The Best Hotels Closest to St. Louis Science Center in St. Louis for 2026

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Our top choices for St. Louis Science Center hotels

1. Drury Inn & Suites St. Louis Forest Park

2 km from St. Louis Science Center

Tammy

￥24,860 total

includes taxes & fees

Nov 1 - Nov 2

An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

2. Hampton Inn & Suites St. Louis at Forest Park

Dogtown, 1 km from St. Louis Science Center

Greg

￥24,215 total

includes taxes & fees

Nov 23 - Nov 24

A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

3. The Royal Sonesta Chase Park Plaza St. Louis

Central West End, 1.8 km from St. Louis Science Center

Sara

￥29,531 total

includes taxes & fees

Nov 22 - Nov 23

A modern living room with a fireplace, sofas, a coffee table, and a bookshelf.

4. AC Hotel St. Louis Central West End

Central West End, 1.8 km from St. Louis Science Center

Janice

￥26,763 total

includes taxes & fees

Nov 20 - Nov 21

An outdoor dining area with multiple wooden tables and benches, surrounded by wicker chairs.

5. Hotel Indigo St Louis - Central West End by IHG

Central West End, 1.7 km from St. Louis Science Center

Lydia

￥24,944 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor patio area with seating, planters, and a grill.

6. Element by Marriott St. Louis Midtown

Midtown, 2.7 km from St. Louis Science Center

Julie

￥24,308 total

includes taxes & fees

Nov 15 - Nov 16

A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.

7. The West End

Central West End, 2.3 km from St. Louis Science Center

Trevor

￥19,729 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.

8. Home2 Suites by Hilton St. Louis/Forest Park

The Grove, 0.9 km from St. Louis Science Center

Molly

￥28,632 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor dining area with a glass table and chairs, a neon sign, and a city view.

9. Aloft by Marriott St Louis Central West End

Central West End, 1.8 km from St. Louis Science Center

Brittany

￥20,974 total

includes taxes & fees

Nov 2 - Nov 3

A modern hotel room with a large bed, a desk with a chair, a blue armchair, a sofa, a TV, and a large window offering a city view.

10. DoubleTree by Hilton St. Louis Forest Park

Central West End, 1.3 km from St. Louis Science Center

Loleta

￥27,621 total

includes taxes & fees

Nov 15 - Nov 16

A spacious foyer with a grand staircase, a piano, and a large rug.

11. White House at Grand Central

3 km from St. Louis Science Center

Priscilla

￥19,522 total

includes taxes & fees

Nov 1 - Nov 2

A bedroom with a large bed, a mirror, and a vanity with shelves.

12. Central West End B&B

Central West End, 3 km from St. Louis Science Center

Stacee

￥30,497 total

includes taxes & fees

Oct 29 - Oct 30

A hotel room with two beds, a chair, a desk, and a large window.

13. Forest Park Hotel by MDR

The Hill, 1.8 km from St. Louis Science Center

Kevan

￥14,136 total

includes taxes & fees

Nov 26 - Nov 27

A hotel room with a large bed, a desk, a chair, a television, and a microwave.

14. Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave

The Hill, 1.8 km from St. Louis Science Center

Sean

￥13,818 total

includes taxes & fees

Nov 1 - Nov 2

A well-lit lobby with a chandelier, potted plants, and a seating area.

15. Truitt Hotel

Lafayette Square, 4.9 km from St. Louis Science Center

Gabrielle

￥32,118 total

includes taxes & fees

Nov 1 - Nov 2

A rooftop terrace with wicker furniture, offering a city view.

16. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis, 7.1 km from St. Louis Science Center

Blake

￥26,517 total

includes taxes & fees

Nov 1 - Nov 2

A restaurant with round tables and chairs, a bar area, and a patterned ceiling.

17. Drury Plaza Hotel St. Louis Brentwood

6.5 km from St. Louis Science Center

Stacey Rochelle

￥23,940 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

18. Pear Tree Inn St. Louis Airport

15 km from St. Louis Science Center

Curtiss

￥16,828 total

includes taxes & fees

Nov 1 - Nov 2

A hallway with framed artwork on the walls and a poster advertising an event.

19. Benton Park Inn

Benton Park, 5.5 km from St. Louis Science Center

Lindsay

￥25,792 total

includes taxes & fees

Nov 3 - Nov 4

A bedroom with a large bed, a sitting area with a chair, a vanity with a mirror, and a bathtub.

20. The Lodge at Grant's Trail

10.1 km from St. Louis Science Center

Sherri

￥32,106 total

includes taxes & fees

Nov 1 - Nov 2

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Compare popular hotels close to St. Louis Science Center

Property	Star rating	Guest rating
Drury Inn & Suites St. Louis Forest Park	3.0 star property	9.4 Exceptional 1,031 reviews	View
Hampton Inn & Suites St. Louis at Forest Park	3.5 star property	9.4 Exceptional 1,000 reviews	View
The Royal Sonesta Chase Park Plaza St. Louis	4.5 star property	9.2 Wonderful 1,012 reviews	View
AC Hotel St. Louis Central West End	4.0 star property	9.0 Wonderful 860 reviews	View
Hotel Indigo St Louis - Central West End by IHG	3.5 star property	8.8 Excellent 1,004 reviews	View

Top St. Louis Science Center Hotel Reviews

Home2 Suites by Hilton St. Louis/Forest Park

10/10 Excellent

"Very helpful staff, free parking, breakfast included. Great location for the zoo or city museum."

