Find Luxury Hotels in Central Missouri, MO

Plush bedding creates a peaceful sanctuary in each well-appointed room. Morning begins with a complimentary gourmet breakfast before guests retreat to the refreshing outdoor pool or maintain routines in the modern fitness center.

Sophisticated comfort awaits at this historic Columbia hotel where pristine accommodations feature premium bedding and designer toiletries. Savor exceptional dining at 3 restaurants, unwind in stylish bars, or explore downtown attractions just steps away. Attentive staff ensures every moment feels luxuriously refined.

Discover blissful indulgence at this waterfront oasis. The full-service Spa Shiki delivers aromatherapy, hydrotherapy, and couples treatments while two exceptional restaurants serve superb cuisine. Five bars, magnificent gardens with koi ponds, and pristine golf courses complete this rejuvenating sanctuary.

Sophisticated wellness awaits at this lakeside haven. Featuring a full-service spa with Swedish massages and hydrotherapy, 2 restaurants, and swim-up bar service, the resort pampers guests with pillowtop beds and private balconies overlooking scenic waters.

Restored splendor captivates guests at this historic downtown retreat. Luxurious pillowtop beds, an acclaimed restaurant serving exceptional cuisine, and charming ballroom create an atmosphere of refined comfort. Located minutes from Katy Trail with secure bicycle storage for adventurous travelers.

Vineyards, parks, and military heritage surround this intimate country inn. Spacious air-conditioned rooms provide refrigerators, microwaves, and luxury touches for an elevated stay. Minutes from Knob Noster State Park, this smoke-free sanctuary combines comfort with countryside serenity.

Pampered indulgence awaits at this newly renovated retreat. Sink into plush pillowtop beds with down comforters after enjoying the complimentary manager's reception. Morning brings a celebrated breakfast service with exceptional variety in immaculately maintained surroundings.

Spacious, air-conditioned accommodations welcome weary travelers with clean, comfortable beds and thoughtful workspace design. Located just 2 miles from Women's and Children's Hospital and Stephens Lake Park, this hotel balances peaceful seclusion with convenient access.