The Best Hotels Closest to Louisville Science Center in Louisville for 2026

The entrance to the Kentucky Science Center with a large circular structure in the foreground.

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Our top choices for Louisville Science Center hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

A covered outdoor seating area with wicker furniture and a wooden railing.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

1. Louisville Bourbon Inn

Old Louisville, 2.9 km from Louisville Science Center

Roy

￥44,105

￥51,193 total

includes taxes & fees

Oct 19 - Oct 20

A wooden staircase with a balustrade leading to a landing.

A brick building with a covered porch, columns, and potted plants.

A dining area with brick walls, wooden shelves, and tables set for a meal.

A two-story brick building with a white porch and a sign reading "Hotel".

2. Market Street Inn

2.1 km from Louisville Science Center

Holly

￥34,956

￥39,501 total

includes taxes & fees

Oct 18 - Oct 19

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

3. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.2 km from Louisville Science Center

Kelly

￥13,184

￥15,513 total

includes taxes & fees

Oct 29 - Oct 30

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

4. Hotel Distil, Autograph Collection

Downtown Louisville, 0.9 km from Louisville Science Center

Heather

￥37,421

￥44,029 total

includes taxes & fees

Oct 29 - Oct 30

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern lobby with a fireplace, seating area, and a reception desk.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

5. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from Louisville Science Center

Gordon

￥16,123

￥18,971 total

includes taxes & fees

Oct 29 - Oct 30

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

6. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from Louisville Science Center

Casey

￥22,616

￥26,249 total

includes taxes & fees

Nov 4 - Nov 5

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

7. The Brown Hotel

Downtown Louisville, 1.2 km from Louisville Science Center

John

￥19,808

￥23,307 total

includes taxes & fees

Oct 29 - Oct 30

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A lobby with a marble floor, a reception desk, and a large chandelier.

8. Omni Louisville Hotel

Downtown Louisville, 0.8 km from Louisville Science Center

Samantha

￥19,857

￥23,364 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

9. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2.1 km from Louisville Science Center

Addison

￥19,346

￥22,763 total

includes taxes & fees

Oct 25 - Oct 26

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

A modern restaurant interior with a staircase, round tables, and a brick wall.

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

10. The Grady

Downtown Louisville, 0.2 km from Louisville Science Center

Donna

￥24,621

￥28,970 total

includes taxes & fees

Nov 15 - Nov 16

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

11. Stellar Suites

East Market District, 2.2 km from Louisville Science Center

Kevin

￥18,281

￥29,476 total

includes taxes & fees

Oct 18 - Oct 19

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

12. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from Louisville Science Center

Matt

￥24,090

￥29,137 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

13. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from Louisville Science Center

Cameron

￥28,388

￥33,402 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor seating area with wicker furniture and a fire pit.

A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.

A modern lounge area with seating, tables, and a view of the city through large windows.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

14. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from Louisville Science Center

Derek

￥15,359

￥18,072 total

includes taxes & fees

Nov 8 - Nov 9

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

15. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

Dolores

￥14,630

￥17,213 total

includes taxes & fees

Nov 8 - Nov 9

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

16. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

Alicia

￥13,184

￥15,512 total

includes taxes & fees

Nov 15 - Nov 16

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A bedroom with a bed, a chair, a TV, and a window with curtains.

A brightly lit grocery store with yellow shelving and a central checkout counter.

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

17. Hotel Genevieve part of JdV by Hyatt

East Market District, 2.1 km from Louisville Science Center

Tyler

￥21,376

￥25,151 total

includes taxes & fees

Oct 25 - Oct 26

A covered patio with a stone wall, a glass table, and a bench.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

A grand room with a fireplace, a staircase, and a chandelier.

18. Central Park Bed & Breakfast

Old Louisville, 3 km from Louisville Science Center

Nicole

￥24,026

￥27,887 total

includes taxes & fees

Oct 25 - Oct 26

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

19. AC Hotel Louisville Downtown

East Market District, 2.1 km from Louisville Science Center

Jen

￥22,621

￥26,617 total

includes taxes & fees

Oct 25 - Oct 26

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

A balcony with a view of a river, a bridge, and a cityscape.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

20. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from Louisville Science Center

Mark

￥22,944

￥26,995 total

includes taxes & fees

Oct 27 - Oct 28

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Compare popular hotels close to Louisville Science Center

Property	Star rating	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
Market Street Inn	9.8 Exceptional 125 reviews	View
Homewood Suites by Hilton Louisville Downtown, KY	9.4 Exceptional 1,000 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 510 reviews	View
Cambria Hotel Louisville Downtown-Whiskey Row	9.4 Exceptional 1,008 reviews	View

Top Louisville Science Center Hotel Reviews

The Grady

10/10 Excellent

"10/10. Rad decor. Great walkable spot. Friendly staff. Easy check in and check out. They open the front door for you as you come and go. Very great experience"

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent

"Location was perfect and staff was very friendly."

