The Best Hotels Closest to Buffalo Museum of Science in Buffalo for 2026

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Our top choices for Buffalo Museum of Science hotels

A historic building with a prominent tower and a traditional brick facade.

1. Buffalo Harmony House

Allentown, 3.2 km from Buffalo Museum of Science

John

￥59,358 total

includes taxes & fees

Dec 14 - Dec 15

A black sign with gold lettering for 'Buffalo Guesthouse' at 531 Franklin Street.

2. Buffalo Guesthouse

Allentown, 2.4 km from Buffalo Museum of Science

Jose

￥30,307 total

includes taxes & fees

Nov 14 - Nov 15

A grand entrance with a staircase leading to a door, surrounded by lush greenery and a well-maintained garden.

3. The Mansion On Delaware Ave

Allentown, 3 km from Buffalo Museum of Science

Marilyn

￥35,315 total

includes taxes & fees

Nov 19 - Nov 20

A modern building with a Starbucks on the ground floor, featuring large windows and a flat roof.

4. Residence Inn by Marriott Buffalo Downtown

Allentown, 2.6 km from Buffalo Museum of Science

Karen

￥34,724 total

includes taxes & fees

Nov 24 - Nov 25

A spacious lobby with a large sofa, a coffee table, and potted plants. There is a decorative wall with a painting and a large window providing natural light.

5. Wyndham Garden Buffalo Downtown

Downtown Buffalo, 1.9 km from Buffalo Museum of Science

Sara

￥28,382 total

includes taxes & fees

Nov 23 - Nov 24

A hotel room with a bed, desk, chair, TV, and a bathroom with a sink and mirror.

6. Best Western on the Avenue

Allentown, 2.8 km from Buffalo Museum of Science

James

￥26,714 total

includes taxes & fees

Dec 14 - Dec 15

A hotel lobby with seating areas, a reception desk, and large windows overlooking the street.

7. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Buffalo Theater District, 3.1 km from Buffalo Museum of Science

Daniel

￥20,890 total

includes taxes & fees

Dec 14 - Dec 15

A lobby with a staircase, seating area, and a view of the outdoors.

8. Lenox Hotel and Suites

Allentown, 2.6 km from Buffalo Museum of Science

Thomas

￥14,465 total

includes taxes & fees

Dec 6 - Dec 7

A modern hotel with a glass facade, multiple floors, and a prominent 'Aloft' sign.

9. Aloft by Marriott Buffalo Downtown

Buffalo Theater District, 3 km from Buffalo Museum of Science

Nicole

￥35,691 total

includes taxes & fees

Dec 6 - Dec 7

A buffet setup with various food items and utensils.

10. Salvatores Grand Hotel

13.1 km from Buffalo Museum of Science

karen

￥30,714 total

includes taxes & fees

Nov 22 - Nov 23

A spacious living area with a fireplace, a large sofa, and a dining area with a table and chairs.

11. Reikart House, Buffalo, a Tribute Portfolio Hotel

8.3 km from Buffalo Museum of Science

Jonathon

￥45,616 total

includes taxes & fees

Nov 29 - Nov 30

12. Hampton Inn Buffalo - Amherst, NY

10.6 km from Buffalo Museum of Science

Lee

￥20,700 total

includes taxes & fees

Nov 29 - Nov 30

A bedroom with a four-poster bed, a large window with a view of a body of water, and a flat-screen TV mounted on the wall.

13. Buffalo Marriott at LECOM HARBORCENTER

Downtown Buffalo, 4.4 km from Buffalo Museum of Science

Stephen

￥46,838 total

includes taxes & fees

Nov 19 - Nov 20

A breakfast buffet with various food items and beverages, a large window with a view of buildings, and a patterned floor.

14. Curtiss Hotel, an Ascend Collection Hotel

Buffalo Theater District, 3.4 km from Buffalo Museum of Science

John

￥47,442 total

includes taxes & fees

Dec 13 - Dec 14

A spacious lobby with modern furniture, large windows, and a high ceiling with exposed beams.

15. The Westin Buffalo

Buffalo Theater District, 3.3 km from Buffalo Museum of Science

Sarah

￥50,737 total

includes taxes & fees

Nov 23 - Nov 24

An outdoor patio area with brick walls, white columns, and a fire pit surrounded by wicker furniture.

