsive and was constantly checking in with us on what else we need to be comfortable to stay here. The area is close a lot of nice restaurants so that was a plus. We would love to stay here next time we visit San Diego."
United States
Darakhshan T.
The price is ￥35,127
￥45,392 total
includes taxes & fees
Dec 26 - Dec 27
An elegant, fully furnished guest house for 2-4 guest in San Diego
Private kitchen
La Mesa New 3BR Oasis with Pool and Games!

Vacation Home in Mount Helix

La Mesa New 3BR Oasis with Pool and Games!
2.0 star property
The price is ￥18,110
￥72,440 total
includes taxes & fees
Jan 6 - Jan 7, 2026
La Mesa New 3BR Oasis with Pool and Games!
Microwave, oven, stovetop
Mediterranean-inspired 1BR Guesthouse - Full Kitchen, Workspace & Garden

Cottage in Mount Helix

Mediterranean-inspired 1BR Guesthouse - Full Kitchen, Workspace & Garden
2.0 star property
The price is ￥24,199
￥54,330 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Mediterranean-inspired 1BR Guesthouse - Full Kitchen, Workspace & Garden
Terrace/patio
Spacious 4BR/2BTH King Bed Ranch Style, Prime Area

Vacation Home in La Mesa

Spacious 4BR/2BTH King Bed Ranch Style, Prime Area
10.0 out of 10, Exceptional, (1)
The price is ￥16,897
￥65,029 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Spacious 4BR/2BTH King Bed Ranch Style, Prime Area
Beach nearby
Coronado Beach Resort

Condo in Historic Downtown Coronado

Coronado Beach Resort
3.0 star property
9.0 out of 10, Wonderful, (752)
"This stay was one of our best yet! Highly recommend! Friendly staff. Great space"
United States
Sheree
The price is ￥30,680
￥33,748 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Coronado Beach Resort
Deluxe Studio, 1 Queen Bed (Self Check-in with Virtual Front Desk) | Individually decorated, individually furnished, laptop workspace
Kasa Gaslamp Quarter San Diego

Aparthotel in Downtown San Diego

Kasa Gaslamp Quarter San Diego
3.5 star property
8.0 out of 10, Very Good, (154)
"Everything was perfect about the room and location. The minor flaw was the stench in the lobby from the downstairs restaurant and bar. I loved staying here. "
United States
Chris
Kasa Gaslamp Quarter San Diego
Premium bedding, pillowtop beds, desk, laptop workspace
Sentral Gaslamp Quarter

Aparthotel in Downtown San Diego

Sentral Gaslamp Quarter
4.0 star property
9.2 out of 10, Wonderful, (607)
"Everything was splendid. Very friendly staff as well. "
United States
Irving
The price is ￥17,118
￥24,373 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Sentral Gaslamp Quarter
Exterior
City24 Hotel Little Italy Mission Hills

Aparthotel in Middletown

City24 Hotel Little Italy Mission Hills
4.5 star property
9.6 out of 10, Exceptional, (107)
"would definitely go back and stay there again "
United States
Kounwick
City24 Hotel Little Italy Mission Hills
Outdoor pool, a heated pool
Wave Crest Resort

Condo in Del Mar

Wave Crest Resort
3.0 star property
9.2 out of 10, Wonderful, (144)
"Great location "
United States
Erin
The price is ￥32,048
￥41,506 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Wave Crest Resort
Fridge, microwave, oven, stovetop
'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!