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"Gorgeous property. Will stay here again!"

Embassy Suites Louisville Downtown

10/10 Excellent

"Location is great. Staff is helpful. It’s clean and comfortable. Great breakfast every morning too. A few bottles of water in the room would have been nice but overall very happy with our stay and would come back."

Holiday Inn Express & Suites Louisville Downtown by IHG

8/10 Good

"Breakfast was great. Wonderful options and perfect temperature. The hotel is convenient to whiskey row and the Louisville Slugger museum."

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"Attending a conference that was being held at a separate location, I appreciated the location, attention, safety, and accessibility to the city that was provided."

21c Museum Hotel Louisville

10/10 Excellent

"This was our second stay here and will stay again when in town. Very cool place if you like art. Great service. Nice room but nothing really special about it. Super convenient location downtown on Main Street, walking distance to many attractions and distilleries. Very good on-site restaurant/bar."

Louisville Marriott Downtown

8/10 Good

"room was very clean but the there were additional blankets provided"

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent

"Very comfortable place to stay and all the team was very nice!"

Other attractions near Louisville Science Center

A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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The Frazier History Museum with red doors and a tree in front.

Frazier International History Museum

9.4/10 (10 reviews)

Get to know Louisville with a visit to this esteemed museum. It’s a great spot for social interaction as well.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Louisville Glassworks

You can spend an afternoon studying the exhibits at Louisville Glassworks in Louisville. Experience the area's lively festivals or attend a sporting event.

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Frequently asked questions

What's the area like around Louisville Science Center?

Louisville Science Center is located in an area of Louisville known for its beautiful river views, sporting events, and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Louisville Science Center?

Adjacent to Louisville Science Center, Holiday Inn Express & Suites Louisville Downtown by IHG is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.

How many hotels can I expect to find close to Louisville Science Center?

Expedia has 292 hotels and other accommodations within a mile from Louisville Science Center.

If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to review the best deals near Louisville Science Center.

Where can I learn more about changing or cancelling my trip in the area near Louisville Science Center?

For more details about picking new dates or cancelling your stay near Louisville Science Center, click here.

What can I see and do near Louisville Science Center?

21c Museum Hotel, Louisville Slugger Museum, and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can catch a show at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall.

Find hotels near Louisville Science Center, Louisville from ￥15,512

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Louisville Science Center hotels

1. Louisville Bourbon Inn

2. Market Street Inn

3. Homewood Suites by Hilton Louisville Downtown, KY

4. Hotel Distil, Autograph Collection

5. Cambria Hotel Louisville Downtown-Whiskey Row

6. DuPont Mansion Bed & Breakfast

7. The Brown Hotel

8. Omni Louisville Hotel

9. Tempo By Hilton Louisville Downtown Nulu

10. The Grady

11. Stellar Suites

12. 21c Museum Hotel Louisville

13. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

14. Towneplace Suites By Marriott Louisville Downtown

15. Aloft by Marriott Louisville Downtown

16. Moxy Louisville Downtown

17. Hotel Genevieve part of JdV by Hyatt

18. Central Park Bed & Breakfast

19. AC Hotel Louisville Downtown

20. Galt House Hotel Trademark Collection by Wyndham

Compare popular hotels close to Louisville Science Center

Top Louisville Science Center Hotel Reviews

The Grady

Cambria Hotel Louisville Downtown-Whiskey Row

Galt House Hotel Trademark Collection by Wyndham

Embassy Suites Louisville Downtown

Holiday Inn Express & Suites Louisville Downtown by IHG

Towneplace Suites By Marriott Louisville Downtown

21c Museum Hotel Louisville

Louisville Marriott Downtown

Homewood Suites by Hilton Louisville Downtown, KY

Other attractions near Louisville Science Center

Louisville Slugger Museum

Muhammad Ali Center

Frazier International History Museum

Kentucky Center for the Performing Arts

Kentucky Museum of Art and Craft

Golden Statue of David

SAR Genealogical Research Library: NSSAR Library

Louisville Glassworks

Frequently asked questions