Top Puerto Santa Ana Hotels from ￥4,751

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Our top choices for Puerto Santa Ana hotels

A modern living room with a large window, a flat-screen TV, a sofa, and a coffee table.

1. Wyndham Guayaquil Puerto Santa Ana

Puerto Santa Ana

Isabel

￥18,867 total

Dec 6 - Dec 7

An indoor swimming pool with clear glass walls, a view of a cityscape, and a tiled deck area.

2. River View suites Puerto Santa Ana gye

Puerto Santa Ana

Aaliyah

￥14,262 total

Nov 16 - Nov 17

A modern hotel with a curved facade, multiple floors, and a glass exterior.

3. Luxury Suites Riverfront GYE

Puerto Santa Ana

Pedro

￥13,805 total

Nov 19 - Nov 20

A grand room with ornate chandeliers, a large mirror, and a staircase leading to another level.

4. Mansión del Río

Las Peñas, 0.6 km from Puerto Santa Ana

Shuyi

￥9,523 total

Nov 16 - Nov 17

A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

5. Hotel Río Guayas by Art Hotels Ecuador

Las Peñas, 0.6 km from Puerto Santa Ana

septimiu

￥39,221 total

Nov 30 - Dec 1

A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

6. Wyndham Garden Guayaquil

Simón Bolívar, 2.8 km from Puerto Santa Ana

Giselle

￥14,259 total

Dec 5 - Dec 6

An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

7. Hotel Ramada

Downtown Guayaquil, 1.3 km from Puerto Santa Ana

Pedro

￥10,222 total

Nov 15 - Nov 16

A breakfast table with various foods and a view of a park through a window.

8. Unipark by Oro Verde Hotels

Rocafuerte, 2 km from Puerto Santa Ana

Monica

￥11,832 total

Nov 20 - Nov 21

A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

9. Courtyard by Marriott Guayaquil

Kennedy, 2.5 km from Puerto Santa Ana

Richard

￥14,470 total

Nov 28 - Nov 29

A cocktail on a marble table with a pool in the background.

10. Hotel Patrimonial by Greenfield

Downtown Guayaquil, 1.4 km from Puerto Santa Ana

Jackson

￥7,510 total

Nov 15 - Nov 16

A spacious lobby with high ceilings, large windows, and modern furnishings.

11. Hilton Colon Guayaquil

Kennedy, 3.2 km from Puerto Santa Ana

Mayra

￥18,020 total

Nov 29 - Nov 30

A modern building with the Fortune Hotel sign, featuring a flat facade, large windows, and a gated entrance.

12. Fortune Hotel

River City, 1 km from Puerto Santa Ana

MARIA

￥7,117 total

Dec 15 - Dec 16

A modern interior with a seating area, a kitchen, and a dining space.

13. Holiday Inn Guayaquil Airport by IHG

3.7 km from Puerto Santa Ana

Iris

￥17,616 total

Dec 13 - Dec 14

An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

14. Grand Hotel Guayaquil, Centro Histórico.

Rocafuerte, 2.2 km from Puerto Santa Ana

Victor

￥13,607 total

Nov 22 - Nov 23

A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

15. Hotel Palace Guayaquil

Rocafuerte, 1.9 km from Puerto Santa Ana

Bethany

￥11,126 total

Nov 28 - Nov 29

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

16. TRYP by Wyndham Guayaquil Airport

Simón Bolívar, 2.8 km from Puerto Santa Ana

MIGUEL A.

￥17,143 total

Dec 6 - Dec 7

17. Ibis Styles El Malecon Guayaquil

Downtown Guayaquil, 1.7 km from Puerto Santa Ana

Hector

￥10,781 total

Nov 28 - Nov 29

A modern spa room with a hot tub, wooden steps, and a skylight.

18. Oro Verde Guayaquil

Downtown Guayaquil, 2.1 km from Puerto Santa Ana

ricardo

￥16,210 total

Dec 13 - Dec 14

A spacious indoor area with a central open space surrounded by seating arrangements and a pool.

19. Radisson Hotel Guayaquil

Kennedy, 2.9 km from Puerto Santa Ana

Jerry

￥13,855 total

Nov 15 - Nov 16

A modern hotel with a curved facade, large windows, and a prominent sign.

20. Hotel GH Galeria

Downtown Guayaquil, 2.1 km from Puerto Santa Ana

Sandra

￥13,431 total

Dec 15 - Dec 16

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Compare popular hotels in Puerto Santa Ana

Property	Star rating	Guest rating
Wyndham Guayaquil Puerto Santa Ana	4.5 star property	9.4 Exceptional 1,001 reviews	View
Luxury Suites Riverfront GYE	3.5 star property	9.4 Exceptional 112 reviews	View
River View suites Puerto Santa Ana gye	3.0 star property	9.0 Wonderful 67 reviews	View
Hotel Río Guayas by Art Hotels Ecuador	4.0 star property	10.0 Exceptional 6 reviews	View
Mansión del Río	3.5 star property	8.8 Excellent 152 reviews	View

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.

A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

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A colorful outdoor installation with large letters spelling out a word.