Hotel Indigo St Louis - Central West End by IHG

8/10 Good

"Hotel is great condition. Room clean and modern. Excellent customer service from Dan.. No other staff actually spoke to me. Just the hallway smells like smoke. And I attempted to purchase breakfast from the crepes place but decided not to. The cook wiped his nose and didn’t attempt to wash hands before placing on gloves.."

Cozy townhouse in the heart of "The Grove". Minutes from Forest Park and Zoo.

10/10 Excellent

"A wonderful place to stay if you want easy access to Forest park, the zoo and even a quick drive downtown. An old brick townhome that has been remodeled but still has old-school charm and imperfections. It was nice to have coffee supplies (filters, powdered creamer, sweeteners) - just bring your favorite grounds. Lots of small local restaurants within walking distance and a coffee shop 10 steps from the front door. We went to the zoo, an escape room, did some shopping. The drive to everything from this location was quick. The host was quick to respond when needed. NOTE ON FIRST WEEK OF OCTOBER: We were there Oct. 2-4 while Oktoberfest at Urban Chestnut Brewing was going on right in front of the house. The whole street was blocked off for the party. GREAT location if you want to attend that weekend event. However, don't book the first week of October if you want a quiet retreat. It was a nice surprise for us, and we enjoyed it."

Cielo Casa on “The Hill” - Hot Tub + Spacious 3BR - Near BJC, SLU & Downtown

10/10 Excellent

"We loved our stay! This home had everything we needed, including a private fenced-in yard. The location was perfect—within walking distance of The Hill and just a quick drive to the Arch and Forest Park. The home was comfortable, convenient, and in a great location. We would definitely stay here again!"

4BR Near Forest Park Zoo & Missouri Botanical Garden | Free Parking | STL

10/10 Excellent

"We had a wonderful time. We were here for a wedding at the Wild Carrot and a pre wedding picnic at Tower Grove park so the location is perfect. We walked to the Science Center. Beds were comfortable and plentiful. I loved having plenty of towels available for all of us. The kitchen had all the dishes, etc that we needed. Everything was clean and inviting. If we are ever back in St. Louis, we certainly would choose this house again. Thank you for helping make our stay comfortable!"

Other attractions near St. Louis Science Center

A modern building with large glass windows and a garden with red and pink tulips.

Jewel Box

Made of stacked glass in a restored art deco style, this glass house from the 1930s continues to flourish with tropical trees, hanging plants and a large fountain.

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Frequently asked questions

What's the area like around St. Louis Science Center?

St. Louis Science Center is located in a welcoming area of St. Louis known for its picturesque gardens and sporting events. If you're looking for a convenient place to stay, check out the 74 hotels and other accommodations you'll find within a mile.

Where is the best place to stay near St. Louis Science Center?

Hampton Inn & Suites St. Louis at Forest Park is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.6 mi (1 km) from St. Louis Science Center. Other good options within a short distance include Home2 Suites by Hilton St. Louis/Forest Park and DoubleTree by Hilton St. Louis Forest Park.

How many hotels will I be able to find near St. Louis Science Center?

Expedia has 74 hotels and other accommodations within a mile from St. Louis Science Center.

If I need to cancel the hotel reservation for my stay near St. Louis Science Center, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available near St. Louis Science Center.

Where can I learn more about changing or cancelling my trip in the area near St. Louis Science Center?

To access more information about changing or cancelling your stay near St. Louis Science Center, go to https://www.expedia.com/service/.

What can I see and do near St. Louis Science Center?

Cathedral Basilica of St. Louis, St. Louis Art Museum, and City Museum feature captivating exhibits. St. Louis Union Station, Jewel Box, and Cherokee Street are monuments to see when you're exploring the area around St. Louis Science Center. You can check out the local talent at The Muny Theater, Fox Theater, and St. Louis Symphony Orchestra.

Find hotels near St. Louis Science Center, St. Louis from ￥13,818

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Our top choices for St. Louis Science Center hotels

1. Drury Inn & Suites St. Louis Forest Park

2. Hampton Inn & Suites St. Louis at Forest Park

3. The Royal Sonesta Chase Park Plaza St. Louis

4. AC Hotel St. Louis Central West End

5. Hotel Indigo St Louis - Central West End by IHG

6. Element by Marriott St. Louis Midtown

7. The West End

8. Home2 Suites by Hilton St. Louis/Forest Park

9. Aloft by Marriott St Louis Central West End

10. DoubleTree by Hilton St. Louis Forest Park

11. White House at Grand Central

12. Central West End B&B

13. Forest Park Hotel by MDR

14. Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave

15. Truitt Hotel

16. Drury Plaza Hotel St. Louis at the Arch

17. Drury Plaza Hotel St. Louis Brentwood

18. Pear Tree Inn St. Louis Airport

19. Benton Park Inn

20. The Lodge at Grant's Trail

Compare popular hotels close to St. Louis Science Center

Top St. Louis Science Center Hotel Reviews

Home2 Suites by Hilton St. Louis/Forest Park

Other attractions near St. Louis Science Center

Jewel Box

Frequently asked questions