Brussels Vacation Rentals

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Check prices for these dates

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Dec 31 - Jan 1
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Jan 1 - Jan 2
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for Brussels vacation rentals

Fridge, microwave, oven, stovetop
McClusky Trail Guesthouse Convenient Access to Jerseyville, Grafton & Alton

Vacation Home in Jerseyville

McClusky Trail Guesthouse Convenient Access to Jerseyville, Grafton & Alton
10.0 out of 10, Exceptional, (21)
"Nicely appointed space, comfy beds, convenient location."
United States
Mike & JoAnn H.
The price is ￥16,608
￥33,513 total
includes taxes & fees
Jan 1 - Jan 2, 2026
McClusky Trail Guesthouse Convenient Access to Jerseyville, Grafton & Alton
Smart TV
Prime Loft of Main Street

Apartment in St. Charles Historic District

Prime Loft of Main Street
9.8 out of 10, Exceptional, (101)
"The loft was very nice, very clean, well appointed, and in a perfect location. I highly recommend this property!"
United States
Mary ann S.
The price is ￥15,341
￥34,975 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Prime Loft of Main Street
Fridge, microwave, oven, stovetop
Charming 2-bedroom townhome with a cozy fireplace in the heart of Grafton

Vacation Home in Grafton

Charming 2-bedroom townhome with a cozy fireplace in the heart of Grafton
9.8 out of 10, Exceptional, (9)
"Beautiful home.. rooms were clean... host was easy and readily available.. had issues with gate but host cleared up issues promptly. Overall we were very impressed and recommend for anyone staying in grafton area"
United States
William
Charming 2-bedroom townhome with a cozy fireplace in the heart of Grafton
Fridge, microwave, oven, stovetop
6th street 101 - Walk to Main St

Apartment in St. Charles Historic District

6th street 101 - Walk to Main St
10.0 out of 10, Exceptional, (1)
The price is ￥13,918
￥42,842 total
includes taxes & fees
Jan 4 - Jan 5, 2026
6th street 101 - Walk to Main St
TV
Riverside Home - Modern meets comfort

Vacation Home in Grafton

Riverside Home - Modern meets comfort
10.0 out of 10, Exceptional, (57)
"Wife and I both loved the outside seating in front and back. Very nice place to stay"
United States
David C.
The price is ￥16,889
￥48,228 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Riverside Home - Modern meets comfort
Smart TV, books, music library, computer monitors
Sunny SparkingClean King bed Apt- CreveCoeurPark

Apartment in Maryland Heights

Sunny SparkingClean King bed Apt- CreveCoeurPark
9.8 out of 10, Exceptional, (12)
"Good Stay"
United States
Lanai
The price is ￥17,001
￥37,121 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Sunny SparkingClean King bed Apt- CreveCoeurPark
Interior
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

Vacation Home in St. Charles Historic District

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
9.2 out of 10, Wonderful, (12)
"House was beautiful. Very nice quiet stay"
United States
Amy S.
The price is ￥13,918
￥37,760 total
includes taxes & fees
Jan 4 - Jan 5, 2026
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
Fridge, microwave, oven, stovetop
Amazing Renovated Historic Loft on Main Street

Apartment in St. Charles Historic District

Amazing Renovated Historic Loft on Main Street
10.0 out of 10, Exceptional, (57)
"Great place and location. Owners were easy to work with."
United States
Cory M.
The price is ￥16,748
￥37,357 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Amazing Renovated Historic Loft on Main Street
Dining
The Lofts of North Main Street

Apartment in St. Charles Historic District

The Lofts of North Main Street
9.6 out of 10, Exceptional, (156)
"Perfect location!"
United States
Tim K.
The price is ￥19,563
￥40,718 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Lofts of North Main Street
Fridge, microwave, oven, stovetop
Casa de Saint Charles

Vacation Home in Saint Charles

Casa de Saint Charles
9.2 out of 10, Wonderful, (17)
"We group of senior ladies thoroughly enjoyed our weekend at Casa de Saint Charles. The accommodations were perfect, inside and out. Our hosts were very accessible and made sure all our wants and needs were taken care of. What a wonderful home! "
United States
Rosalind W.
The price is ￥26,515
￥55,837 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Casa de Saint Charles
2 bedrooms, desk, iron/ironing board, travel crib
Madison House 1 -Walk to Main St

Vacation Home in St. Charles Historic District

Madison House 1 -Walk to Main St
8.6 out of 10, Excellent, (16)
"The house was clean and well stocked, location was great, and plenty of street parking. "
United States
Brad K.
The price is ￥13,918
￥37,760 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Madison House 1 -Walk to Main St
Private kitchen
Quaint and Cozy Hamlet

Vacation Home in O'Fallon

Quaint and Cozy Hamlet
9.4 out of 10, Exceptional, (13)
"Overall great time- communication was wonderful with Kevin, neighborhood was quiet, perfect for our stay. The house wasn’t as clean as I’d expect but besides that, great stay!"
United States
Madison A.
The price is ￥15,794
￥54,395 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Quaint and Cozy Hamlet
Fridge, microwave, oven, stovetop
Main Street Living! 2 Bedroom Unit right On Main!

