Photo by Michele Butts

La Mesa Vacation Rentals

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Jul 24 - Jul 25
Tomorrow
Jul 25 - Jul 26
This weekend
Jul 25 - Jul 27
Next weekend
Aug 1 - Aug 3

Vacation Rentals in La Mesa

Spacious 4-BR Home, King Bed, Ranch Style, La Mesa
Terrace/patio

Spacious 4-BR Home, King Bed, Ranch Style, La Mesa

The price is ￥14,762
￥54,755 total
includes taxes & fees
Jul 28 - Jul 29
Spacious 4-BR Home, King Bed, Ranch Style, La Mesa
Designer Poolside 1Bed1Bth Retreat
Fridge, microwave, oven, stovetop

Designer Poolside 1Bed1Bth Retreat

8.8 out of 10, Excellent, (6)
"Perfect spot in a beautiful neighborhood."
The price is ￥21,528
￥49,061 total
includes taxes & fees
Aug 19 - Aug 20
Designer Poolside 1Bed1Bth Retreat
3 Bedroom House - Fire Pit Table, BBQ - 10 Guests
Outdoor dining

3 Bedroom House - Fire Pit Table, BBQ - 10 Guests

9.4 out of 10, Exceptional, (13)
"We had a great time staying at the Fountain House. Everything was clean and comfortable. The neighborhood was quiet and located ideally for the various places we went while in La Mesa/SD area. The decor was very welcoming and up to date. We loved having our coffee in the front yard, which was refreshing with lots of shade. All details for our stay were clear, and all the things we needed were available (ice, glass ware, cooking utensils etc). We have zero complaints :) Thank you for hosting us."
3 Bedroom House - Fire Pit Table, BBQ - 10 Guests
Stunning Home & Spectacular View
Fridge, microwave, oven, stovetop

Stunning Home & Spectacular View

9.2 out of 10, Wonderful, (5)
"It was a beautiful spot and stay and everything was perfect and so much fun ."
The price is ￥56,090
￥122,432 total
includes taxes & fees
Aug 19 - Aug 20
Stunning Home & Spectacular View
SDSU/Downtown <10 Min - GameRoom - Fire Pit - Free Parking - Easy Freeway Access
Fridge, microwave, oven, stovetop

SDSU/Downtown <10 Min - GameRoom - Fire Pit - Free Parking - Easy Freeway Access

10.0 out of 10, Exceptional, (1)
"We stayed at this beautiful VRBO for our child’s college graduation in San Diego, and it couldn’t have been more perfect. The home was spotless, spacious, and exactly as described—if not better! Every room was thoughtfully appointed, and the beds were incredibly comfortable. The kitchen had everything we needed to cook family meals, and we loved gathering in the common areas to celebrate and relax.The location was ideal—close to the campus and shopping.Our host was responsive, welcoming, and...
The price is ￥46,278
￥82,451 total
includes taxes & fees
Jul 30 - Jul 31
SDSU/Downtown <10 Min - GameRoom - Fire Pit - Free Parking - Easy Freeway Access
Spacious 4-BR Home w King Bed, Big Yard in La Mesa
Fridge, microwave, oven, stovetop

Spacious 4-BR Home w King Bed, Big Yard in La Mesa

The price is ￥11,072
￥49,524 total
includes taxes & fees
Aug 3 - Aug 4
Spacious 4-BR Home w King Bed, Big Yard in La Mesa
Elegant House - Hot Tub Retreat On The Bridge
Smart TV, fireplace

Elegant House - Hot Tub Retreat On The Bridge

9.6 out of 10, Exceptional, (12)
"This cabin is gorgeous! The pictures don’t do it justice, truly. It was so comfy and the check-in process was super smooth. Would love to stay here again someday! "
The price is ￥60,560
￥131,668 total
includes taxes & fees
Jul 26 - Jul 27
Elegant House - Hot Tub Retreat On The Bridge
Mountain View, Jetted Tub, 2500 sqft, King Bed, Garage
Smart TV, books, music library

Mountain View, Jetted Tub, 2500 sqft, King Bed, Garage

The price is ￥22,143
￥52,209 total
includes taxes & fees
Jul 27 - Jul 28
Mountain View, Jetted Tub, 2500 sqft, King Bed, Garage
Luxury 2-Bedroom
Interior

Luxury 2-Bedroom

The price is ￥46,923
￥95,398 total
includes taxes & fees
Jul 29 - Jul 30
Luxury 2-Bedroom
Tranquil Private North San Diego Cottage/Guest 1 House
Outdoor pool

Tranquil Private North San Diego Cottage/Guest 1 House

9.0 out of 10, Wonderful, (33)
"The rules when you arrive are 3 pages long. The pool and hot tub are advertised as heated. They are not. You have to ask the owner and if it is convenient he will turn the heat on but it takes hours to warm up. The roof leaked when it rained and you cannot put anything on the kitchen counters for fear of staining. Would not stay again. Also no guests allowed. "
The price is ￥27,679
￥63,266 total
includes taxes & fees
Jul 29 - Jul 30
Tranquil Private North San Diego Cottage/Guest 1 House
Adorable 4 Bedroom Guest House wPool + Jacuzzi
Outdoor dining

