A rocky landscape with large boulders and a forested hill in the background.

De Soto Vacation Rentals

Q: What are some of the best vacation home rentals that De Soto has to offer?

Gated 35-Acre De Soto Estate: Pool, Lake & Patio! : Visitors like this De Soto vacation home rental. It offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games.

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Dates

November 2026

December 2026

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Our top choices for De Soto vacation rentals

A cozy living room with wooden walls, a large window, a television, and comfortable seating.

1. 82 Acre Hobby Farm with Lincoln Log Cabin

De Soto

DeAnn H.

￥41,254 total

includes taxes & fees

Nov 11 - Nov 12

A kitchen with white cabinets, a black refrigerator, and a wooden floor.

2. 2BR/1BA Pet-Friendly Escape Near Wineries & Hiking Trails

De Soto

Stephen L.

￥38,026 total

includes taxes & fees

Dec 7 - Dec 8

A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.

3. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

Jose

￥22,976 total

includes taxes & fees

Dec 9 - Dec 10

A cozy kitchen with two chairs, a small table with snacks, a coffee machine, and a view through a large window.

4. Vallee Suite at Baetje Farms

Bloomsdale

Heather

￥20,857 total

includes taxes & fees

Nov 11 - Nov 12

A room with two chairs, a table with a fruit platter, a hanging light fixture, and a view through a window with a curtain.

5. Amoureux Suite at Baetje Farms

Bloomsdale

￥20,857 total

includes taxes & fees

Nov 11 - Nov 12

A laundry room with two washers and a dryer, a checkered shelf above the dryers, a flower vase, and a sign that reads "Wash and Dry Laundry Service Co."

6. Clifford's Country Cottage

Bonne Terre

Philip

￥23,012 total

includes taxes & fees

Nov 11 - Nov 12

A wooden deck with two Adirondack chairs and a hammock.

7. Tiny Houses of French Village

French Village

Chris

￥53,760 total

includes taxes & fees

Nov 11 - Nov 12

A dining area with a dark wooden table, four chairs, and a central decorative item. A white refrigerator and a kitchen area with a stove and cabinets are visible in the background.

8. Upstairs 2 bedroom Private Apt Off I- 55 in Pevely

Pevely

Caren L.

￥35,552 total

includes taxes & fees

Nov 15 - Nov 16

9. Charming 2-bedroom house in nice Imperial with AC. Attn! Traveling Contractors

Imperial

Tommy H.

￥17,419 total

includes taxes & fees

Nov 11 - Nov 12

A cabin with a wooden staircase leading to a deck, surrounded by trees with autumn foliage.

10. Shady Pine Primitive Cabin 2 @Spring Lake Ranch

Potosi

Stephan

￥11,722 total

includes taxes & fees

Nov 15 - Nov 16

A living room with a fireplace, a sofa, a dining table with chairs, and a lamp.

11. Stay On Festus Main 2 bedroom 1.5 bath Near Mercy

Festus

Jennifer B.

￥37,764 total

includes taxes & fees

Nov 11 - Nov 12

A living room with a brown leather sofa, a wooden coffee table, a dining table with chairs, a ceiling fan, and a door with a wreath.

12. Cozy Serene home off 55 Queen Bed Smart TVs Wi-Fi

Pevely

James S.

￥37,290 total

includes taxes & fees

Nov 12 - Nov 13

A modern house with a covered porch, outdoor seating, and a pathway leading to the entrance.

13. Peaceful, cozy 1 bdrm home w hot tub & fire pit in the quiet countryside.

Bloomsdale

Blake H.

￥42,800 total

includes taxes & fees

Nov 18 - Nov 19

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

14. Tiny Houses of French Village Tranquil & Relaxing

French Village

James F.

￥54,191 total

includes taxes & fees

Nov 24 - Nov 25

A stone wall with a sign reading 'Peter Ray House' in front of a textured wall.

15. Peter Ray House

Maeystown

Eric

￥32,152 total

includes taxes & fees

Nov 11 - Nov 12

A wooden deck with a bed and a table, overlooking a forested area.

16. Tiny Houses of French Village Tranquil & Relaxing

French Village

Shannon S.

￥51,979 total

includes taxes & fees

Nov 16 - Nov 17

A fire pit surrounded by wooden chairs in an outdoor setting with string lights.

17. Beautiful historical two story stone farmhouse

Bonne Terre

Jeannine

￥65,269 total

includes taxes & fees

Nov 23 - Nov 24

A modern house with a stone facade, large windows, and a porch with two chairs.

18. Coeur de la Crème Suite at Baetje Farms

Bloomsdale

Eric C.

￥21,647 total

includes taxes & fees

Nov 11 - Nov 12

A hot tub with a view of a park and trees in the background.

19. Homestead Hideaway + Hot Tub

Fults

Janice G.

￥42,368 total

includes taxes & fees

Nov 15 - Nov 16

A bedroom with a large bed, white walls, wooden paneling, a dresser, bedside lamps, and a view of the outdoors.

