A densely packed urban area with numerous buildings and a prominent tower on a hill.

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Oct 16 - Oct 18
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Oct 23 - Oct 25

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Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,002 reviews)
"Excelente hotel"
United States
Juan
The price is ￥16,670
￥18,733 total
Nov 8 - Nov 9
Wyndham Guayaquil Puerto Santa Ana
A rooftop pool with a view of the city skyline.

2. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (111 reviews)
"So clean and very nice people. I really recommend this facility, nice environment. My next trip lm booking in this apartment"
United States
Pedro
The price is ￥11,115
￥11,274 total
Oct 28 - Oct 29
Luxury Suites Riverfront GYE
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

3. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (66 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ￥12,422
￥14,167 total
Nov 1 - Nov 2
River View suites Puerto Santa Ana gye
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

4. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (149 reviews)
"Great place historical. Good service n breakfast. Great location"
United States
Mary Grant
The price is ￥9,403
￥10,501 total
Oct 18 - Oct 19
Mansión del Río
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

5. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ￥49,639
￥55,276 total
Oct 14 - Oct 15
Hotel Río Guayas by Art Hotels Ecuador
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

6. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,005 reviews)
"Easy check in and staff very friendly"
United States
Michael
The price is ￥14,881
￥16,765 total
Oct 18 - Oct 19
Oro Verde Guayaquil
A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

7. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,005 reviews)
"Todo excelente"
United States
Cristhian
The price is ￥12,707
￥14,216 total
Nov 13 - Nov 14
Wyndham Garden Guayaquil
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

8. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,003 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ￥12,665
￥14,169 total
Oct 17 - Oct 18
Courtyard by Marriott Guayaquil
A cocktail on a marble table with a pool in the background.

9. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (166 reviews)
"The pool was enjoyable but going during the day so the water isn’t as cold."
United States
Julio
The price is ￥7,301
￥7,460 total
Oct 14 - Oct 15
Hotel Patrimonial by Greenfield
An outdoor cafe with tables and chairs, surrounded by trees and buildings.

10. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
7.6 out of 10, Good, (10 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ￥6,675
￥6,834 total
Oct 14 - Oct 15
Fortune Hotel
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

11. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (418 reviews)
"👍"
United States
Washington
The price is ￥9,994
￥10,153 total
Oct 15 - Oct 16
Hotel Ramada
An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

12. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,006 reviews)
"Great location, great breakfast buffet, adjacent to Iguana park, not far from airport."
Canada
Victor
The price is ￥11,905
￥13,332 total
Nov 2 - Nov 3
Grand Hotel Guayaquil, Centro Histórico.
A buffet setup with various food items, a modern chandelier, and a patterned floor.

13. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (348 reviews)
"Nice restaurant. Great location. Room was a good place to rest."
United States
Hector
The price is ￥9,974
￥11,209 total
Oct 23 - Oct 24
Ibis Styles El Malecon Guayaquil
A reception desk with a marble top and a modern light fixture above it.

14. TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,003 reviews)
"Great staff and amazing breakfast!"
United States
William
The price is ￥14,248
￥16,069 total
Nov 8 - Nov 9
TRYP by Wyndham Guayaquil Airport
A high-rise hotel interior with multiple floors, large windows, and modern lighting fixtures.

15. Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 3.2 km from Puerto Santa Ana
8.8 out of 10, Excellent, (1,001 reviews)
"I like the location, amenities and staff is very helpful. Also, I felt very safe taking Ubers from the Hotel since is a chain of well known experienced drivers and very friendly"
United States
Marissa
The price is ￥15,475
￥17,418 total
Nov 1 - Nov 2
Hilton Colon Guayaquil
A breakfast table with various foods and a view of a park through a window.

16. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,009 reviews)
"Clean hospitality excellent place to stay. Would come again ."
United States
silvia
The price is ￥9,775
￥11,149 total
Nov 1 - Nov 2
Unipark by Oro Verde Hotels
A modern interior with a seating area, a kitchen, and a dining space.

17. Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
3.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1,004 reviews)
"Loved the closeness to Guayaquil airport, the staff was amazing, will definitely stay there again."
United States
Giovanna
The price is ￥15,388
￥17,323 total
Nov 8 - Nov 9
Holiday Inn Guayaquil Airport by IHG
A room with a hammock, striped sofas, a stone floor, and a ceiling fan.

18. NCG SUITE ATARAZANA

NCG SUITE ATARAZANA
2.0 star property
La Atarazana, 0.8 km from Puerto Santa Ana
The price is ￥6,332
￥6,332 total
Oct 14 - Oct 15
NCG SUITE ATARAZANA
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

19. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (960 reviews)
"We have stayed at this hotel several times and it is consistently a good experience. Comfortable bed, good air conditioning, restaurant on site, farmacia nearby. The breakfast buffet is especially good."
United States
Bethany
The price is ￥9,252
￥10,415 total
Nov 13 - Nov 14
Hotel Palace Guayaquil
A buffet setup with pastries and various food items in jars.

20. Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel
5.0 star property
Simón Bolívar, 2.9 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (691 reviews)
"Breakfast lots of variety, service is good, free shuttle from airport"
Canada
Victoria
The price is ￥15,324
￥17,253 total
Oct 30 - Oct 31
Sheraton Guayaquil Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

A densely packed hillside cityscape with colorful buildings and a prominent tower against a sunset sky.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

Top Puerto Santa Ana Hotel Reviews

Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.

10/10 Excellent
"It was a pleasure staying here. My stay was better than expected."
Edward 5-night trip
Posted less than an hour ago
Grand Hotel Guayaquil, Centro Histórico.

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 88 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.