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

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Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

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A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

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Rosa Elvira

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Top Puerto Santa Ana Hotel Reviews

Wyndham Guayaquil Puerto Santa Ana

Puerto Santa Ana

10/10 Excellent

Sandra

Holiday Inn Guayaquil Airport by IHG

Guayaquil

10/10 Excellent

Eulalia

Unipark by Oro Verde Hotels

Downtown Guayaquil

10/10 Excellent

Jose

A courtyard with a fountain, seating area, and a building with a dome and clock tower.

Hotel del Parque

Samborondon

10/10 Excellent

This hotel is absolutely gorgeous! It’s a renovated hospice and every detail has been attended to. The showers were large and wonderful! The staff is courteous and friendly. Everything is very up to date and the entire property is very clean. The morning buffet is 5 star and so is the adjoining restaurant. Be sure to check out the beautiful chapel in the hotel! Also the hotel is right next door to a National Park with live animals. Definitely would stay again!

KRISTI

River View suites Puerto Santa Ana gye

Puerto Santa Ana

10/10 Excellent

KAREN

A hotel corridor with a tiled floor, a staircase with metal railings, and doors leading to rooms.

NCG Comegua 1

Guayaquil

10/10 Excellent

The apartment is exactly as pictured and described. The wifi worked well and the bedrooms had smart tvs so i was able to watch Netflix. Well stocked kitchen, warm shower and lots of security cameras. Heavy locked gates for added security. Beautiful terrace to look at the city. A couple things you should be aware of, 3rd floor no elevator but easy stairs and the shower floor is extremely slippery. Traffic noise in the morning but nothing crazy loud in my opinion. I slept well and had a great...

Michael Thomas

Wyndham Garden Guayaquil

Simón Bolívar

10/10 Excellent

Silvia

A rooftop pool area with lounge chairs, a bar, and a view of the city skyline.

Doubletree By Hilton Guayaquil

Downtown Guayaquil

10/10 Excellent

Pablo

Grand Hotel Guayaquil, Centro Histórico.

Downtown Guayaquil

10/10 Excellent

Grand Hotel is a stunning property. They took really good care of us, from airport pick-up to giving us milk for my toddler late at night. The receptionists were happy to help us with directions and answer any queries. The Grand Hotel pool is an oasis, it was breathtaking. We stayed here two nights. Breakfast spread was amazing and the food was delicious. We ate one dinner there too, totally worth it! Excellent service, great staff, breathtaking pool, decent-sized rooms, centrally located!

Niyati

Mansión del Río

Las Peñas

10/10 Excellent

John Thomas

Hotel Palace Guayaquil

Downtown Guayaquil

10/10 Excellent

It was one of my best choices the staff was very courteous always willing to make you feel comfortable. The room is spacious, comfortable and very clean. I slept like a baby. Definitely I would recommend The Palace hotel to anyone you won't regret it. I stayed two nights when I arrived and when I came back i booked the same hotel two more nights just to spend my last days in Guayaquil. One more thing The palace is located in the center of Guayaquil and the Malecon and the Park of the iguanas is...

Angela R.

Courtyard by Marriott Guayaquil

Kennedy

10/10 Excellent

This hotel has convenient, free, parking. It is clean and modern. The staff are all professional, friendly, and speak excellent english. The walls are a little thin but guests are pretty quiet. The pool on the 16th floor is open to the outside and wonderfully warm. The restaurant served an excellent buffet breakfast but dinner was so-so and pricey. I recommend finding dinner elsewhere. The hotel is less than 10 minutes from the airport in Guayaquil and has a free shuttle, which is very...

Robert

Frequently Asked Questions

What's it like in Puerto Santa Ana?

Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.

Where is the best hotel for a stay in Puerto Santa Ana?

Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.

How many hotels will I find in Puerto Santa Ana?

If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 88 Puerto Santa Ana hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.

Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?

To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.

What is there to do around this Guayaquil neighborhood?

Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.

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Find hotels in Puerto Santa Ana, Guayaquil from ￥4,751

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Treat yourself

Be picky

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Our top choices for Puerto Santa Ana hotels

1. Wyndham Guayaquil Puerto Santa Ana

2. River View suites Puerto Santa Ana gye

3. Luxury Suites Riverfront GYE

4. Mansión del Río

5. Hotel Río Guayas by Art Hotels Ecuador

6. Wyndham Garden Guayaquil

7. Hotel Ramada

8. Unipark by Oro Verde Hotels

9. Courtyard by Marriott Guayaquil

10. Hotel Patrimonial by Greenfield

11. Hilton Colon Guayaquil

12. Fortune Hotel

13. Holiday Inn Guayaquil Airport by IHG

14. Grand Hotel Guayaquil, Centro Histórico.

15. Hotel Palace Guayaquil

16. TRYP by Wyndham Guayaquil Airport

17. Ibis Styles El Malecon Guayaquil

18. Oro Verde Guayaquil

19. Radisson Hotel Guayaquil

20. Hotel GH Galeria

Compare popular hotels in Puerto Santa Ana

Where to stay in Puerto Santa Ana

Ecuador

Downtown Guayaquil

Kennedy

Simón Bolívar

Rosa Elvira

Top Puerto Santa Ana Hotel Reviews

Wyndham Guayaquil Puerto Santa Ana

10/10 Excellent

Frequently Asked Questions

What's it like in Puerto Santa Ana?

Where is the best hotel for a stay in Puerto Santa Ana?

How many hotels will I find in Puerto Santa Ana?

If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?

What is there to do around this Guayaquil neighborhood?

Explore a world of travel with Expedia