South Main, TX
Houston
Visit South Main
Things to do
NASA's Space Center & Official Houston City Tour with tickets
Houston: Museum of Natural Science General Admission Ticket
Houston: Guided City Tour by an Open-Top Double Decker Bus
Houston's Official City & Mural Tour!
From Houston: Crocodile Encounter Entry Ticket
South Main Hotel Deals
Wyndham Houston at Reliant Park & Medical Center
"Restaurant and bar closed the whole time we stayed"
Reviewed on Sep 21, 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
"There was a bug in are bed bed"
Reviewed on Sep 22, 2026
Hotel Zaza Houston Museum District
"Love the location of the hotel. It was in the museum district, so you can walk to most of the museums. The area also has beautiful parks that are well maintained. The hotel decor was contemporary with touches of modern and nostalgic pictures. The staff was friendly, knowledgeable, and always happy ..."
Reviewed on Sep 21, 2026
The Whitehall Houston
"Great room! The hotel was beautiful, amazing bar and food! Loved the hospitality"
Reviewed on Sep 22, 2026
Club Quarters Hotel Downtown, Houston
Hyatt Regency Houston West
"Place was nice for the price. But when I got there already 2 hours past my check in time, they said the room still wasn’t ready because their cleaning staff hasn’t gotten to it yet. I had a concert to go to and needed to get ready so I asked if there was something we could check in to for the moment ..."
Reviewed on Sep 21, 2026
Where to stay in South Main
Downtown Houston
Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Daikin Park and Toyota Center are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