Adorable 4 Bedroom Guest House wPool + Jacuzzi

10.0 out of 10, Exceptional, (11)
"Great place for hiking and running the trails of Poway"
The price is ￥54,919
￥94,461 total
includes taxes & fees
Jul 30 - Jul 31
Adorable 4 Bedroom Guest House wPool + Jacuzzi
La Casita Guest House, private fenced yard & with air conditioning, pet friendly
Fridge, microwave, oven, stovetop

La Casita Guest House, private fenced yard & with air conditioning, pet friendly

10.0 out of 10, Exceptional, (6)
"Property was clean and spacious for our extended visit to San Diego. "
The price is ￥21,235
￥50,853 total
includes taxes & fees
Aug 4 - Aug 5
La Casita Guest House, private fenced yard & with air conditioning, pet friendly
Near trolley. NEW charming 1-bedroom home in Fletcher hills, La Mesa.
Fridge, microwave, oven, stovetop

Near trolley. NEW charming 1-bedroom home in Fletcher hills, La Mesa.

10.0 out of 10, Exceptional, (10)
"This was such a great property! great neighborhood, not too far off the freeway, parking was great, the entire property was clean and welcoming. The rental exceeded my expectations and I will definitely be staying there again when I head down to SD."
The price is ￥21,821
￥40,032 total
includes taxes & fees
Jul 29 - Jul 30
Near trolley. NEW charming 1-bedroom home in Fletcher hills, La Mesa.
San Diego Home: AC, Hot Tub, Covered Patio & BBQ
Fridge, microwave, stovetop, dishwasher

San Diego Home: AC, Hot Tub, Covered Patio & BBQ

9.8 out of 10, Exceptional, (6)
"Enjoyed my weekend with the family lots of space, super clean, quiet neighborhood felt safe. I highly recommend you book your nights."
The price is ￥43,203
￥94,835 total
includes taxes & fees
Aug 4 - Aug 5
San Diego Home: AC, Hot Tub, Covered Patio & BBQ
Xlnc Exotic home Poway
Fridge, microwave, oven, stovetop

Xlnc Exotic home Poway

The price is ￥50,525
￥86,259 total
includes taxes & fees
Jul 28 - Jul 29
Xlnc Exotic home Poway
Pristine Poway Retreat
Fridge, microwave, oven, stovetop

Pristine Poway Retreat

2.0 star property
8.6 out of 10, Excellent, (7)
"Very nice and clean place. Great for family with kids. Would stay here again. "
The price is ￥37,052
￥77,179 total
includes taxes & fees
Aug 18 - Aug 19
Pristine Poway Retreat
Luxury Studio with Lake Views and Spacious Balcony
Terrace/patio

Luxury Studio with Lake Views and Spacious Balcony

2.0 star property
6.0 out of 10, (2)
"It was beautiful and very modern. We loved it and hope to come back again!! "
The price is ￥10,705
￥28,111 total
includes taxes & fees
Aug 3 - Aug 4
Luxury Studio with Lake Views and Spacious Balcony
Luxury 3-BR Home w Garage, Hot Tub, King Bed, Yard
Beach

Luxury 3-BR Home w Garage, Hot Tub, King Bed, Yard

The price is ￥34,416
￥66,928 total
includes taxes & fees
Aug 10 - Aug 11
Luxury 3-BR Home w Garage, Hot Tub, King Bed, Yard
Exotic home 3bed2bath 20min to beach downtown
Dining

Exotic home 3bed2bath 20min to beach downtown

2.0 star property
9.2 out of 10, Wonderful, (7)
"Wonderful stay, as advertised - thank you!"
The price is ￥31,633
￥57,701 total
includes taxes & fees
Aug 12 - Aug 13
Exotic home 3bed2bath 20min to beach downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesa Hotel Reviews

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

10/10 Excellent
"The stay was great continental breakfast was great just didn't like the fact that I didn't know that I had to pay nightly for parking after already booking the hotel stay. "
Sarah 2-night trip
Posted 10 hours ago
Hampton Inn San Diego/Mission Valley

Frequently asked questions

Are there vacation rentals in La Mesa?

Yes, you can find vacation rentals in La Mesa near Computer Museum of America, or you can choose a secluded option if you'd like a relaxing place to stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

What are some of the best vacation rentals that La Mesa has to offer?

OCEAN VIEWS! New Modern Style House-Great for Groups and Families: You might want to consider this vacation home rental near La Mesa, which is located near the beach and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals are there in La Mesa?

With 110 Expedia vacation rentals, you're sure to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

Explore the area and cultural attractions such as Computer Museum of America, or visit a family-friendly sight such as San Diego Zoo. While in the area, you can also visit popular places like Mission Bay and Petco Park.

What are vacation rentals like in La Mesa?

Vacation rentals are privately owned properties you can book for several days or more in La Mesa. Vacation rentals feature amenities such as WiFi and washers and dryers so you'll have everything you need. If you're concerned about a clean environment, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great choice for families.