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Sep 25 - Sep 27
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Oct 2 - Oct 4

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Our top choices for Isle of Palms hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms
9.4 out of 10, Exceptional, (602 reviews)
"Great stay"
United States
Michaelanne
The price is ￥23,992
￥27,232 total
includes taxes & fees
Oct 25 - Oct 26
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
A hotel lobby with a bar area, seating arrangements, and a reception desk.

2. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
3 km from Isle of Palms
9.0 out of 10, Wonderful, (1,000 reviews)
"Great place to stay."
United States
Patsy
The price is ￥17,327
￥19,666 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

3. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
3 km from Isle of Palms
9.2 out of 10, Wonderful, (660 reviews)
"Great location close to the beach. Super well maintained facility. Everything was great!"
United States
gregory
The price is ￥18,737
￥21,266 total
includes taxes & fees
Oct 4 - Oct 5
TownePlace Suites by Marriott Jacksonville East
A lobby with a reception desk, seating area, and a staircase.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.9 km from Isle of Palms
9.0 out of 10, Wonderful, (1,007 reviews)
"wonderful breakfast and friendly staff"
United States
frances
The price is ￥14,719
￥16,707 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A modern restaurant with a bar area, wooden ceiling, and large windows.

5. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
2.1 km from Isle of Palms
9.4 out of 10, Exceptional, (360 reviews)
"Excellent hotel and staff."
United States
Kristen
The price is ￥28,552
￥32,407 total
includes taxes & fees
Oct 16 - Oct 17
Hilton Jacksonville at Mayo Clinic near Beaches
An outdoor patio with seating, a fire pit, and string lights.

6. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1,167 reviews)
"Great staff, great breakfast, and very clean."
United States
Marty
The price is ￥20,132
￥22,850 total
includes taxes & fees
Oct 1 - Oct 2
Hyatt Place Jacksonville / St. Johns Town Center
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

7. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.6 km from Isle of Palms
9.0 out of 10, Wonderful, (4,519 reviews)
"Great location with beautiful views, clean, beautiful rooms and lots to do around the area"
United States
Keisha
The price is ￥23,499
￥26,673 total
includes taxes & fees
Sep 28 - Sep 29
Margaritaville Jacksonville Beach
An outdoor patio area with wicker furniture, a fire feature, and string lights.

8. Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1,001 reviews)
"Good location, clean"
United States
Kerrie
The price is ￥19,472
￥22,100 total
includes taxes & fees
Sep 26 - Sep 27
Sheraton Jacksonville Hotel
A hotel room with a large bed, a desk with a chair, a television, and a mirror.

9. Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.8 km from Isle of Palms
8.6 out of 10, Excellent, (999 reviews)
"Great Hotel"
United States
Josh
The price is ￥13,136
￥14,909 total
includes taxes & fees
Oct 22 - Oct 23
Holiday Inn Jacksonville E 295 Baymeadows by IHG
A spacious lobby with a reception desk, seating area, and large windows.

10. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1,002 reviews)
"Great in every way!! Very comfortable and clean and friendly"
United States
Joyce
The price is ￥18,549
￥20,682 total
includes taxes & fees
Oct 19 - Oct 20
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
A self-service beverage station with a refrigerated display and a coffee machine.

11. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
2.5 star property
9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (961 reviews)
"Very convenient location and easy check in and out. Rooms were clean and quiet. Breakfast was great!"
United States
Mary
The price is ￥17,238
￥19,566 total
includes taxes & fees
Oct 4 - Oct 5
Tru By Hilton Jacksonville St Johns Town Center
A covered entrance with a dark tiled floor, white columns, and a green bench.

12. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,233 reviews)
"Room was clean, staff were very pleasant and helpful. Will definitely stay here again when I come back to Jacksonville."
United States
Robert
The price is ￥18,603
￥21,113 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
A beach with a sandy shore, waves, and buildings in the background.

13. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.4 km from Isle of Palms
9.0 out of 10, Wonderful, (1,002 reviews)
"This is one of the best kept Best Western hotels I’ve ever been in. The hotel is walkable to the beach, dining, and activities. Parking is easy. The staff are very friendly and breakfast was varied for everyone’s needs."
United States
Sonya
The price is ￥18,011
￥20,444 total
includes taxes & fees
Sep 30 - Oct 1
Best Western Oceanfront
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

14. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
3.3 km from Isle of Palms
9.2 out of 10, Wonderful, (1,001 reviews)
"The staff was nice, and the breakfast was very good,"
United States
Jose
The price is ￥18,579
￥21,088 total
includes taxes & fees
Oct 1 - Oct 2
Holiday Inn Express Jacksonville Beach by IHG
A hotel with a central building and two wings, featuring a well-lit entrance and a clear sky.

15. Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.

Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
3.0 star property
9.1 km from Isle of Palms
8.6 out of 10, Excellent, (1,001 reviews)
"Staff was ,polite and attentive, my four year old felt at home and loved breakfast. The friendliest stay we have had in a while. Highly recommended them."
United States
Maria
The price is ￥17,946
￥20,369 total
includes taxes & fees
Oct 4 - Oct 5
Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
A modern living room with a sectional sofa, a coffee table, and vibrant abstract art on the walls.

16. Weekly Inn

Weekly Inn
2.0 star property
14.9 km from Isle of Palms
7.8 out of 10, Good, (1,495 reviews)
"The property was quiet & was better than I expected for that price. Would stay here again."
United States
Tavares
The price is ￥6,581
￥7,470 total
includes taxes & fees
Sep 25 - Sep 26
Weekly Inn
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

17. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 4.2 km from Isle of Palms
9.6 out of 10, Exceptional, (587 reviews)
"Nice lodging a block from the beach. Great food nearby."
United States
Nick
The price is ￥23,932
￥27,164 total
includes taxes & fees
Oct 1 - Oct 2
Element by Marriott Jacksonville Beach

18. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
Oceanfront, 4.3 km from Isle of Palms
9.0 out of 10, Wonderful, (1,006 reviews)
"Awesome stay"
United States
Susan
The price is ￥27,971
￥31,747 total
includes taxes & fees
Oct 4 - Oct 5
Four Points by Sheraton Jacksonville Beachfront
A multi-story hotel with a modern design, featuring a prominent "HYATT PLACE" sign.

19. Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport
3.0 star property
31.1 km from Isle of Palms
9.0 out of 10, Wonderful, (2,573 reviews)
"Great stay"
United States
Tom
The price is ￥15,067
￥17,101 total
includes taxes & fees
Oct 1 - Oct 2
Hyatt Place Jacksonville Airport
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

20. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
8.9 km from Isle of Palms
9.4 out of 10, Exceptional, (214 reviews)
"Very nice stay, they have grab and go breakfast as complimentary."
United States
Phi
The price is ￥17,410
￥19,760 total
includes taxes & fees
Oct 3 - Oct 4
Hyatt Studios Jacksonville/St Johns Town Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms

Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most.
A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.

A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

A sunset over a beach with waves and a pier.

Oceanfront

If you're spending some time in Oceanfront, Oceanfront Park and Northeast Florida Beaches are top sights worth seeing.

A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

A sunset over a beach with fallen trees and a distant shoreline.

American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

Top Isle of Palms Hotel Reviews

Dune House Hotel & Spa

Dune House Hotel & Spa

10/10 Excellent
"Wonderful weekend getaway! Location was everything. Loved having chairs and umbrellas set up for me. Clean hotel and friendly staff. Will return"
mary 2-night trip
Posted 1 hour ago
Dune House Hotel & Spa

Frequently asked questions

What is Isle of Palms like?
Travelers are sure to enjoy a stay in Jacksonville Beach's Isle of Palms neighborhood.
What's a favorite place to stay in Isle of Palms?
Based on our traveler data, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is one of the top choices for your stay in Isle of Palms. This hotel is a short 6-minute walk from Mayo Clinic Florida, and it offers free breakfast and an outdoor pool.
How many hotels can I expect to find in Isle of Palms?
Expedia has 36 hotels and other accommodations in Isle of Palms to choose from, making this an ideal home base for exploring the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?
Yes, you'll find most hotel reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get top deals in Isle of Palms.
Where can I learn more about changing or cancelling my trip to Isle of Palms?
For more information about changing or cancelling your trip to Isle of Palms, head over to our customer service page.
What is there to do in this Jacksonville Beach neighborhood?
A few places to visit in the area around Isle of Palms include Cradle Creek Preserve, Jacksonville Beach Golf Club, and Windsor Parke Golf Club. While you're out sightseeing in Jacksonville Beach, be sure to visit other sights like Players by the Sea or Rhoda Martin Cultural Heritage Center.