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May 9 - May 10
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May 10 - May 11
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May 15 - May 17
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May 22 - May 24

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Our top choices for Isle of Palms hotels

Lobby lounge

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms
9.4 out of 10, Exceptional, (503 reviews)
"Great place to stay!"
United States
Chad
The price is ￥21,708
￥24,639 total
includes taxes & fees
May 30 - May 31
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Lounge

AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
2.5 star property
9.1 km from Isle of Palms
9.4 out of 10, Exceptional, (194 reviews)
"Great hotel! Clean, modern, new and EV charging was a HUGE plus. Would definitely stay here again "
United States
Colton
The price is ￥28,046
￥31,832 total
includes taxes & fees
May 10 - May 11
AC Hotel Jacksonville St Johns Town Center
Restaurant

Extended Stay America Premier Suites - Jacksonville - Airport

Extended Stay America Premier Suites - Jacksonville - Airport
2.5 star property
30.8 km from Isle of Palms
8.8 out of 10, Excellent, (397 reviews)
"Nice place to stay "
United States
Tanya
The price is ￥12,690
￥14,403 total
includes taxes & fees
May 11 - May 12
Extended Stay America Premier Suites - Jacksonville - Airport
Premium bedding, desk, blackout drapes, iron/ironing board

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin
3.0 star property
21.3 km from Isle of Palms
7.6 out of 10, Good, (471 reviews)
"The property was very clean and the staff was very nice. Breakfast was delicious "
United States
Jose
The price is ￥12,119
￥13,755 total
includes taxes & fees
May 28 - May 29
La Quinta Inn & Suites by Wyndham Jacksonville Mandarin
Exterior

Seahorse Oceanfront Inn

Seahorse Oceanfront Inn
2.5 star property
6.7 km from Isle of Palms
8.8 out of 10, Excellent, (686 reviews)
"Rooms and the staff were very nice "
United States
Brant
The price is ￥18,880
￥24,985 total
includes taxes & fees
May 20 - May 21
Seahorse Oceanfront Inn
Terrace/patio

Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
9.1 km from Isle of Palms
10.0 out of 10, Exceptional, (13 reviews)
"Clean rooms ,pet friendly,friendly staff"
United States
Theresa
The price is ￥18,512
￥21,012 total
includes taxes & fees
Jun 1 - Jun 2
Hyatt Studios Jacksonville/St Johns Town Center
Terrace/patio

Home2 Suites By Hilton Jacksonville Downtown

Home2 Suites By Hilton Jacksonville Downtown
3.0 star property
24.4 km from Isle of Palms
9.2 out of 10, Wonderful, (327 reviews)
"Inexpensice, clean, nice place to stay. Would stay here again"
United States
donna
The price is ￥21,070
￥23,914 total
includes taxes & fees
May 17 - May 18
Home2 Suites By Hilton Jacksonville Downtown
Exterior

Holiday Inn Express Jacksonville - Blount Island by IHG

Holiday Inn Express Jacksonville - Blount Island by IHG
2.5 star property
20.3 km from Isle of Palms
8.8 out of 10, Excellent, (1,009 reviews)
"Typical Holiday Inn , very nice but not over the top."
United States
Gary
The price is ￥16,451
￥18,673 total
includes taxes & fees
May 13 - May 14
Holiday Inn Express Jacksonville - Blount Island by IHG
Free daily buffet breakfast

Wingate by Wyndham Jacksonville FL

Wingate by Wyndham Jacksonville FL
3.0 star property
15.4 km from Isle of Palms
7.4 out of 10, Good, (1,007 reviews)
"The staff at this hotel were very friendly and accommodating. The room was comfortable and very clean, though the curtain was short and allowed a lot of sunlight in at sunup."
United States
Josie
The price is ￥11,163
￥12,671 total
includes taxes & fees
May 17 - May 18
Wingate by Wyndham Jacksonville FL
Exterior

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,095 reviews)
"Great place to stay"
United States
Jeffrey
The price is ￥22,582
￥25,631 total
includes taxes & fees
May 31 - Jun 1
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Room, 2 Queen Beds, Balcony, Oceanfront (Balcony) | Premium bedding, in-room safe, desk, laptop workspace

Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
5 km from Isle of Palms
8.4 out of 10, Very Good, (1,010 reviews)
"Ocean view is Amazing! Close to many great restaurants."
United States
Sandra
The price is ￥27,106
￥30,765 total
includes taxes & fees
May 28 - May 29
Courtyard by Marriott Jacksonville Beach Oceanfront
Breakfast, lunch, dinner served; American cuisine

