A densely packed urban area with numerous buildings and a prominent tower on a hill.

Find hotels in Puerto Santa Ana, Guayaquil

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Sep 18 - Sep 20
Next weekend
Sep 25 - Sep 27

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Puerto Santa Ana hotels

Bar (on property)

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,005 reviews)
"Great hotel to stay in! Staff was super friendly!"
United States
Isabel
The price is ￥17,770
￥19,933 total
Sep 27 - Sep 28
Wyndham Guayaquil Puerto Santa Ana
Rooftop terrace

2. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (65 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ￥15,529
￥15,683 total
Sep 22 - Sep 23
River View suites Puerto Santa Ana gye
Lobby lounge

3. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (147 reviews)
"Great place historical. Good service n breakfast. Great location"
United States
Mary Grant
The price is ￥8,754
￥9,830 total
Oct 17 - Oct 18
Mansión del Río
Indoor pool

4. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (411 reviews)
"Love the area where the hotel is located. Excellent breakfast. The pool area is beautiful where you can seat and relax "
United States
Sixto
The price is ￥9,774
￥9,929 total
Sep 17 - Sep 18
Hotel Ramada
Food and drink

5. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (165 reviews)
"The pool was enjoyable but going during the day so the water isn’t as cold."
United States
Julio
The price is ￥6,874
￥7,029 total
Sep 17 - Sep 18
Hotel Patrimonial by Greenfield
Room

6. Hotel Las Peñas

Hotel Las Peñas
3.0 star property
Rocafuerte, 1.8 km from Puerto Santa Ana
8.4 out of 10, Very good, (123 reviews)
"Great location, kind staff, would recommend"
United States
Melida
The price is ￥3,665
￥3,819 total
Oct 11 - Oct 12
Hotel Las Peñas
Lobby

7. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (956 reviews)
"There’s a restaurant downstairs. Try the Encocado de camarón. Best food ever!"
United States
Marlaynna
The price is ￥10,040
￥11,277 total
Sep 20 - Sep 21
Hotel Palace Guayaquil
Children's activities

8. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,000 reviews)
"Very nice stay"
United States
Freddy
The price is ￥14,654
￥16,505 total
Sep 19 - Sep 20
Oro Verde Guayaquil
Bar (on property)

9. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Best hotel and great location food amazing"
United States
Giselle
The price is ￥12,340
￥13,805 total
Sep 27 - Sep 28
Wyndham Garden Guayaquil
Pool

10. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,003 reviews)
"This is my second stay at this property and again I am impressed. The food is good, the staff were helpful, and the room was comfortable. Great place"
United States
Tabitha
The price is ￥11,600
￥12,991 total
Oct 11 - Oct 12
Grand Hotel Guayaquil, Centro Histórico.
Restaurant

11. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (340 reviews)
"Clean, safe & secure facilities with friendly and accommodating staff. Rooms were decent size/layout, with very comfortable bedding, The food at the hotel is a little pricey but excellent, as is the location - steps away from other outstanding local restaurants."
United States
Carmen
The price is ￥9,718
￥10,921 total
Sep 25 - Sep 26
Ibis Styles El Malecon Guayaquil
Property entrance

12. DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 3 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (661 reviews)
"The hotel was very nice and a very helpful staff. Easy on the eyes too."
Canada
Jeff
The price is ￥5,553
￥5,707 total
Oct 9 - Oct 10
DC Suites Aeropuerto
Room

13. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ￥51,828
￥57,666 total
Sep 17 - Sep 18
Hotel Río Guayas by Art Hotels Ecuador
Comfort Double Room

14. Hotel GH Alexander

Hotel GH Alexander
3.5 star property
Rocafuerte, 2.1 km from Puerto Santa Ana
8.8 out of 10, Excellent, (47 reviews)
"Breakfast was amazing! I loved everything about it!"
United States
Josue
The price is ￥4,587
￥4,742 total
Sep 18 - Sep 19
Hotel GH Alexander
Suite, Jetted Tub

15. Hotel Varadero Internacional

Hotel Varadero Internacional
3.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
8.2 out of 10, Very good, (83 reviews)
"Overall a good place to stay and close to most destinations."
United States
Daniel
The price is ￥3,910
￥4,065 total
Sep 28 - Sep 29
Hotel Varadero Internacional
Front of property

16. Hotel Sada

Hotel Sada
3.0 star property
Roca, 1.5 km from Puerto Santa Ana
9.8 out of 10, Exceptional, (12 reviews)
"Habitación limpia, personal amable, y desayuno fresco. "
Mexico
Ligia
The price is ￥6,474
￥6,629 total
Oct 17 - Oct 18
Hotel Sada
Ecotours

17. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
7.6 out of 10, Good, (10 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ￥7,635
￥7,789 total
Sep 18 - Sep 19
Fortune Hotel
Breakfast meal

18. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,003 reviews)
"Excellent hotel"
United States
Monica
The price is ￥11,569
￥13,112 total
Sep 27 - Sep 28
Unipark by Oro Verde Hotels
Gym

19. Hotel Cityzen Guayaquil

Hotel Cityzen Guayaquil
3.0 star property
Roca, 1.6 km from Puerto Santa Ana
8.6 out of 10, Excellent, (46 reviews)
"Excelente for solo and young travelers."
United States
Fred
The price is ￥5,672
￥7,832 total
Sep 20 - Sep 21
Hotel Cityzen Guayaquil
Lobby

20. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,004 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ￥12,340
￥13,805 total
Sep 25 - Sep 26
Courtyard by Marriott Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Moorish Clock Tower while you're in town.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A green and yellow iguana on a rocky surface.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

A coastal cityscape at dusk with a prominent Ferris wheel, high-rise buildings, and a busy street.

Garzota

The restaurants and shopping are a few reasons travelers visit Garzota. Though there aren't many top sights in the neighborhood, you can visit Mall del Sol Shopping Center and City Mall, a few notable attractions nearby.

Top Puerto Santa Ana Hotel Reviews

Oro Verde Guayaquil

Oro Verde Guayaquil

10/10 Excellent
"Very modern property. Felt extremely safe staying here for 1 night between flights. Had a wonderful refreshing cocktail and dinner at the restaurant. Breakfast was excellent with a huge variety of dishes. Having a complimentary shuttle to and from the airport was a huge plus point, as didn’t need to negotiate or worry about the journey. The staff are very attentive and helpful."
Dhiraj 1-night trip
Posted 13 hours ago
Oro Verde Guayaquil

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 89 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.