St. Ann Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 10 - Dec 11
Tomorrow
Dec 11 - Dec 12
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

Our top choices for St. Ann vacation rentals

Microwave, oven, stovetop
Quaint 2-bedroom houseless than 10 minutes from The airport

Vacation Home in Saint Ann

Quaint 2-bedroom houseless than 10 minutes from The airport
The price is ￥14,114
￥35,967 total
includes taxes & fees
Dec 12 - Dec 13
Quaint 2-bedroom houseless than 10 minutes from The airport
Comfort Apartment | Individually decorated, individually furnished, desk, laptop workspace
White House at Grand Central

Apartment in Grand Center

White House at Grand Central
4.0 star property
8.6 out of 10, Excellent, (124)
"Very clean and very friendly people "
United States
Mary
The price is ￥10,718
￥22,552 total
includes taxes & fees
Jan 6 - Jan 7, 2026
White House at Grand Central
Outdoor dining
The St. Charles Guest House, lovely historic home, fun for families and groups

Vacation Home in St. Charles Historic District

The St. Charles Guest House, lovely historic home, fun for families and groups
10.0 out of 10, Exceptional, (136)
"We loved staying here in this adorable clean house that was only 1 block off of downtown Main Street shopping. "
United States
Lisa S.
The St. Charles Guest House, lovely historic home, fun for families and groups
Studio Suite, 1 King Bed | Desk, laptop workspace, blackout drapes, WiFi
Value Suites Extended Stay - St Louis

Aparthotel in Maryland Heights

Value Suites Extended Stay - St Louis
3.0 star property
7.0 out of 10, Good, (1110)
"We’ve stayed here twice before and have always been pleased with everything. Very good hotel close to what we need."
United States
Timothy
The price is ￥54,726
￥76,332 total
includes taxes & fees
Dec 18 - Dec 19
Value Suites Extended Stay - St Louis
Fridge, microwave, oven, stovetop
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!

Vacation Home in The Hill

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
9.8 out of 10, Exceptional, (160)
"Very clean, check in was easy, great neighborhood with lots of food close. "
United States
Laura H.
The price is ￥11,997
￥21,042 total
includes taxes & fees
Dec 14 - Dec 15
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
Microwave, oven, stovetop, dishwasher
Stunning 1890's Home - Sleeps 8!

Vacation Home in St. Charles Historic District

Stunning 1890's Home - Sleeps 8!
10.0 out of 10, Exceptional, (100)
"Check-in was easy and the house was lovely "
United States
Delfino A.
The price is ￥22,425
￥53,342 total
includes taxes & fees
Dec 23 - Dec 24
Stunning 1890's Home - Sleeps 8!
Microwave, oven, stovetop, dishwasher
Stylish City Reno Retreat!

Apartment in Hyde Park

Stylish City Reno Retreat!
6.4 out of 10, (15)
"We were pleased with our stay and would stay again"
United States
Nicole L.
Stylish City Reno Retreat!
Interior
Luxury 2BEDROOM LOFT near Bush Stadium

Apartment in Downtown St. Louis

Luxury 2BEDROOM LOFT near Bush Stadium
9.4 out of 10, Exceptional, (6)
"The location was perfect to access all things Downtown! The space was clean and well furnished. Check in/out was a breeze and the included parking spot was a huge plus for us! Great place to stay! "
United States
Kelci Y.
Luxury 2BEDROOM LOFT near Bush Stadium
Outdoor dining
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

Cottage in St. Charles Historic District

1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
10.0 out of 10, Exceptional, (210)
"Nice view of the Mississippi in the morning. Just off of the main street in old town St Charles, this place was perfect for our needs."
United States
Ralph
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Smart TV
Cozy Clark Suite in Frenchtown Saint Charles

Apartment in St. Charles Historic District

Cozy Clark Suite in Frenchtown Saint Charles
9.6 out of 10, Exceptional, (14)
"Awesome place to stay"
United States
paul
The price is ￥10,585
￥38,499 total
includes taxes & fees
Dec 11 - Dec 12
Cozy Clark Suite in Frenchtown Saint Charles
Fridge, microwave, oven, stovetop
St. Charles 1860's Gem - Sleeps 6!

Vacation Home in St. Charles Historic District

St. Charles 1860's Gem - Sleeps 6!
9.8 out of 10, Exceptional, (134)
"This was such a cute historical home and was perfect for our weekend in St Charles!"
United States
Isabelle C.
The price is ￥20,562
￥40,792 total
includes taxes & fees
Jan 1 - Jan 2, 2026
St. Charles 1860's Gem - Sleeps 6!
Outdoor dining
Honky Tonk Hideaway

Vacation Home in St. Charles Historic District

Honky Tonk Hideaway
8.8 out of 10, Excellent, (12)
"Great location close to historic district."
United States
Hugh S.
The price is ￥14,114
￥46,152 total
includes taxes & fees
Dec 11 - Dec 12
Honky Tonk Hideaway
Fridge, microwave, oven, stovetop
Home Near Main Street-Covered Patio-Hot Tub!

