The Best Resorts & Hotels with Spas in Appalachian Plateau from ￥9,607 in 2026

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Our top choices for Appalachian Plateau hotels with a spa

An outdoor patio with stone walls, a fire pit, and orange chairs.

1. Hampton Inn & Suites Parkersburg Downtown

Parkersburg

Rejuvenate at this downtown hotel featuring a full-service spa, indoor pool, and tranquil spaces for a restorative escape.

￥25,704 total

includes taxes & fees

Nov 22 - Nov 23

A salon interior with a reception desk, two chairs, a white chair, shelves with products, and a large window.

2. The Blennerhassett Giovanni Hotel, Trademark Col. by Wyndham

Parkersburg

Rejuvenate at this historic hotel where classic charm meets modern spa indulgence in the heart of town.

￥22,263 total

includes taxes & fees

Nov 23 - Nov 24

A spacious lobby with a central round table, seating area, and a reception desk.

3. Holiday Inn Express & Suites Zanesville North by IHG

Zanesville

Discover a serene wellness retreat with a rejuvenating full-service spa and pristine indoor pool at this newly renovated hotel.

￥19,252 total

includes taxes & fees

Dec 4 - Dec 5

A multi-story hotel with a snow-covered ground, large windows, and balconies.

4. Carlisle Inn Sugarcreek

Sugarcreek

Serene countryside retreat offers balcony views, rejuvenating spa services, and indoor pool for total relaxation.

￥21,430 total

includes taxes & fees

Dec 6 - Dec 7

A modern lounge area with a stone fireplace, comfortable seating, a flat-screen TV, and a decorative vase.

5. Comfort Inn & Suites Caldwell

Caldwell

￥14,031 total

includes taxes & fees

Dec 7 - Dec 8

A well-lit entrance with a modern architectural design, featuring a central pavilion and a landscaped area with a water feature.

6. Oglebay Resort

Oglebay Park

Discover a tranquil resort with a full-service spa, indoor pool, and scenic golf courses nestled within a regional park setting.

￥24,496 total

includes taxes & fees

Dec 6 - Dec 7

A white building with a porch, a sign for The Inn on Negley, and a brick staircase leading up to the entrance.

7. The Inn on Negley

Shadyside

Unwind at this Victorian inn with serene garden views and Swedish massages for a peaceful retreat in the heart of Pittsburgh.

￥57,309 total

includes taxes & fees

Nov 11 - Nov 12

A spacious lobby with a central fountain, seating areas, and signs for LBV Steakhouse and Pasta.

8. Mountaineer Casino Resort

New Cumberland

Rejuvenate at this casino resort's full-service spa with daily body treatments, wraps, and massages alongside indoor and outdoor pools.

￥22,743 total

includes taxes & fees

Nov 9 - Nov 10

9. Avenwood Cabins

New Straitsville

￥29,059 total

includes taxes & fees

Dec 3 - Dec 4

A hotel room with two beds, a nightstand, a lamp, a phone, and a sunset mural on the wall.

10. Days Inn by Wyndham Jellico - Tennessee State Line

Jellico

Relax amid mountain state park scenery at this retreat, featuring a full-service spa and deep soaking tubs for complete rejuvenation.

￥10,976 total

includes taxes & fees

Nov 11 - Nov 12

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Choose what matters most at spa hotels in Appalachian Plateau

Pool

Breakfast included

Top Appalachian Plateau Hotel Reviews

The Inn on Negley

Shadyside

10/10 Excellent

Kira

A multi-story hotel with a porch area, outdoor seating, and a clock.

Carlisle Inn Walnut Creek

Millersburg

10/10 Excellent

Jeff

Carlisle Inn Sugarcreek

Sugarcreek

10/10 Excellent

Jackie

The Blennerhassett Giovanni Hotel, Trademark Col. by Wyndham

Parkersburg

10/10 Excellent

Robert

The Sunrise Cabin-Hot Tub, Pond, Fire Pit Near Red River Gorge

Beattyville

10/10 Excellent

Christina

A bathroom with a large bathtub, a sink, and a mirror.