16. Hilton Garden Inn Buffalo Airport

9.4 km from Buffalo Museum of Science

Kathleen

￥24,576 total

includes taxes & fees

Dec 6 - Dec 7

17. Tru by Hilton Williamsville Buffalo Airport

13 km from Buffalo Museum of Science

Colin

￥19,928 total

includes taxes & fees

Nov 30 - Dec 1

A historic building with a symmetrical facade, large arched windows, and a prominent central entrance.

18. The Richardson Hotel

Elmwood Bidwell, 4 km from Buffalo Museum of Science

Victoria

￥22,412 total

includes taxes & fees

Nov 29 - Nov 30

A Hyatt Place hotel with a modern facade, a well-lit entrance, and a parking lot.

19. Hyatt Place Buffalo/Amherst

8.4 km from Buffalo Museum of Science

Gifford

￥26,006 total

includes taxes & fees

Nov 16 - Nov 17

A modern kitchen with a central island, wooden cabinets, and a bar area with stools.

20. Springhill Suites Buffalo Airport

13 km from Buffalo Museum of Science

Feng

￥25,188 total

includes taxes & fees

Nov 29 - Nov 30

View all properties

Compare popular hotels close to Buffalo Museum of Science

Property	Star rating	Guest rating
Buffalo Harmony House	4.5 star property	10.0 Exceptional 58 reviews	View
Buffalo Guesthouse	4.0 star property	9.4 Exceptional 232 reviews	View
The Mansion On Delaware Ave	4.0 star property	9.4 Exceptional 1,000 reviews	View
Residence Inn by Marriott Buffalo Downtown	3.0 star property	9.2 Wonderful 390 reviews	View
Wyndham Garden Buffalo Downtown	3.0 star property	9.0 Wonderful 1,901 reviews	View

Hotels recommended for families near Buffalo Museum of Science

Wyndham Garden Buffalo Downtown

Downtown Buffalo

￥28,382 total

includes taxes & fees

Nov 23 - Nov 24

Other attractions near Buffalo Museum of Science

Johnnie B. Wiley Sport Pavilion

Catch an event at Johnnie B. Wiley Sport Pavilion during your trip to Buffalo. Experience the area's entertainment choices and great live music.

See properties

Top Buffalo Museum of Science Hotel Reviews

A grand staircase with ornate wood paneling and patterned carpet.

InnBuffalo off Elmwood

Elmwood Village

10/10 Excellent

Lerran

A spacious room with a large wooden table, several chairs, a sofa, and two chandeliers.

The Edward Hotel

Elmwood Village

10/10 Excellent

Dawn

The Mansion On Delaware Ave

Downtown Buffalo

10/10 Excellent

Evan

Curtiss Hotel, an Ascend Collection Hotel

Downtown Buffalo

10/10 Excellent

Eric

Buffalo Marriott at LECOM HARBORCENTER

Downtown Buffalo

10/10 Excellent

Anonymous traveler

Reikart House, Buffalo, a Tribute Portfolio Hotel

Buffalo

10/10 Excellent

We were so pleasantly surprised when we arrived at the hotel. We travel to Buffalo often, family and our daughter is in college there. We have stayed in many hotels in the area but none were as charming, beautifully designed, clean, and had a staff that was available for anything you needed. The lobby is like being in someones beautifully decorated living room. Our room was lovely with a very comfortable bed and a small living room wtth a pull out sofa. Thanks for the candy when we arrived...

Anonymous traveler

Residence Inn by Marriott Buffalo Downtown

Downtown Buffalo

10/10 Excellent

Anonymous traveler

The Westin Buffalo

Downtown Buffalo

10/10 Excellent

Jamal

Wyndham Garden Buffalo Downtown

Downtown Buffalo

10/10 Excellent

Kelly

Salvatores Grand Hotel

Buffalo

10/10 Excellent

This is a beautiful hotel. Our king suite was so very nice. Having a top rated restaurant right there was amazing and the breakfast next morning was delicious and well stocked. I can't wait to visit again and take some other family members. My husband said he would drive the 3 hours from where we live just to stay at the hotel and dine at Russells. That is saying something because he is not a traveler. The Christmas decorations were so very festive. We were there for a wake and memorial service...

Dawn

A lobby with teal armchairs, a round table, a flat-screen TV, and a stone wall with a fireplace.

The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

Buffalo

10/10 Excellent

Marc

Hampton Inn Buffalo - Amherst, NY

Buffalo

10/10 Excellent

Sarah

A multi-story hotel with a modern design, featuring a prominent entrance with a covered walkway and a courtyard.