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
2.1 km from Isle of Palms
9.4 out of 10, Exceptional, (221 reviews)
"It was a very nice hotel , would recommend for any one 👌 "
United States
Michael
The price is ￥25,567
￥29,019 total
includes taxes & fees
May 29 - May 30
Hilton Jacksonville At Mayo Clinic
Lobby

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
4.6 km from Isle of Palms
9.0 out of 10, Wonderful, (3,944 reviews)
"Great staff, hotel was cleaned, food was wonderful!!! "
United States
tuwanna
The price is ￥26,651
￥30,250 total
includes taxes & fees
May 12 - May 13
Margaritaville Jacksonville Beach
Lobby

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1,007 reviews)
"Very enjoyable stay!"
United States
Kristin
The price is ￥23,339
￥26,023 total
includes taxes & fees
May 25 - May 26
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Breakfast area

Tru by Hilton Jacksonville Airport I-95

Tru by Hilton Jacksonville Airport I-95
2.5 star property
31.5 km from Isle of Palms
9.4 out of 10, Exceptional, (1,054 reviews)
"We love this place, great large rooms and welcoming atmosphere......great breakfast. "
United States
Billie
The price is ￥12,989
￥14,742 total
includes taxes & fees
May 31 - Jun 1
Tru by Hilton Jacksonville Airport I-95
On the beach

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
4.4 km from Isle of Palms
9.0 out of 10, Wonderful, (1,013 reviews)
"Great distance of beach clean rooms great breakfast loved it here"
United States
LaTevia
The price is ￥22,059
￥25,037 total
includes taxes & fees
May 17 - May 18
Best Western Oceanfront
41-inch Smart TV with cable channels

Weekly Inn

Weekly Inn
2.0 star property
14.9 km from Isle of Palms
7.6 out of 10, Good, (1,260 reviews)
"This place is a gem. Price and comfort and an ideal location "
United States
andrew
The price is ￥7,626
￥8,655 total
includes taxes & fees
May 13 - May 14
Weekly Inn
Lobby sitting area

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.9 km from Isle of Palms
8.8 out of 10, Excellent, (1,009 reviews)
"Great stay!"
United States
Satavia
The price is ￥14,916
￥16,930 total
includes taxes & fees
Jun 7 - Jun 8
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Exterior

Tru by Hilton Jacksonville South Mandarin

Tru by Hilton Jacksonville South Mandarin
2.5 star property
21.6 km from Isle of Palms
9.2 out of 10, Wonderful, (1,004 reviews)
"Definitely would stay again!!"
United States
Nyasia
The price is ￥15,029
￥17,058 total
includes taxes & fees
May 25 - May 26
Tru by Hilton Jacksonville South Mandarin
Reception

Hampton Inn Jacksonville East Regency Square

Hampton Inn Jacksonville East Regency Square
2.5 star property
13 km from Isle of Palms
8.8 out of 10, Excellent, (1,013 reviews)
"Breakfast was good. Parking good"
United States
Christopher
The price is ￥15,674
￥17,790 total
includes taxes & fees
May 24 - May 25
Hampton Inn Jacksonville East Regency Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most.
Fernandina Beach, Florida, USA Historic Downtown 1959

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.

Photo by Russell Hewatt
Open Photo by Russell Hewatt

Sawgrass

Visitors to Sawgrass like its beaches and riverfront, and Mickler Beach is a sight worth a stop.

Jacksonville Florida Skyline at Night

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

American Pitbull Terrier

American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

Top Isle of Palms Hotel Reviews

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

10/10 Excellent
"Clean room, helpful staff, and good complimentary breakfast. Complimentary shuttle to the Mayo Clinic too!!"
Lori 2-night trip
Posted 6 hours ago
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Frequently asked questions

What is Isle of Palms like?
Travelers are sure to enjoy a stay in Jacksonville Beach's Isle of Palms neighborhood.
What's a favorite place to stay in Isle of Palms?
Based on our traveler data, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is one of the top choices for your stay in Isle of Palms. This hotel offers free breakfast and an outdoor pool.
How many hotels can I expect to find in Isle of Palms?
Expedia has 42 hotels and other accommodations in Isle of Palms to choose from, making this an ideal home base for exploring the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?
Yes, you'll find most hotel reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get top deals in Isle of Palms.
Where can I learn more about changing or cancelling my trip to Isle of Palms?
For more information about changing or cancelling your trip to Isle of Palms, head over to our customer service page.
What is there to do in this Jacksonville Beach neighborhood?
A few places to visit in the area around Isle of Palms include Cradle Creek Preserve, Jacksonville Beach Golf Club, and Windsor Parke Golf Club. While you're out sightseeing in Jacksonville Beach, be sure to visit other sights like Players by the Sea or Rhoda Martin Cultural Heritage Center.