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Top Adults Only Southeastern United States Hotels

Shoreline Island Resort - Exclusively Adult

14200 Gulf Boulevard Madeira Beach FL

4 hours drive from Walt Disney World® Resort

Book a stay at this beach aparthotel in Madeira Beach. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the helpful staff in our reviews. ...

9.2/10 Wonderful! (1,451 reviews)

The resort as a whole was very clean and well maintained. Staff was very friendly and helpful. We would staff here again in a heartbeat.

Reviewed on Feb 27, 2026

The Southernmost Inn - Adults Only

525 United Street Key West FL

11 hours drive from Walt Disney World® Resort

Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...

8.2/10 Very Good! (1,273 reviews)

Overhead fan was broken and kept us up all night, AC wasnt powerful enough by itself to cool the room down. Room had no curtains or shades, making it difficult to stay asleep past 8am. The building door kept slamming loudly, again making it difficult to sleep in.

Reviewed on Feb 27, 2026

Paradise Inn Key West - Adults Only

819 Simonton Street Key West FL

11 hours drive from Walt Disney World® Resort

Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, parking (surcharge), and daily housekeeping. Our guests praise the breakfast and ...

9.2/10 Wonderful! (1,003 reviews)

Location. Cleanliness. Staff was wonderful

Reviewed on Feb 27, 2026

See all 463,226 properties in Southeastern United States

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.