Find 5 Star Hotels in Guanajuato from ￥19,392

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Guanajuato 5 Star Hotels

Tonight
Dec 26 - Dec 27
Tomorrow
Dec 27 - Dec 28
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Our top choices for Guanajuato 5-star hotels

Sauna, hot tub, steam room, body treatments, hot stone massages
Villa Maria Cristina

Villa Maria Cristina

Villa Maria Cristina
5.0 star property
De La Presa
9.4 out of 10, Exceptional, (391)
"Super clean great service very comfortable"
Canada
Benjamin
The price is ￥28,038
￥33,646 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Villa Maria Cristina
Panoramic Room, 2 Queen Beds, Poolside | Egyptian cotton sheets, premium bedding, down comforters
Casa Hala Santuario del Bienestar

Casa Hala Santuario del Bienestar

Casa Hala Santuario del Bienestar
5.0 star property
León
9.0 out of 10, Wonderful, (16)
"Was a pretty and convenient place. Excellent food too "
United States
Roberto
Casa Hala Santuario del Bienestar
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Guanajuato.
HS HOTSSON Hotel Leon

HS HOTSSON Hotel Leon

Blvd Adolfo Lopez Mateos #1102 Ote León GTO
The price is ￥17,903 per night from Jan 2 to Jan 3
￥17,903
￥21,484 total
Jan 2 - Jan 3, 2026
includes taxes & fees
9.2/10 Wonderful! (1,002 reviews)
Still don't see what you're looking for?
See all properties in Guanajuato.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Guanajuato

Colorful colonial buildings line the winding alleyways of this UNESCO city where you'll want to catch a callejoneada musical tour. Take the funicular up to the Pipila Monument for panoramic views, then explore the underground tunnels and Teatro Juárez's ornate façade.

See all hotels in Guanajuato

Top Guanajuato Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in Guanajuato?
Offering exceptional amenities and services, Expedia customers rate Villa Maria Cristina as one of the most popular 5-star hotels in Guanajuato. You'll be immersed in a world of luxury from the moment you step into the lobby.
How much does it cost to stay in a 5-star hotel in Guanajuato?
The amount you pay for a 5-star hotel in Guanajuato can vary based on when you prefer to travel and how long you plan to stay, among several factors. Use our price per night filter and other search tools to find the best rate on an indulgent stay.

  • Search for the lowest price per night from ￥19,392

What makes a hotel 5 stars in Guanajuato?
In Guanajuato, a hotel needs to provide a certain level of upscale conveniences to be rated 5 stars. These may include gourmet restaurants, saunas and spas, on-site gyms, luxury toiletries, premium bedding and more. What also sets 5-star hotels apart is their superior service. You can look forward to things like concierge services, in-room massages and nightly turn-down services. Some may also offer additional touches like a welcome gift.