Vacation Home in Encanto

'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!
2.0 star property
8.8 out of 10, Excellent, (30)
"The house was very clean and the neighborhood is pretty quiet. Great for vacation stay."
United States
AJ M.
The price is ￥12,490
￥35,276 total
includes taxes & fees
Dec 29 - Dec 30
'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!
Beach nearby
Tuluminati:BohoChic Condo Steps from Ocean and Bay

Condo in Mission Beach

Tuluminati:BohoChic Condo Steps from Ocean and Bay
10.0 out of 10, Exceptional, (4)
"Adorable, romantic room with lots of character and just a stone's throw from the beach! Comfy bed. Would stay here again."
United States
Alisha H.
Tuluminati:BohoChic Condo Steps from Ocean and Bay
Beach nearby
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Apartment in Mission Valley

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
9.2 out of 10, Wonderful, (56)
"Had a great time in San Diego. Will definitely stay there again!"
United States
Xavier Hicks H.
The price is ￥18,969
￥51,339 total
includes taxes & fees
Dec 30 - Dec 31
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Fridge, microwave, oven, stovetop
Spacious peacefull studio w/free parking, hot tub, gym. Near Balboa Park.

Apartment in Hillcrest

Spacious peacefull studio w/free parking, hot tub, gym. Near Balboa Park.
2.0 star property
10.0 out of 10, Exceptional, (1)
"Location, good building, lovely host."
United Kingdom
Clarice P.
The price is ￥10,616
￥26,534 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Spacious peacefull studio w/free parking, hot tub, gym. Near Balboa Park.
1 bedroom, iron/ironing board, free WiFi, bed sheets
Chic apartment with AC, pool and fitness room in sunny San Diego

Apartment in Downtown San Diego

Chic apartment with AC, pool and fitness room in sunny San Diego
10.0 out of 10, Exceptional, (2)
"Great stay!"
United States
Shay S.
The price is ￥25,418
￥32,522 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Chic apartment with AC, pool and fitness room in sunny San Diego
Property grounds
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Cottage in Old Town San Diego

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
10.0 out of 10, Exceptional, (268)
"We enjoyed our stay. The place was perfect and there was even a dog bed, toys, and a water dish filled with water waiting for us when we got there. Within walking distance to lots of dog friendly restaurants and within a 10-15min drive to all the things we wanted to do in San Diego, including an off leash dog beach. Would stay here again."
United States
Michele S.
The price is ￥29,663
￥37,661 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Outdoor pool
Kasa Little Italy San Diego

Aparthotel in Downtown San Diego

Kasa Little Italy San Diego
4.5 star property
9.6 out of 10, Exceptional, (355)
"Loved this place "
Canada
Ally
The price is ￥33,566
￥51,945 total
includes taxes & fees
Dec 29 - Dec 30
Kasa Little Italy San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top La Mesa Hotel Reviews

DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar

10/10 Excellent
"Courteous staff, clean room, quiet location"
Nita 2-night trip
Posted 1 day ago
DoubleTree by Hilton San Diego - Del Mar

Find out more about La Mesa

Search for holiday rentals in La Mesa on Expedia! You can easily find your home rentals, villas, holiday apartments in La Mesa using one of the methods below:

  • View our selection of featured holiday rentals in La Mesa
  • Use the map to find apartments and other holiday homes in the La Mesa neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in La Mesa while they last

Look no further and take a look at our great range of rental properties in La Mesa!

Frequently asked questions

Are there vacation rentals in La Mesa?

Yes, you can find vacation rentals in La Mesa near Computer Museum of America, or you can choose a secluded option if you'd like a relaxing place to stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

What are some of the best vacation rentals that La Mesa has to offer?

Oceanfront Beach, Pool, Hot Tub, Pickleball, Movie Theater, Elevator & Golf Cart: Visitors like this La Mesa vacation home rental. It is located on the beach and has an outdoor pool, a fireplace, and a barbecue grill to put you at ease in your new surroundings. It has 8 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. It offers a balcony, a garden, and a selection of games so you can immerse yourself in your vacation.

How many vacation rentals are there in La Mesa?

With 61 Expedia vacation rentals, you're sure to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

Explore the area and cultural attractions such as Computer Museum of America, or visit a family-friendly sight such as San Diego Zoo. While in the area, you can also visit popular places like Petco Park and Port of San Diego.

What are vacation rentals like in La Mesa?

Vacation rentals are privately owned properties you can book for several days or more in La Mesa. Vacation rentals feature amenities such as WiFi and washers and dryers so you'll have everything you need. If you're concerned about a clean environment, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great choice for families.