Apartment in St. Charles Historic District

Main Street Living! 2 Bedroom Unit right On Main!
9.6 out of 10, Exceptional, (34)
"Great Stay and great location! "
United States
Angela
The price is ￥25,334
￥62,595 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Main Street Living! 2 Bedroom Unit right On Main!
Fridge, microwave, oven, stovetop
2 Bed Townhome w/ Backyard and Laundry by StayLage

Vacation Home in Saint Charles

2 Bed Townhome w/ Backyard and Laundry by StayLage
8.8 out of 10, Excellent, (17)
"Wish we would have had more time to stay a little longer. Will definitely stay again in the future!"
United States
Rebecca O.
The price is ￥17,733
￥48,152 total
includes taxes & fees
Jan 12 - Jan 13, 2026
2 Bed Townhome w/ Backyard and Laundry by StayLage
Fridge, microwave, oven, stovetop
Saint Charles 2 Bedroom Townhome by StayLage

Vacation Home in Saint Charles

Saint Charles 2 Bedroom Townhome by StayLage
9.2 out of 10, Wonderful, (7)
"We were very happy with our experience. Everything was as advertised, all of the basics were covered for us. Great place to stay. Thanks"
United States
bill r.
The price is ￥18,578
￥49,752 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Saint Charles 2 Bedroom Townhome by StayLage
Fridge, microwave, oven, stovetop
The Lewis & Clark Hangout

Vacation Home in St. Charles Historic District

The Lewis & Clark Hangout
8.8 out of 10, Excellent, (20)
"Excellent location and a great space for 4 couples. The beds were exceptionally comfortable! "
United States
Kimberly C.
The price is ￥24,864
￥60,472 total
includes taxes & fees
Jan 25 - Jan 26, 2026
The Lewis & Clark Hangout
Fridge, oven, stovetop, coffee/tea maker
Spacious 2 Bedroom Townhome by StayLage

Vacation Home in Saint Charles

Spacious 2 Bedroom Townhome by StayLage
8.8 out of 10, Excellent, (9)
"Perfect size"
United States
Barbie D.
The price is ￥18,578
￥49,752 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Spacious 2 Bedroom Townhome by StayLage
Private kitchen
1st Capitol Mansion - Suite 401

Vacation Home in St. Charles Historic District

1st Capitol Mansion - Suite 401
7.6 out of 10, Good, (8)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
The price is ￥13,881
￥36,724 total
includes taxes & fees
Jan 1 - Jan 2, 2026
1st Capitol Mansion - Suite 401
Outdoor dining
Rafton Inn Vacation Cottage 93

Apartment in Grafton

Rafton Inn Vacation Cottage 93
9.6 out of 10, Exceptional, (5)
"Great place & location. Very clean & accommodating."
United States
Mike F.
The price is ￥23,396
￥51,243 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Rafton Inn Vacation Cottage 93
Fridge, microwave, oven, stovetop
The Hidden Gem - 2BR Basement Apartment on 7 Acres

Apartment in Moscow Mills

The Hidden Gem - 2BR Basement Apartment on 7 Acres
10.0 out of 10, Exceptional, (12)
"Great place, nice neighborhood. "
United States
Julie L.
The price is ￥17,202
￥38,939 total
includes taxes & fees
Jan 5 - Jan 6, 2026
The Hidden Gem - 2BR Basement Apartment on 7 Acres
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Brussels Hotel Reviews

Hilton St. Louis Airport

Hilton St. Louis Airport

10/10 Excellent
"All"
LORETTA Sternes 7-night trip
Posted 3 days ago
Hilton St. Louis Airport

Find out more about Brussels

Search for holiday rentals in Brussels on Expedia! You can easily find your home rentals, villas, holiday apartments in Brussels using one of the methods below:

  • View our selection of featured holiday rentals in Brussels
  • Use the map to find apartments and other holiday homes in the Brussels neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Brussels while they last

Look no further and take a look at our great range of rental properties in Brussels!

Frequently asked questions

Are there vacation rentals in Brussels?

Yes, we have vacation rentals close to popular points of interest in Brussels, or you can choose a more remote option if you want a relaxing place to stay.

What are some of the best vacation rentals in Brussels?

The St. Charles Guest House, lovely historic home, fun for families and groups: This vacation home rental outside of Brussels is located on a river and has a fireplace, a selection of games, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What can I see and do in Brussels?

While exploring the area, visit family-friendly sights like Raging Rivers Waterpark, or get outside and enjoy nature at Mississippi River. Pere Marquette State Park and CarShield Field are a couple of places you'll find in the larger area.

What are vacation rentals like in Brussels?

A vacation rental is a private property you can book for a couple of days or more in Brussels. Vacation rentals provide amenities like WiFi and washers and dryers so you'll feel just like you're staying in your own home. If you're concerned about a clean environment, vacation rentals can offer a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you to travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive choice for a family trip or a small group gathering.