Hotels near San Diego Santa Fe Depot

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Dec 13 - Dec 14
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Dec 14 - Dec 15
Next weekend
Dec 19 - Dec 21
In two weeks
Dec 26 - Dec 28

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Our top choices for San Diego Santa Fe Depot hotels

Memory foam beds, blackout drapes, iron/ironing board, free WiFi
Stay Classy Hostel

Stay Classy Hostel

Stay Classy Hostel
2.0 star property
East Village, 1.8 km from San Diego Santa Fe Depot
9.6 out of 10, Exceptional, (785)
"Good place to stay "
United States
sai
The price is ￥7,939
￥9,031 total
includes taxes & fees
Dec 15 - Dec 16
Stay Classy Hostel
Exterior
City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
1.9 km from San Diego Santa Fe Depot
9.6 out of 10, Exceptional, (105)
"would definitely go back and stay there again "
United States
Kounwick
The price is ￥15,160
￥22,392 total
includes taxes & fees
Dec 18 - Dec 19
City24 Hotel Little Italy Mission Hills
Restaurant
Crown City Inn

Crown City Inn

Crown City Inn
2.5 star property
2.7 km from San Diego Santa Fe Depot
9.6 out of 10, Exceptional, (652)
"Clean, friendly place at a nice price in a wonderful location."
United States
Scott
The price is ￥25,237
￥27,761 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Crown City Inn
Premium bedding, pillowtop beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 1.1 km from San Diego Santa Fe Depot
9.4 out of 10, Exceptional, (1001)
"Great location "
United States
Mohammad
The price is ￥13,452
￥20,100 total
includes taxes & fees
Dec 16 - Dec 17
Staypineapple, Hotel Z, Gaslamp San Diego
Meeting facility
Springhill Suites San Diego Downtown/Bayfront

Springhill Suites San Diego Downtown/Bayfront

Springhill Suites San Diego Downtown/Bayfront
3.5 star property
0.2 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (1003)
"Great place to stay"
United States
Kimberly
The price is ￥29,292
￥34,035 total
includes taxes & fees
Dec 20 - Dec 21
Springhill Suites San Diego Downtown/Bayfront
Meeting facility
Residence Inn by Marriott San Diego Downtown/Bayfront

Residence Inn by Marriott San Diego Downtown/Bayfront

Residence Inn by Marriott San Diego Downtown/Bayfront
3.0 star property
0.2 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (639)
"Really enjoyed the breakfast! Location was great and overall great stay! Hope to be back sometime in the next year coming up! "
United States
Omar
The price is ￥32,416
￥37,651 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Residence Inn by Marriott San Diego Downtown/Bayfront
Exterior
InterContinental San Diego by IHG

InterContinental San Diego by IHG

InterContinental San Diego by IHG
4.0 star property
0.2 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (1117)
"Room was great, the amenities great, overall very nice. "
United States
Crystal
The price is ￥33,032
￥47,336 total
includes taxes & fees
Dec 17 - Dec 18
InterContinental San Diego by IHG
2 outdoor pools, open 6 AM to 10:00 PM, cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 0.9 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (1947)
"Great hotel"
United States
Farzana
The price is ￥24,774
￥36,918 total
includes taxes & fees
Dec 20 - Dec 21
Marriott Marquis San Diego Marina
Exterior
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
4.0 star property
Gaslamp Quarter, 0.8 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (618)
"Welcome drink and breakfast were a nice treat."
United States
Mona
The price is ￥23,216
￥26,917 total
includes taxes & fees
Dec 21 - Dec 22
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
Standard Quadruple Room, Mixed Dorm | Shared kitchen facilities | Shared fridge, microwave, stovetop, toaster
Gaslamp Hostel

Gaslamp Hostel

Gaslamp Hostel
2.0 star property
Gaslamp Quarter, 0.9 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (536)
"Never had this much fun in time of a simple night stay! Great accessibility as well. "
United States
Dulce de la
Gaslamp Hostel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top San Diego Santa Fe Depot Hotel Reviews

Sheraton San Diego Resort

Sheraton San Diego Resort

10/10 Excellent
"Close to the airport. Very nice hotel. Easy uber to the city."
Zoran 2-night trip
Posted 13 hours ago
Sheraton San Diego Resort

Find out more about San Diego Santa Fe Depot

San Diego Santa Fe Depot hotels information

Number of reviews
8,377
Accommodation
3,914 hotels
Lowest Price
￥9,031
Highest Price
￥47,336

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Frequently asked questions

What's the area like around San Diego Santa Fe Depot?

San Diego Santa Fe Depot is located in a scenic area of San Diego known for its array of dining options and popular zoo. If you're looking for a convenient place to stay, check out the 836 hotels and other accommodations located within a mile of the station.

What's the best hotel to stay close to San Diego Santa Fe Depot?

The DEXTRO Little Italy, BW Premier Collection is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. It's located just a short 0.5 mi (0.9 km) from San Diego Santa Fe Depot. Another good option is Hard Rock Hotel San Diego, located just 0.8 mi (1.3 km) away.

How many hotels will I find close to San Diego Santa Fe Depot?

Expedia has 836 hotels and other accommodations within a mile from the station.

What can I see and do near San Diego Santa Fe Depot?

Study the collections at USS Midway Museum, Maritime Museum of San Diego, or San Diego Air and Space Museum. Hotel del Coronado, Star of India, and California Tower are monuments to see when you're exploring the area around San Diego Santa Fe Depot. You can watch performances at San Diego Civic Theatre, The Rady Shell at Jacobs Park, and Old Globe Theater if you're interested in local theater.