A densely packed urban area with numerous buildings and a prominent tower on a hill.

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Check prices for these dates

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Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

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Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,001 reviews)
"Love staying at this hotel!"
United States
Isabel
The price is ￥14,952
￥16,839 total
Nov 22 - Nov 23
Wyndham Guayaquil Puerto Santa Ana
A rooftop pool with a view of the city skyline.

2. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (111 reviews)
"So clean and very nice people. I really recommend this facility, nice environment. My next trip lm booking in this apartment"
United States
Pedro
The price is ￥12,989
￥13,146 total
Nov 23 - Nov 24
Luxury Suites Riverfront GYE
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

3. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (66 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ￥12,272
￥13,996 total
Nov 3 - Nov 4
River View suites Puerto Santa Ana gye
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

4. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (151 reviews)
"The facility is very unique. Staff are very friendly. We have an early flight so did not get a chance to have breakfast."
United States
Shuyi
The price is ￥8,565
￥9,653 total
Nov 23 - Nov 24
Mansión del Río
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

5. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ￥54,090
￥61,273 total
Nov 3 - Nov 4
Hotel Río Guayas by Art Hotels Ecuador
A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

6. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,001 reviews)
"Todo excelente"
United States
Cristhian
The price is ￥11,708
￥13,114 total
Nov 8 - Nov 9
Wyndham Garden Guayaquil
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

7. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,004 reviews)
"Great location, delicious buffet and attentive staff."
United States
Edward
The price is ￥13,322
￥15,046 total
Nov 13 - Nov 14
Oro Verde Guayaquil
An outdoor cafe with tables and chairs, surrounded by trees and buildings.

8. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
7.6 out of 10, Good, (10 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ￥6,594
￥6,751 total
Nov 11 - Nov 12
Fortune Hotel
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

9. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (418 reviews)
"👍"
United States
Washington
The price is ￥9,874
￥10,031 total
Oct 25 - Oct 26
Hotel Ramada
A cocktail on a marble table with a pool in the background.

10. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (167 reviews)
"Excellent location and close to the airport."
United States
Martin Gerardo
The price is ￥6,329
￥6,486 total
Oct 24 - Oct 25
Hotel Patrimonial by Greenfield
A reception desk with a marble top and a modern light fixture above it.

11. TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"Great restaurant"
United States
Angela
The price is ￥13,322
￥15,046 total
Nov 1 - Nov 2
TRYP by Wyndham Guayaquil Airport
An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

12. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Great location, great breakfast buffet, adjacent to Iguana park, not far from airport."
Canada
Victor
The price is ￥12,006
￥13,444 total
Oct 25 - Oct 26
Grand Hotel Guayaquil, Centro Histórico.
A spacious indoor area with a central open space surrounded by seating arrangements and a pool.

13. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (752 reviews)
"Very helpful and accommodating airport shuttle service."
United States
Jerry
The price is ￥11,990
￥13,581 total
Oct 25 - Oct 26
Radisson Hotel Guayaquil
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

14. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,001 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ￥11,990
￥13,424 total
Oct 31 - Nov 1
Courtyard by Marriott Guayaquil
A modern interior with a seating area, a kitchen, and a dining space.

15. Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
3.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1,001 reviews)
"As close to the airport as you would want to be. No noise, and the pool and hot tube is great after a long travel time."
United States
Frederick
The price is ￥14,576
￥16,426 total
Nov 22 - Nov 23
Holiday Inn Guayaquil Airport by IHG
A high-rise hotel interior with multiple floors, large windows, and modern lighting fixtures.

16. Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 3.2 km from Puerto Santa Ana
8.8 out of 10, Excellent, (1,001 reviews)
"I made the reservation 30 minutes before my arrival through a 3rd party and everything went smoothly. Room was clean and The staff was very professional."
United States
Eduardo
The price is ￥15,320
￥17,244 total
Nov 22 - Nov 23
Hilton Colon Guayaquil
A breakfast table with various foods and a view of a park through a window.

17. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Great for a short stay"
United States
Maria
The price is ￥9,542
￥11,006 total
Nov 23 - Nov 24
Unipark by Oro Verde Hotels
A neatly made bed with a heart-shaped arrangement of red roses, a champagne bucket, and two wine glasses on a tray.

18. San Francisco Apart Hotel

San Francisco Apart Hotel
3.0 star property
La Atarazana, 1.4 km from Puerto Santa Ana
6.6 out of 10, (26 reviews)
"Nice place, nice amenities, nice staff, we'll back! "
United States
Giovanny
The price is ￥5,486
￥5,643 total
Oct 24 - Oct 25
San Francisco Apart Hotel
An outdoor dining area with wicker chairs and tables, a tiled floor, and a view of greenery through large windows.

19. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (354 reviews)
"Nice restaurant. Great location. Room was a good place to rest."
United States
Hector
The price is ￥9,874
￥11,096 total
Oct 30 - Oct 31
Ibis Styles El Malecon Guayaquil
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

20. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (963 reviews)
"We have stayed at this hotel several times and it is consistently a good experience. Comfortable bed, good air conditioning, restaurant on site, farmacia nearby. The breakfast buffet is especially good."
United States
Bethany
The price is ￥9,026
￥10,164 total
Nov 14 - Nov 15
Hotel Palace Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Puerto Santa Ana

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A modern bar area with a bar counter, seating, and a large window.
Wyndham Guayaquil Puerto Santa Ana
4.5 star property
9.4
Exceptional
1,001 reviews
View
A rooftop pool with a view of the city skyline.
Luxury Suites Riverfront GYE
3.5 star property
9.4
Exceptional
111 reviews
View
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.
River View suites Puerto Santa Ana gye
3.0 star property
9.0
Wonderful
66 reviews
View
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.
Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
10.0
Exceptional
5 reviews
View
A hotel with a modern facade, featuring a prominent vertical light installation.
Hotel Sada
3.0 star property
9.8
Exceptional
12 reviews
View

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Top Puerto Santa Ana Hotel Reviews

Oro Verde Guayaquil

Oro Verde Guayaquil

10/10 Excellent
"This is a very good hotel that I would highly recommend and I’m not a person that recommend something if it didn’t match up to its reviews and it certainly did that"
Debra 1-night trip
Posted less than an hour ago
Oro Verde Guayaquil

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 88 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.