Vacation Home in Saint Charles

Home Near Main Street-Covered Patio-Hot Tub!
9.8 out of 10, Exceptional, (26)
"The place was great! "
United States
Melissa I.
The price is ￥30,188
￥70,903 total
includes taxes & fees
Dec 11 - Dec 12
Home Near Main Street-Covered Patio-Hot Tub!
2 bedrooms, desk, iron/ironing board, travel crib
Madison House 1 -Walk to Main St

Vacation Home in St. Charles Historic District

Madison House 1 -Walk to Main St
8.6 out of 10, Excellent, (14)
"The house was clean and well stocked, location was great, and plenty of street parking. "
United States
Brad K.
The price is ￥13,957
￥37,552 total
includes taxes & fees
Dec 14 - Dec 15
Madison House 1 -Walk to Main St
Dining
Tamm Ave 3-BR Retreat

Vacation Home in Dogtown

Tamm Ave 3-BR Retreat
9.6 out of 10, Exceptional, (48)
"The host was amazing with communication and checking in on how things were going. Property is in a good location and not too far from major attractions. Street of residence is a pretty narrow two way street so vehicles larger than a sedan may have some challenges coming and going. Overall a nice, quiet place to stay!"
United States
Yashika T.
Tamm Ave 3-BR Retreat
Fridge, microwave, oven, coffee/tea maker
Stylish South City King 1BR Apt

Apartment in Marine Villa

Stylish South City King 1BR Apt
2.0 star property
10.0 out of 10, Exceptional, (9)
"Great location, great accommodations, great host."
United States
Scott W.
The price is ￥12,546
￥27,999 total
includes taxes & fees
Dec 11 - Dec 12
Stylish South City King 1BR Apt
Interior
Residence on the Roundabout

Vacation Home in St Charles

Residence on the Roundabout
9.4 out of 10, Exceptional, (144)
"House was very nice. Pictures were good and we knew what to expect. Location was great for where we wanted to go.Owner was punctual when we had any questions!"
United States
Anne L.
Residence on the Roundabout
Fridge, microwave, oven, stovetop
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

Vacation Home in St. Charles Historic District

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
9.8 out of 10, Exceptional, (61)
"We had a great weekend and enjoyed the house very much! We had everything we needed!"
United States
Laurie S.
The price is ￥25,875
￥65,903 total
includes taxes & fees
Dec 11 - Dec 12
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
2 bedrooms, desk, iron/ironing board, free WiFi
The Otter Suite at Divine Otter

Aparthotel in St. Charles Historic District

The Otter Suite at Divine Otter
9.0 out of 10, Wonderful, (7)
"We absolutely loved this place! I would recommend this place. We had one issue but it was resolved. If you have children, I would probably stay somewhere else. There are bars all around and gets loud at night but it does get really quiet after 1:30 a.m. The property manager was absolutely amazing and is very quick to respond to your needs. "
United States
kim F.
The Otter Suite at Divine Otter
Terrace/patio
Brand New! Soulard Charmer - Pet Friendly.

Vacation Home in Soulard

Brand New! Soulard Charmer - Pet Friendly.
9.6 out of 10, Exceptional, (24)
"This house was beautiful and in a very nice spot in St. Louis. Close to everything and the hosts were amazing. Would definitely use again "
United States
Justin B.
The price is ￥20,465
￥40,852 total
includes taxes & fees
Dec 11 - Dec 12
Brand New! Soulard Charmer - Pet Friendly.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top St. Ann Hotel Reviews

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"Clean room, good breakfast and good location "
Martin 2-night trip
Posted 1 day ago
Clayton Plaza Hotel & Extended Stay

Find out more about St. Ann

Search for holiday rentals in St. Ann on Expedia! You can easily find your home rentals, villas, holiday apartments in St. Ann using one of the methods below:

  • View our selection of featured holiday rentals in St. Ann
  • Use the map to find apartments and other holiday homes in the St. Ann neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in St. Ann while they last

Look no further and take a look at our great range of rental properties in St. Ann!

Frequently asked questions

Are there vacation rentals in St. Ann?

Yes, we give you a choice of vacation rentals close to top sights in St. Ann, or you can choose a secluded option if you want a relaxing place to stay. Our travelers say St. Ann has a good selection of restaurants and the bars. Make sure you have time to check out the baseball games and shopping during your trip.

What are some of the best vacation home rentals in St. Ann?

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!: This vacation home rental near St. Ann is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a selection of games.

How many vacation rentals are there in St. Ann?

With 9 Expedia vacation rentals, you're sure to find just the right place for your St. Ann stay.

What can I see and do in St. Ann?

While exploring the area, visit family-friendly sights like Centene Community Ice Center, or get outside and enjoy nature at Lou Fusz Soccer Complex. While in the area, you can also visit popular places like St. Louis Union Station and Gateway Arch.

What are vacation rentals like in St. Ann?

Vacation rentals are private properties you can stay in for several days or more in St. Ann. Vacation rentals feature extras like kitchens and laundry facilities so you'll have all the conveniences of home. If you're concerned about a sanitized environment, vacation rentals can provide a sense of security away from shared hotel elevators and busy front desks while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a hotel, which makes a vacation rental a great choice for a family getaway.