San Antonio Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥45,448 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most. Learn more about San Antonio
La Merced Church which includes a city

Cusco Historic Center

7 out of top 10 points of interest in this area
4.5/5(904 area reviews)

Explore museums like Museo de Arte Precolombino and savor fusion and neo-Andean cuisine at local restaurants. Stroll through the artisan-filled San Blas neighborhood for a picturesque shopping experience.

Find hotels in Cusco Historic Center

San Antonio Hotel Deals

Union Hotel Cusco

Union Hotel Cusco

3.5 out of 5
Calle Union 189 Cusco Cusco
Fully refundableReserve now, pay when you stay
The price is ￥13,892 per night from Dec 16 to Dec 17
￥13,892
￥15,309 total
Dec 16 - Dec 17
9/10 Wonderful! (1,001 reviews)
Love this place, all the staff was very friendly, we love KIKI

Reviewed on Dec 9, 2025

Union Hotel Cusco
Sonesta Hotel Cusco

Sonesta Hotel Cusco

4 out of 5
Ave. El Sol 954 Cusco Cusco
Fully refundableReserve now, pay when you stay
The price is ￥20,894 per night from Dec 17 to Dec 18
￥20,894
￥22,983 total
Dec 17 - Dec 18
9.4/10 Exceptional! (1,003 reviews)
clean room . upgraded my room due to gold expedia status . good breakfast . great location . will stay there again .

Reviewed on Dec 13, 2025

Sonesta Hotel Cusco
Palacio del Inka, A Luxury Collection Hotel by Marriott

Palacio del Inka, A Luxury Collection Hotel by Marriott

5 out of 5
Plazoleta Santo Domingo No 259 Cusco Cusco
Fully refundableReserve now, pay when you stay
The price is ￥47,242 per night from Jan 4 to Jan 5
￥47,242
￥58,413 total
Jan 4 - Jan 5, 2026
9.4/10 Exceptional! (970 reviews)
Well located hotel. Proper 5 star. Breakfast excellent.

Reviewed on Nov 30, 2025

Palacio del Inka, A Luxury Collection Hotel by Marriott
See all 1,661 properties in San Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Antonio vacation package cost?
We make it simple to travel the world, with San Antonio packages starting from as little as . You'll have the flexibility to combine your preferred hotels, airlines and car rental. For the ultimate escape, why not add a few activities and tours to your travel itinerary?
How do I get a cheap travel package to San Antonio?
Crafting your own San Antonio vacation package with Expedia is one of the easiest ways to save. We offer more than 550 partner airlines and 1,000,000 hotel options spread across the globe. With such a fabulous range to pick from, you'll have no trouble pulling together your perfect getaway.
Where should I stay in San Antonio?
With fascinating attractions such as Regional Hospital of Cusco and National University of Saint Anthony the Abbot in Cuzco in this neighborhood, see if you can find a hotel near either of them. Real Plaza Cusco is another sight that visitors flock to.
What are the top hotels in San Antonio?
If it's comfort and convenience you're seeking, you can't go past Apart Las Margaritas Hotel. Spend your nights relaxing here and your days roaming around San Antonio's best sights.
How far in advance should I book my San Antonio vacation?
While not all air carriers advertise tickets early, you can normally start comparing international fares on Expedia up to a year in advance. This is the time you'll bag some incredible deals. If you've left things to the last minute, you might get lucky. Low prices sometimes emerge a few weeks before departure.
What does an Expedia San Antonio travel package include?
With Expedia, you can choose a combination of car rentals, hotels and flights to build your perfect San Antonio package. Once you've made your booking, you can add on fun stuff like sightseeing tours and activities. Remember, the more you bundle, the bigger the savings!
What should I know before booking a San Antonio travel package?
Bundling your bookings into a San Antonio vacation package is the easiest way to organize your trip. Not only that, you'll save big just for combining your hotels, flights and car rentals. Once you've booked, why not add on an activity or a tour?
Can I choose my airline with a San Antonio Expedia vacation package?
You can, and with more than 550 airlines to select from throughout the world, you're not short on choice. Look through the available options and see which airline best fits your budget and needs.
If I'm not able to travel, can I cancel my San Antonio vacation package?
Plans can change unexpectedly, so yes, you can. You may be able to cancel or change your San Antonio vacation package at no cost within 24 hours of booking. For older bookings, you can still cancel and rebook, but your car rental company, hotel or airline may charge a fee. Looking for more information? Check out our Customer Service Portal. We're here to help make sure your trip goes off without a hitch.

Discover the most popular places to visit in San Antonio

Plaza de Armas featuring a garden and a church or cathedral

Plaza de Armas

4.5/5(853 reviews)

Cusco’s busy main square has been the center of public life for centuries. Enjoy its spacious layout, ancient churches and restaurants.

Plaza de Armas
Cusco San Pedro Market showing markets and food as well as a small group of people

San Pedro Market

4.5/5(451 reviews)

Get caught up in the chaos of this intriguing attraction and enjoy a uniquely Andean experience.

San Pedro Market
Cusco Cathedral

Cusco Cathedral

4.5/5(551 reviews)

An imposing building constructed with stones from an Inca fortress is celebrated for its beautiful architecture and artwork that spans three centuries.

Cusco Cathedral

Things to do

Full-Day Excursion to Sacred Valley, Pisac and Ollantaytambo from Cusco

Full-Day Excursion to Sacred Valley, Pisac and Ollantaytambo from Cusco

￥7,540
per adult
Full-Day Excursion to Sacred Valley, Pisac and Ollantaytambo from Cusco
Cusco City Tour Four Ruins Half-Day Tour

Cusco City Tour Four Ruins in Half-Day

￥6,296
per adult
100% of travellers recommend
Cusco City Tour Four Ruins in Half-Day
Cusco: Rainbow Mountain Day Trip and Red Valley

Cusco: Rainbow Mountain and Red Valley Day Trip with Meals

￥3,683
per adult
96% of travellers recommend
Cusco: Rainbow Mountain and Red Valley Day Trip with Meals
See all activities in Cusco
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.