Courtyard Buffalo Downtown / Canalside

Downtown Buffalo

10/10 Excellent

Staff was polite and helpful. Too many chemicals in pool burned my son's eyes. Will bring goggles next time. He didn't even open his eyes under water. But I understand the use of chemicals to keep it clean. Only negative thing was another young couple came down in the evening to use the pool and were very inappropriate in the pool area in front of my children. Not hotels fault. But we left earlier than we would have so they didn't have to see them doing what they were doing.

Theresa

A modern lounge area with blue upholstered chairs, a wooden rocking chair, a round table, and a patterned rug.

Hampton Inn Buffalo-Williamsville

Buffalo

10/10 Excellent

Erica

An outdoor patio with a fire pit, seating, and string lights.

Home2 Suites by Hilton Buffalo Airport / Galleria Mall

Buffalo

10/10 Excellent

Pam

A hotel with a prominent red sign, large windows, and a parking lot with multiple cars.

Hampton Inn & Suites Buffalo Downtown

Downtown Buffalo

10/10 Excellent

Vanessa

Best Western on the Avenue

Downtown Buffalo

10/10 Excellent

Marc J

Frequently Asked Questions

What's the area like around Buffalo Museum of Science?

Buffalo Museum of Science is located in a historic area of Buffalo known for its great live music scene. If you're looking for a convenient place to stay, check out the 14 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Buffalo Museum of Science?

Wyndham Garden Buffalo Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. It's located 1.2 mi (1.9 km) from Buffalo Museum of Science. Other good choices within 5 miles include Hyatt Regency Buffalo / Hotel and Conference Center and Buffalo Guesthouse.

How many hotels will I be able to find close to Buffalo Museum of Science?

Expedia has 14 hotels and other accommodations within a mile from Buffalo Museum of Science.

If I need to cancel the hotel reservation for my stay near Buffalo Museum of Science, will I receive a refund?

Yes, most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review the top deals on offer near Buffalo Museum of Science.

Where can I learn more about changing or cancelling my trip in the area near Buffalo Museum of Science?

For more information about picking new dates or cancelling your stay near Buffalo Museum of Science, go to https://www.expedia.com/service/.

What can I see and do near Buffalo Museum of Science?

Study the collections at Buffalo AKG Art Museum, Buffalo History Museum, or Buffalo and Erie County Naval and Military Park. Some landmarks that you won't want to miss include Buffalo Central Terminal, Statler Tower, and Richardson Olmsted Complex. You can watch performances at Kleinhans Music Hall, Town Ballroom, and Road Less Traveled Productions if you're interested in local theater.

Find hotels near Buffalo Museum of Science, Buffalo from ￥12,606

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Our top choices for Buffalo Museum of Science hotels

1. Buffalo Harmony House

2. Buffalo Guesthouse

3. The Mansion On Delaware Ave

4. Residence Inn by Marriott Buffalo Downtown

5. Wyndham Garden Buffalo Downtown

6. Best Western on the Avenue

7. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

8. Lenox Hotel and Suites

9. Aloft by Marriott Buffalo Downtown

10. Salvatores Grand Hotel

11. Reikart House, Buffalo, a Tribute Portfolio Hotel

12. Hampton Inn Buffalo - Amherst, NY

13. Buffalo Marriott at LECOM HARBORCENTER

14. Curtiss Hotel, an Ascend Collection Hotel

15. The Westin Buffalo

16. Hilton Garden Inn Buffalo Airport

17. Tru by Hilton Williamsville Buffalo Airport

18. The Richardson Hotel

19. Hyatt Place Buffalo/Amherst

20. Springhill Suites Buffalo Airport

Compare popular hotels close to Buffalo Museum of Science

Hotels recommended for families near Buffalo Museum of Science

Wyndham Garden Buffalo Downtown

Other attractions near Buffalo Museum of Science

Johnnie B. Wiley Sport Pavilion

Top Buffalo Museum of Science Hotel Reviews

InnBuffalo off Elmwood

10/10 Excellent

Frequently Asked Questions

What's the area like around Buffalo Museum of Science?

What's the best hotel to stay near Buffalo Museum of Science?

How many hotels will I be able to find close to Buffalo Museum of Science?

If I need to cancel the hotel reservation for my stay near Buffalo Museum of Science, will I receive a refund?

Where can I learn more about changing or cancelling my trip in the area near Buffalo Museum of Science?

What can I see and do near Buffalo Museum of Science?