Asbury Inn & Suites

Wilmore

10/10 Excellent

James

Comfort Inn & Suites Caldwell

Caldwell

10/10 Excellent

J.R.

A couple in a modern bathroom with a mosaic wall, a bathtub, and a large window.

Seneca Allegany Resort & Casino

Salamanca

10/10 Excellent

Katie

A massage therapy session on a wooden deck overlooking a lake, with a fountain in the background.

Cherry Ridge Retreat

New Plymouth

10/10 Excellent

Upon arrival we were so blown away by the beauty of the cabin we decided to inquire and book an extra night as 2 nights just would not be enough time. We spent our first night soaking in each other and soaking in the hot tub. Day 2 we visited the sauna pods and booked a professional photography session which lead to a proposal! Then we enjoyed a unique romantic dinner at Glenlaurel (it’s a must try). Our last day was filled with hiking, visiting the Hocking hills winery, deer watching, sitting...

Jacqueline

A covered outdoor area with a wooden structure, stone walls, and seating arrangements.

Stonewall Resort

Roanoke

10/10 Excellent

mark

Oglebay Resort

Oglebay Park

10/10 Excellent

I’m originally from the area, but moved away when I went to college. We try to come back at least once a year to visit family still in the area. We ALWAYS visit Oglebay Park, but this was my first time staying at Wilson Lodge. I loved it! Oglebay has grown significantly since I was little with various activities for kids to enjoy. The indoor pool was great. My son enjoyed it and the game room. My favorite of it all is just enjoying nature, the landscape, and the fresh air. Whenever we’re back in...

Lisa

A modern interior with a checkered floor, a glass ceiling, and a staircase leading to a window.

Bertram Inn at Glenmoor

Canton

10/10 Excellent

Kenneth

A historic hotel with a signboard detailing its history and amenities.

Armour's Hotel

Red Boiling Springs

10/10 Excellent

What a special place! Such a relaxing and enjoyable experience soaking in the springs and relaxing on the healing mats. The only downsides are the rooms are smaller and bathroom situation for larger people is a hazard for hitting your head or bumping into things. That's the charm though as it's a true historic building and it is part of the experience. The area is so beautiful and quaint, highly recommend a trip to explore this historic region with the beautiful foliage and the homemade fresh...

Amanda

Find out more about Appalachian Plateau

Top Appalachian Plateau attractions for a relaxing vacation

Travelers seeking a rejuvenating getaway in the Appalachian Plateau will find a wealth of activities and serene spa hotels to indulge in. Begin your adventure at the breathtaking Cuyahoga Valley National Park, where you can hike scenic trails, discover stunning waterfalls, and unwind with a tranquil picnic surrounded by nature. For a taste of local culture, visit the charming town of Asheville, known for its vibrant arts scene and historic architecture, where you can explore local galleries and enjoy farm-to-table dining experiences. Don't miss a visit to the hot springs in the area, such as those found in Hot Springs, North Carolina, where you can soak in natural mineral waters while enjoying the peaceful mountain views. Additionally, the Blue Ridge Parkway offers picturesque drives and overlooks, perfect for a leisurely day spent taking in the stunning landscapes. To enhance your experience, consider staying in luxury spa resorts nestled within these beautiful surroundings, where you can enjoy personalized treatments, fine dining, and easy access to outdoor adventures, ensuring a perfect blend of relaxation and exploration.

Find Resorts & Hotels with Spas in Appalachian Plateau

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Appalachian Plateau hotels with a spa

1. Hampton Inn & Suites Parkersburg Downtown

2. The Blennerhassett Giovanni Hotel, Trademark Col. by Wyndham

3. Holiday Inn Express & Suites Zanesville North by IHG

4. Carlisle Inn Sugarcreek

5. Comfort Inn & Suites Caldwell

6. Oglebay Resort

7. The Inn on Negley

8. Mountaineer Casino Resort

9. Avenwood Cabins

10. Days Inn by Wyndham Jellico - Tennessee State Line

Choose what matters most at spa hotels in Appalachian Plateau

Top Appalachian Plateau Hotel Reviews

The Inn on Negley

10/10 Excellent

Find out more about Appalachian Plateau

Top Appalachian Plateau attractions for a relaxing vacation