Isle of Palms Vacations

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Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms
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Southside

3 out of top 10 points of interest in this area
4/5(912 area reviews)

If you're spending some time in Southside, St. Johns Town Center and The Avenues are top sights worth seeing.

Find hotels in Southside

Isle of Palms Hotel Deals

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3 out of 5
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
Fully refundableReserve now, pay when you stay
The price is ￥25,757 per night from Sep 12 to Sep 13
￥25,757
￥29,234 total
Sep 12 - Sep 13
includes taxes & fees
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
9/10 Wonderful! (3,031 reviews)
"The property was so beautiful, so relaxing and such a breathe of fresh air. It was a well needed Mom-daughter getaway that was so beautiful. The staff was lovely and so kind and there were plenty of dinner options in the area, just be weary there’s no microwave on the property so don’t bring too ..."

Reviewed on Sep 1, 2025

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Margaritaville Jacksonville Beach
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr, Jacksonville, FL
Fully refundableReserve now, pay when you stay
The price is ￥23,254 per night from Sep 3 to Sep 4
￥23,254
￥26,658 total
Sep 3 - Sep 4
includes taxes & fees
Hyatt Regency Jacksonville
See all 3,113 properties in Isle of Palms
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Isle of Palms vacation package cost?
Starting from as low as , you can build your own Isle of Palms vacation package. Simply bundle flights, hotels and car rentals and be rewarded with discounts.
How do I get a cheap travel package to Isle of Palms?
If you love getting a great deal, bundle your bookings into an Isle of Palms vacation package. Whether you need hotels, flights, day tours or rental cars, you can book them all in one place. You'll have ample choice at your fingertips too. Expedia has over 550 air carriers and 1,000,000 hotels all over the world to take your pick of. Fly with who you prefer, stay wherever you like and save precious money — now that's the ideal escape!
Where should I stay in Isle of Palms?
Make sightseeing a breeze by staying someplace right around the corner from Isle of Palms's big attractions. St. Johns Town Center and University of North Florida are two traveler favorites.
What are the top hotels in Isle of Palms?
Get your trip off to a great start by locking in a room at The Retreat Close To Mayo Clinic. It's one of most sought-after hotels in Isle of Palms. Another top option is Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How far in advance should I book my Isle of Palms vacation?
Your best bet is to book early. Airlines usually advertise flights nearly 12 months prior to departure, and this is a perfect opportunity to land some of the lowest prices. Boss just told you to take your vacation time next week? No sweat. Expedia are never short on fantastic deals to whisk you away on the getaway of your dreams, at a price you can afford.
What does an Expedia Isle of Palms travel package include?
From hotels and flights to car rentals, Expedia can help you shape an Isle of Palms package that's perfect for you. Vacationing for a while? Look into a rental car, flight and hotel bundle. If you can only squeeze in a quick getaway, a hotel and airfare deal could suit you better. Experiences can also be added once you've made your booking. Our vacation packages make it a breeze to save and plan.
What should I know before booking an Isle of Palms travel package?
A travel package can be easier on the hip pocket than individually booking everything you need for your adventure. For example, bundle your hotels, flights and rental cars and save a pretty penny. Whatever sort of vacation you're planning, there's sure to be a package that matches your budget.
Can I choose my airline with an Isle of Palms Expedia vacation package?
Yes, the choice is all yours. We have access to over 550 partner airlines throughout the world, so you can design your Isle of Palms trip according to your travel needs.
If I'm not able to travel, can I cancel my Isle of Palms vacation package?
Because we understand life is full of surprises, the answer is yes. To find out more, check out our Customer Service Portal. But generally speaking, if you've booked your package in the last 24 hours, you may be able to cancel or change it with no penalties. Your airline, hotel or car rental company may charge a fee if your booking is older than that.

Discover the most popular places to visit in Isle of Palms

Pretty

Mayo Clinic Florida

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
Jacksonville Naval Air Station

Jacksonville Naval Air Station

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the great live music or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station
Jacksonville Zoo and Gardens showing zoo animals

Jacksonville Zoo and Gardens

Admire thousands of animals and plants across entertaining exhibits in this family-friendly zoo that also has a children’s play area and a 4-D experience.

Jacksonville Zoo and Gardens

Things to do

3 Hour Coastal Fun Cruise

3 Hour Coastal Fun Cruise

￥22,170
per adult
3 Hour Coastal Fun Cruise
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

￥20,692
per traveler
90% of travellers recommend
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
Chocolate Bar Class

Chocolate Bar Class - Hands on class

￥2,956
per adult
Chocolate Bar Class - Hands on class
See all activities in Jacksonville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.