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Our top choices for Northwest Alabama hotels

A hotel lobby with a seating area, a reception desk, and a check-in counter.

1. Residence Inn Florence Marriott

East Florence

Nathan

￥22,052 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with a bed, a desk, a chair, a mirror, a painting, and a nightstand with a lamp.

2. Days Inn by Wyndham Muscle Shoals Florence

Muscle Shoals

Shana

￥12,448 total

includes taxes & fees

Dec 7 - Dec 8

A modern kitchen with wooden cabinets, a countertop with various appliances, and a view of the outdoors.

3. Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG

Florence

LaRhonda

￥19,136 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a blue sofa, a wooden table, and chairs. There is a TV on a stand and a painting on the wall.

4. Hampton Inn & Suites Florence-Downtown

Florence

Heather

￥29,845 total

includes taxes & fees

Nov 29 - Nov 30

An indoor swimming pool with tiled steps and a sunlit room with chairs and a window.

5. Comfort Suites Florence Shoals Area

Florence

Elizabeth

￥15,586 total

includes taxes & fees

Nov 29 - Nov 30

A spacious lobby with a reception desk, seating area, and a balcony.

6. Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites

Tuscumbia

Colin

￥17,965 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a bed, a desk with chairs, a small kitchenette, and a TV.

7. Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

Tuscumbia

Brian

￥11,064 total

includes taxes & fees

Nov 10 - Nov 11

A hotel with a large pool area, a water tower, and a dome structure.

8. Renaissance Shoals Resort & Spa

East Florence

Christina

￥48,720 total

includes taxes & fees

Dec 7 - Dec 8

A bedroom with a brick wall, a dark blue headboard, and patterned pillows.

9. The Stricklin Hotel

Florence

Dana

￥27,832 total

includes taxes & fees

Dec 7 - Dec 8

A spacious interior with a central staircase, a chandelier, and a view to the outdoors.

10. Spark by Hilton Tuscumbia Muscle Shoals

Tuscumbia

Patrick

￥14,653 total

includes taxes & fees

Nov 29 - Nov 30

A spacious lobby with seating areas, a reception desk, and large windows.

11. Clarion Inn Sheffield Muscle Shoals

Sheffield

Billy

￥13,615 total

includes taxes & fees

Dec 1 - Dec 2

A modern living room with a sofa, armchairs, a coffee table, and a TV.

12. Baymont by Wyndham Florence/Muscle Shoals

Florence

Alan

￥12,315 total

includes taxes & fees

Dec 7 - Dec 8

A spacious lounge with a fireplace, leather sofas, and a bar area.

13. GunRunner Boutique Hotel

Florence

John M

￥33,286 total

includes taxes & fees

Dec 8 - Dec 9

A modern hotel room with a large bed, a desk, a chair, a window with a view, and a wall-mounted lamp.

14. Hampton Inn Florence Midtown near University of North Alabama

Florence

calvin

￥23,614 total

includes taxes & fees

Dec 6 - Dec 7

A hotel room with a bed, a desk with a lamp, a TV, a sofa, and a view of greenery outside.

15. Comfort Inn & Suites Tuscumbia - Muscle Shoals

Tuscumbia

David

￥17,801 total

includes taxes & fees

Dec 6 - Dec 7

A spacious living area with a staircase, a flat-screen TV, and a seating area with a coffee table.

16. Best Western Plus Russellville Hotel & Suites

Russellville

Dennis

￥18,812 total

includes taxes & fees

Nov 25 - Nov 26

A modern hotel room with a large bed, a separate sitting area, a bathtub, and a view of the outdoors.

17. Red Roof Inn Muscle Shoals

Muscle Shoals

Keith

￥10,342 total

includes taxes & fees

Nov 9 - Nov 10

A hotel room with a bed, a desk, a chair, a nightstand, a lamp, a painting of a sunset, and a bathroom with a mirror and sink.

18. Days Inn by Wyndham Moulton

Moulton

Debra

￥11,114 total

includes taxes & fees

Nov 15 - Nov 16

A reception area with a reception desk, a seating area with chairs and a table, a plant, a lamp, a bulletin board, and a window with a view of the outside.

19. Keywest Inn - Tuscumbia/Muscle Shoals

Tuscumbia

Barbara

￥13,193 total

includes taxes & fees

Nov 8 - Nov 9

A reception area with a stone wall, a reception desk, and a door leading outside.

20. Econo Lodge Russellville

Russellville

Mark

￥12,215 total

includes taxes & fees

Nov 15 - Nov 16

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Vacation Rentals in Northwest Alabama

Cottage

A living room with a ceiling fan, a television, a leather sofa, and a wooden cabinet.

Killen Vacation Rental ~ 4 Mi to Wilson Lake!

Killen

"Great place to stay. "

Cottage

A spacious living area with a dining table, chairs, a TV, and a kitchen area with cabinets and appliances.

A-frame Home ~ 6 Mi to Tennessee River!

Florence

"Cute cottage close to all amenities."

Cottage

A covered patio with wicker furniture, a brick wall, and a view of the garden.

Charming Florence Getaway w/ Fireplace & Grill!

Florence

"The house was beautiful, clean, spacious, and very comfortable. It had all the amenities you could want and need. It was a quiet and nice neighborhood and close to dining and shopping. The owner kept in touch with us the entire stay and was very kind. We will definitely stay there again!"

Cottage

A modern kitchen with granite countertops, a stone backsplash, a built-in oven, and a large window overlooking a garden.

Expansive Florence Home ~ 6 Mi to Downtown!

Florence

"Our family totally loved staying here - close where we needed to be and we were so comfortable - especially with 3 bathrooms for 3 bedrooms! Loved it!"

Cottage

A modern living room with a blue leather sofa, two brown leather armchairs, a small round table, and a staircase leading to the upper floor.

7 Mi to Tennessee River: Home w/ Patio in Florence

Florence

"We loved the place huge rooms we had 10 people and had plenty of room .We would stay again but floors needed sweep and mopped but overall it was a great place ."

Cottage

A sunroom with a glass door, a ceiling fan, a hanging chair, and a view of the lake.

Waterfront Bliss: Wheeler Lake Retreat w/ Dock!

Athens

"Enjoyed your home"

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Stay near popular Northwest Alabama attractions

Dismals Canyon

9.0/10 (35 reviews)

Commune with nature and explore the great outdoors at Dismals Canyon during your travels in Phil Campbell. While you're in the area, wander around the natural setting.

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Learn more about Northwest Alabama

Explore the family-friendly area of Northwest Alabama—live music, entertainment choices, and sights from Dismals Canyon to Cane Creek Canyon Nature Preserve.

See all hotels in Northwest Alabama

A waterfall cascading over rocks in a forested area.

Top Northwest Alabama Hotel Reviews

Spark by Hilton Tuscumbia Muscle Shoals

10/10 Excellent

"Just overall comfortable"

Hampton Inn & Suites Florence-Downtown

10/10 Excellent

"This is the second time I stayed at this hotel, and I like it. I like the staff, the amenities, the location, and the convenience. I did pay a lot more this time for a room, though, and when I asked about it, I was told that it was because it was on Halloween night. Seems a little uncouth to raise the price of the room that much because it was Halloween."