20. Miette Suite at Baetje Farms

Bloomsdale

Christine M.

￥21,647 total

includes taxes & fees

Nov 11 - Nov 12

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Find vacation rentals that suit your style

Top De Soto Hotel Reviews

A modern kitchen with a central island, built-in appliances, and a view into the dining area.

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

10/10 Excellent

Anonymous traveler

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

Hampton Inn & Suites By Hilton Festus

Festus

10/10 Excellent

Misty

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

Drury Inn & Suites St. Louis Arnold

Arnold

10/10 Excellent

Rachel

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

10/10 Excellent

Dixon

A hotel lobby with a reception desk, two red armchairs, a floral centerpiece, a framed cityscape picture, and a dining area in the background.

Comfort Inn Festus - St Louis South

Festus

10/10 Excellent

CindyLucy

A modern interior with a high ceiling, large windows, and a brick wall. There are orange chairs and a green sofa with orange cushions.

Pear Tree Inn St. Louis Arnold

Arnold

10/10 Excellent

Blaine

A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

10/10 Excellent

Adrian

A large, two-story house with a wrap-around porch and a central tower.

The Conner House B&B

Prairie du Rocher

10/10 Excellent

Waited until the last minute to book a place to stay for an event in Redbud. Everything there was booked so had to expand our search and boy was that a blessing. Ended up at the Conner House and found a beautifully restored 1906 bed and breakfast. Very charming and inviting and took us back in time. Had a wonderful stay, learned a little history and had a great breakfast all thanks to our hostesses Pat & Connie. Forget the national chain - this is a must see house and getting to spend the...

Anonymous traveler

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

Crown Pointe Lodge, BW Signature Collection

Farmington

10/10 Excellent

Scott

A stone building with a white porch and a small garden with yellow flowers.

Corner George Inn Bed & Breakfast

Maeystown

10/10 Excellent

We stayed from 3/29 through 4/1. Unique place sitting directly next to a clear babbling brook. We stayed in The Loft room and it is very big, with a claw-foot tub and full kitchen that was stocked with dishes. The pillows and bed were devine. We slept completely through the night and woke feeling so refreshed. It was so quiet in the evenings that it was easy to picture yourself there in the 1890's with the world turning much slower around you. Many places were not open though since it was still...

Richard

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

10/10 Excellent

Rebecca

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

Super 8 by Wyndham Farmington

Farmington

10/10 Excellent

MarBella

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

Super 8 by Wyndham Potosi

Potosi

10/10 Excellent

Anonymous traveler

Find out more about De Soto

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Frequently Asked Questions

Can I find a vacation rental in De Soto?

Yes, there are vacation rentals close to the most popular attractions in De Soto, or you can choose a secluded option if you're looking for a relaxing stay. De Soto is known for its restaurants.

What are some of the best vacation home rentals that De Soto has to offer?

Gated 35-Acre De Soto Estate: Pool, Lake & Patio!: Visitors like this De Soto vacation home rental. It offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games.

What’s there to see and do in De Soto?

Sunrise Lake Beach and Big River are a couple of lovely local spots to get outside and enjoy nature. While here, Washington State Park and Big Lake are other places worth a visit.

What’s a vacation rental in De Soto like?

Vacation rentals are private properties you can stay in for several days or longer in De Soto. Vacation rentals offer amenities such as kitchens and laundry facilities so you'll have everything you want. If you're concerned about cleanliness, vacation rentals can offer a sense of seclusion away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular option for a family getaway.

De Soto Vacation Rentals

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for De Soto vacation rentals

1. 82 Acre Hobby Farm with Lincoln Log Cabin

2. 2BR/1BA Pet-Friendly Escape Near Wineries & Hiking Trails

3. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

4. Vallee Suite at Baetje Farms

5. Amoureux Suite at Baetje Farms

6. Clifford's Country Cottage

7. Tiny Houses of French Village

8. Upstairs 2 bedroom Private Apt Off I- 55 in Pevely

9. Charming 2-bedroom house in nice Imperial with AC. Attn! Traveling Contractors

10. Shady Pine Primitive Cabin 2 @Spring Lake Ranch

11. Stay On Festus Main 2 bedroom 1.5 bath Near Mercy

12. Cozy Serene home off 55 Queen Bed Smart TVs Wi-Fi

13. Peaceful, cozy 1 bdrm home w hot tub & fire pit in the quiet countryside.

14. Tiny Houses of French Village Tranquil & Relaxing

15. Peter Ray House

16. Tiny Houses of French Village Tranquil & Relaxing

17. Beautiful historical two story stone farmhouse

18. Coeur de la Crème Suite at Baetje Farms

19. Homestead Hideaway + Hot Tub

20. Miette Suite at Baetje Farms

Find vacation rentals that suit your style

Top De Soto Hotel Reviews

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

10/10 Excellent

Find out more about De Soto

Frequently Asked Questions

Can I find a vacation rental in De Soto?

What are some of the best vacation home rentals that De Soto has to offer?

What’s there to see and do in De Soto?

What’s a vacation rental in De Soto like?