Photo by Quentin White

Find Boutique Hotels in Southwest, MS

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southwest Boutique Hotels

Our top choices for Southwest boutique hotels

Front of property
Monmouth Historic Inns and Gardens

Monmouth Historic Inns and Gardens

Monmouth Historic Inns and Gardens
4.0 star property
Natchez
9.4 out of 10, Exceptional, (639)
"Yes, yes. Dinner & breakfast were great! We enjoyed the grounds, the tour."
United States
Jack
The price is ￥22,437
￥28,497 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Monmouth Historic Inns and Gardens
Lobby
The Inn on Whitworth

The Inn on Whitworth

The Inn on Whitworth
3.5 star property
Brookhaven
10.0 out of 10, Exceptional, (233)
"The staff was friendly and professional. The variety of breakfast was very nice. Its location couldn’t be more ideal with the numerous restaurants that are all walking distance. Would recommend it to anyone "
United States
Nick
The Inn on Whitworth
Front of property
Devereaux Shields House

Devereaux Shields House

Devereaux Shields House
4.0 star property
Natchez
9.4 out of 10, Exceptional, (106)
"The menu was absolutely delicious! The staff was so friendly! Southern hospitality at its finest! "
United States
Kelly
The price is ￥24,581
￥27,508 total
includes taxes & fees
Dec 16 - Dec 17
Devereaux Shields House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southwest Hotel Reviews

Explore a world of travel with Expedia