A densely packed urban area with numerous buildings and a prominent tower on a hill.

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Oct 2 - Oct 4
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Oct 9 - Oct 11

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Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,009 reviews)
"Great hotel to stay in! Staff was super friendly!"
United States
Isabel
The price is ￥17,364
￥19,494 total
Oct 11 - Oct 12
Wyndham Guayaquil Puerto Santa Ana
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

2. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (65 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ￥16,844
￥17,001 total
Oct 4 - Oct 5
River View suites Puerto Santa Ana gye
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

3. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (147 reviews)
"Great place historical. Good service n breakfast. Great location"
United States
Mary Grant
The price is ￥9,342
￥10,433 total
Oct 4 - Oct 5
Mansión del Río
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

4. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ￥52,846
￥58,799 total
Sep 30 - Oct 1
Hotel Río Guayas by Art Hotels Ecuador
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

5. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (414 reviews)
"👍"
United States
Washington
The price is ￥9,917
￥10,074 total
Sep 30 - Oct 1
Hotel Ramada
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

6. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,004 reviews)
"Great Location!"
United States
Gustavo
The price is ￥14,627
￥16,483 total
Oct 4 - Oct 5
Oro Verde Guayaquil
An outdoor cafe with tables and chairs, surrounded by trees and buildings.

7. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
7.6 out of 10, Good, (10 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ￥7,785
￥7,942 total
Sep 30 - Oct 1
Fortune Hotel
A cocktail on a marble table with a pool in the background.

8. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (165 reviews)
"The pool was enjoyable but going during the day so the water isn’t as cold."
United States
Julio
The price is ￥6,975
￥7,132 total
Sep 30 - Oct 1
Hotel Patrimonial by Greenfield
An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

9. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,012 reviews)
"Nice breakfast setup the pool was fantastic and the room very spacious location was perfect next to everything"
United States
Edwin
The price is ￥11,334
￥12,703 total
Oct 30 - Oct 31
Grand Hotel Guayaquil, Centro Histórico.
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

10. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ￥12,582
￥14,076 total
Oct 3 - Oct 4
Courtyard by Marriott Guayaquil
A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

11. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,004 reviews)
"Best hotel and great location food amazing"
United States
Giselle
The price is ￥12,582
￥14,076 total
Oct 17 - Oct 18
Wyndham Garden Guayaquil
A reception desk with a marble top and a modern light fixture above it.

12. TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,005 reviews)
"Great staff and amazing breakfast!"
United States
William
The price is ￥14,218
￥16,033 total
Oct 17 - Oct 18
TRYP by Wyndham Guayaquil Airport
A high-rise hotel interior with multiple floors, large windows, and modern lighting fixtures.

13. Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 3.2 km from Puerto Santa Ana
8.8 out of 10, Excellent, (997 reviews)
"I like the location, amenities and staff is very helpful. Also, I felt very safe taking Ubers from the Hotel since is a chain of well known experienced drivers and very friendly"
United States
Marissa
The price is ￥15,917
￥17,902 total
Oct 24 - Oct 25
Hilton Colon Guayaquil
A buffet setup with various food items, a modern chandelier, and a patterned floor.

14. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (341 reviews)
"Clean, safe & secure facilities with friendly and accommodating staff. Rooms were decent size/layout, with very comfortable bedding, The food at the hotel is a little pricey but excellent, as is the location - steps away from other outstanding local restaurants."
United States
Carmen
The price is ￥9,909
￥11,136 total
Oct 2 - Oct 3
Ibis Styles El Malecon Guayaquil
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

15. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (957 reviews)
"There’s a restaurant downstairs. Try the Encocado de camarón. Best food ever!"
United States
Marlaynna
The price is ￥10,179
￥11,433 total
Oct 4 - Oct 5
Hotel Palace Guayaquil
A breakfast table with various foods and a view of a park through a window.

16. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,006 reviews)
"Clean hospitality excellent place to stay. Would come again ."
United States
silvia
The price is ￥12,425
￥14,061 total
Oct 4 - Oct 5
Unipark by Oro Verde Hotels
A neatly made bed with a heart-shaped arrangement of red roses, a champagne bucket, and two wine glasses on a tray.

17. San Francisco Apart Hotel

San Francisco Apart Hotel
3.0 star property
La Atarazana, 1.4 km from Puerto Santa Ana
6.4 out of 10, (25 reviews)
"Nice place, nice amenities, nice staff, we'll back! "
United States
Giovanny
The price is ￥5,509
￥5,666 total
Oct 4 - Oct 5
San Francisco Apart Hotel
A modern interior with a seating area, a kitchen, and a dining space.

18. Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
3.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1,008 reviews)
"Loved the closeness to Guayaquil airport, the staff was amazing, will definitely stay there again."
United States
Giovanna
The price is ￥15,728
￥17,694 total
Oct 4 - Oct 5
Holiday Inn Guayaquil Airport by IHG
A modern lobby with large windows, a staircase, and comfortable seating areas.

19. Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil
5.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (128 reviews)
"Good staff...great location"
United States
ALBERTO
The price is ￥12,031
￥15,382 total
Oct 11 - Oct 12
Doubletree By Hilton Guayaquil
A bedroom with a large bed, a desk, a chair, and a mural on the wall.

20. HOTEL PERLA CENTRAL MALECON

HOTEL PERLA CENTRAL MALECON
2.5 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
7.2 out of 10, Good, (30 reviews)
"Great location and friendly staff. We had a great stay."
Australia
Ashleigh
The price is ￥4,955
￥4,955 total
Oct 4 - Oct 5
HOTEL PERLA CENTRAL MALECON
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A densely packed hillside cityscape with colorful buildings and a prominent tower against a sunset sky.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Top Puerto Santa Ana Hotel Reviews

Oro Verde Guayaquil

Oro Verde Guayaquil

10/10 Excellent
"The neighborhood isn’t the best, but the hotel is really nice and comfortable. Breakfast has a lot of variety so it’s great. I travelled with a baby and they provided a crib."
Maria 2-night trip
Posted 19 hours ago
Oro Verde Guayaquil

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 89 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.