Palmyra, MO Vacation Homes

A river with a dam, surrounded by greenery and a clear sky.

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Our top choices for Palmyra vacation homes

Sunlit Studio on Historic Main Street

Palmyra

Valerie V.

￥33,395 total

includes taxes & fees

Jul 26 - Jul 27

Peaceful, Country Cottage with Open Floor Plan

Quincy

Terry H.

￥40,092 total

includes taxes & fees

Jul 26 - Jul 27

Vibey home a few blocks from downtown Hannibal

Hannibal

Shaun P.

￥45,249 total

includes taxes & fees

Jul 19 - Jul 20

Coffee/tea maker, fridge, microwave, oven

Aunt Lele's Cozy Cottage

Quincy

Jessica F.

￥31,460 total

includes taxes & fees

Aug 9 - Aug 10

Serene & Modern Oasis - Newly Built, Attached Garage, Centrally Located

Quincy

Marsha

￥34,245 total

includes taxes & fees

Aug 9 - Aug 10

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

Hannibal

Charlene

￥30,417 total

includes taxes & fees

Aug 18 - Aug 19

The John Sydney House - Family and Pet Friendly Historic Home Downtown

Hannibal

Brian H.

￥38,174 total

includes taxes & fees

Jul 20 - Jul 21

Shouse Near Mark Twain Lake!

Monroe City

Christina H.

￥50,687 total

includes taxes & fees

Aug 12 - Aug 13

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Top Palmyra Hotel Reviews

Super 8 by Wyndham Hannibal

10/10 Excellent

"Reasonably priced and convenient to all of the local attractions. Comfortable beds."

Sleep Inn & Suites Hannibal West

10/10 Excellent

"We would absolutely stay here again. Hotel was very clean. The lady who checked us in was amazing! Hotels.com customer service booked us the wrong room, even though I asked multiple if it was an accessible room. The lady who checked us in ended up upgrading us to an accessible suite at no extra charge because there were no other accessible rooms. Every time we saw her in the lobby she checked on us to make sure the room was ok and we were enjoying our stay. Breakfast was great."

Heritage Hotel Quincy

10/10 Excellent

"The hotel had been renovated in late 2024, so the entire property is clean and well maintained. The staff were extremely helpful and attentive! The room was very quiet & spacious. There were also plenty of electrical plugs, many with USB-A connectors. The bed was very comfortable (a make or break for me) and the bathroom super clean & functional, with unlimited hot water (also critical). The breakfast was pretty bare bones, but filling. A waffle maker, fresh fruit, & hot/cold cereals would be a nice addition, but the price of the room was so inexpensive for the quality that the owners might lose money if they added much more to the breakfast offerings. I really enjoyed the hotel’s location in the old town, overlooking the Mississippi River and bridge and just steps from Washington Park (location of the Lincoln-Douglass Senatorial campaign debate of 1858). Buildings in the old town are being renovated, and I hope it becomes a real destination that encourages visitors to stay for a few days. Right now, most of the shopping area is to the East, with blocks of national chain stores. Pretty much as cookie cutter as it gets. I would love to be able to eat at some unique restaurants, shop at local, one-of-a-kind stores, and enjoy some live music, art galleries, etc. This hotel is a real gem, and we’ll definitely be back!"

Quality Inn & Suites Hannibal West

10/10 Excellent

"Stayed here multiple times. Rooms are big compared to other hotel rooms. A lil dated and only interaction with staff was while checking in. Has a bar but I believe it’s only open on weekends. Pool deck is very nice but in need of a few repairs. Overall, it’s always been an enjoyable stay which is why we always choose this hotel while in the area. Breakfast provided as well."

Lighthouse Inn & Suites

8/10 Good

"Hotels.com [and other third party sites] are not booking correctly with this hotel. I don't believe that the room I rented was worth what I paid. When we got there it was 8pm and we had read that check in is until 9pm. The office was closed with a sign on the door: "text/call us for emergencies. And third party sites are not being communicated with them well." I had to call to be texted a code and room to enter on the spot, thankfully. The room was small for 2 queen beds. Nice, new fridge. Maybe 10 parking spots in the lot. It was clear the rooms had been recently renovated because their were codes still visible on the sheets and bathroon door and the freezer still had the instruction manual inside. The TV kept being changed by [assuming] another room because it kept going back to the same channel/show, We watched cautiously with the idea that our remote might change another TV, too. Also, there was not a light switch for lights in the bed area, and they had to be turned on manually. The pool was great but we only used it once for a short time. There was consctruction on the street in front which made the walk into town a little wonky, but fine. We did experience a fire alarm around midnight on the first night and stayed in car until given "clear"- The staff never followed up about it. So most likely will not stay there again with those prices. [We were also under the assumption that there was a hot tub in the room - not true]"

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Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Palmyra vacation homes

Sunlit Studio on Historic Main Street

Peaceful, Country Cottage with Open Floor Plan

Vibey home a few blocks from downtown Hannibal

Aunt Lele's Cozy Cottage

Serene & Modern Oasis - Newly Built, Attached Garage, Centrally Located

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

The John Sydney House - Family and Pet Friendly Historic Home Downtown

Shouse Near Mark Twain Lake!

Gorgeous Victorian with Seasonal Pool , sleeps 8, pet friendly close to downtown

Charming 3-bedroom house, 2-car garage, and pickleball court

Find vacation rentals that suit your style

Top Palmyra Hotel Reviews

Super 8 by Wyndham Hannibal

Sleep Inn & Suites Hannibal West

Heritage Hotel Quincy

Days Inn by Wyndham Hannibal

Motel 6 Hannibal, MO

Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

Oak Hill Inn & Suites

Quality Inn & Suites Hannibal West

Lighthouse Inn & Suites

Find out more about Palmyra

Palmyra Vacation Homes information

Explore a world of travel with Expedia

Search Vacation Homes in Palmyra

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Palmyra vacation homes

Sunlit Studio on Historic Main Street

Peaceful, Country Cottage with Open Floor Plan

Vibey home a few blocks from downtown Hannibal

Aunt Lele's Cozy Cottage

Serene & Modern Oasis - Newly Built, Attached Garage, Centrally Located

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

The John Sydney House - Family and Pet Friendly Historic Home Downtown

Shouse Near Mark Twain Lake!

Gorgeous Victorian with Seasonal Pool , sleeps 8, pet friendly close to downtown

Charming 3-bedroom house, 2-car garage, and pickleball court

Find vacation rentals that suit your style

Top Palmyra Hotel Reviews

Super 8 by Wyndham Hannibal

Find out more about Palmyra

Palmyra Vacation Homes information

Explore a world of travel with Expedia