10 minute walk from the Grand Canal, the Olivetti museum, St Mark's Tower, The Doges Palace and literally next door to Teatro La Fenice. 20 minutes from the Guggenheim via the wooden Accademia bridge. So, since you're so close to the Grand Canal, easy to get to Murano and to and from the airport whether you take the boat (or the bus to Piazzale Roma then a boat...)
The staff are absolutely great: rooms perfectly clean, exceptionally helpful reception staff, breakfast waitresses absolutely marvellous sorting me out gluten free food. (A basket of individually wrapped gluten free baked goods and cereals stored away from the main buffet breakfast and coeliacs know how important that is)
If you're in the restaurant or in certain rooms, one side faces on to the canal so expect a serenade from gondoliers. Lots of quirky architectural details around the building and lifts to the higher floors.
I need to make plans to go back...