The Best Hotels Closest to Louisville Science Center in Louisville for 2026

The entrance to the Kentucky Science Center with a large circular structure in the foreground.

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Our top choices for Louisville Science Center hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

1. Louisville Bourbon Inn

Old Louisville, 2.9 km from Louisville Science Center

Roy

￥44,665

￥51,841 total

includes taxes & fees

Aug 31 - Sep 1

A wooden staircase with a balustrade leading to a landing.

A dining area with brick walls, wooden shelves, and tables set for a meal.

A brick building with a covered porch, columns, and potted plants.

A bedroom with a bed, a dresser, a television, and a desk with a lamp.

2. Market Street Inn

2.1 km from Louisville Science Center

Holly

￥26,693

￥30,162 total

includes taxes & fees

Aug 31 - Sep 1

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

3. Hotel Distil, Autograph Collection

Downtown Louisville, 0.9 km from Louisville Science Center

Jasmine

￥31,162

￥36,664 total

includes taxes & fees

Sep 6 - Sep 7

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

4. Stellar Suites

East Market District, 2.2 km from Louisville Science Center

Brad

￥14,859

￥25,609 total

includes taxes & fees

Sep 1 - Sep 2

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

5. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from Louisville Science Center

Casey

￥22,368

￥25,964 total

includes taxes & fees

Aug 31 - Sep 1

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

6. The Brown Hotel

Downtown Louisville, 1.2 km from Louisville Science Center

Rachel

￥23,893

￥28,113 total

includes taxes & fees

Sep 4 - Sep 5

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A swimming pool with lounge chairs and a view of the city.

7. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.2 km from Louisville Science Center

Jon

￥18,247

￥21,469 total

includes taxes & fees

Sep 6 - Sep 7

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

8. The Grady

Downtown Louisville, 0.2 km from Louisville Science Center

Conswaila

￥26,295

￥30,939 total

includes taxes & fees

Aug 31 - Sep 1

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A modern hotel room with a large bed, a city view, and a unique headboard design.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from Louisville Science Center

Breeana

￥27,436

￥32,281 total

includes taxes & fees

Sep 7 - Sep 8

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

10. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from Louisville Science Center

Candice

￥28,656

￥34,518 total

includes taxes & fees

Sep 3 - Sep 4

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

11. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2.1 km from Louisville Science Center

Maria

￥18,903

￥22,242 total

includes taxes & fees

Sep 3 - Sep 4

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A modern interior with a fireplace, bookshelves, and seating areas.

12. Omni Louisville Hotel

Downtown Louisville, 0.8 km from Louisville Science Center

Kara

￥31,890

￥37,520 total

includes taxes & fees

Sep 2 - Sep 3

An outdoor seating area with wicker furniture and a fire pit.

A modern lounge area with seating, tables, and a view of the city through large windows.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

13. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from Louisville Science Center

￥15,512

￥18,251 total

includes taxes & fees

Sep 6 - Sep 7

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern lobby with a fireplace, seating area, and a reception desk.

14. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from Louisville Science Center

Riley

￥16,321

￥19,203 total

includes taxes & fees

Sep 7 - Sep 8

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

15. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

Nina

￥16,649

￥19,590 total

includes taxes & fees

Sep 6 - Sep 7

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

16. AC Hotel Louisville Downtown

East Market District, 2.1 km from Louisville Science Center

David

￥19,473

￥22,912 total

includes taxes & fees

Sep 4 - Sep 5

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern coffee shop interior with a central island, wooden counter, and large windows.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

17. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

Angela

￥17,141

￥20,169 total

includes taxes & fees

Sep 6 - Sep 7

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

A bedroom with a bed, a chair, a TV, and a window with curtains.

A yellow coffee shop counter with a menu board above, displaying various coffee and food items.

18. Hotel Genevieve part of JdV by Hyatt

East Market District, 2.1 km from Louisville Science Center

Rebekah

￥21,612

￥25,429 total

includes taxes & fees

Sep 6 - Sep 7

A covered patio with a stone wall, a glass table, and a bench.

A garden pathway with a lantern, potted plants, and a white fence.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

19. Central Park Bed & Breakfast

Old Louisville, 3 km from Louisville Science Center

Angie

￥18,939

￥21,984 total

includes taxes & fees

Aug 31 - Sep 1

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

A balcony with a view of a river, a bridge, and a cityscape.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

20. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from Louisville Science Center

Jacob

￥22,892

￥26,935 total

includes taxes & fees

Sep 8 - Sep 9

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Compare popular hotels close to Louisville Science Center

Property	Star rating	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
Market Street Inn	9.8 Exceptional 124 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 499 reviews	View
Stellar Suites	9.6 Exceptional 147 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 146 reviews	View

Top Louisville Science Center Hotel Reviews

Radisson Hotel Louisville North

10/10 Excellent

"Only issue i had was it didn't tell me I had to pay for breakfast. 10.99 for the buffet with 7 people.. I thought it was included. Definitely should be added to the page so people will know. But other then that the stay was wonderful."

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent

"This was a very pleasant stay. The room was amazing and the staff were very professional and courteous."

Aloft by Marriott Louisville Downtown

10/10 Excellent

"We had a good stay. Nice and clean. We’ll stay again"

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"The location was awesome and the room was huge but it lacked a microwave. There are so many great restaurants nearby and we had plenty of leftovers but no was to reheat them."

Holiday Inn Louisville Downtown by IHG

10/10 Excellent

"Excellent location, great staff and rooms"

Hilton Garden Inn Louisville Downtown

10/10 Excellent

"Great, nice, clean hotel & close to the Louisville Palace, only a 2 minute walk."

SpringHill Suites by Marriott Louisville Downtown

8/10 Good

"the view as I look out over the city ar night"

Moxy Louisville Downtown

10/10 Excellent

"Always a great spot to stay in Louisville!"

The Grady

8/10 Good

"Front desk staff was very friendly and helpful. Facility was super clean and well kept. Room was clean, well appointed & decorated. Cleaning staff had left the AC on full tilt, so my wife loved that! Valet was a little slow, but I believe that was an outside contractor and they seemed understaffed, so not really the fault of the hotel. The only reason I knocked off one star was because of an overnight ruckus outside our room that unfortunately led to the police coming by the next morning and knocking on doors. Not sure if the hotel could have done anything at all to avoid the issue, but it was a detraction from our experience nonetheless."

Other attractions near Louisville Science Center

A wall of wooden baseball bats organized by size and weight.

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A vintage car and a wooden barrel with a sign reading "Spirits of the Bluegrass Prohibition Kentucky" on a brick wall.

Frazier International History Museum

9.4/10 (10 reviews)

Get to know Louisville with a visit to this esteemed museum. It’s a great spot for social interaction as well.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its great live music.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Louisville Glassworks

You can spend an afternoon studying the exhibits at Louisville Glassworks in Louisville. Experience the area's acclaimed theater scene or attend a sporting event.

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Frequently asked questions

What's the area like around Louisville Science Center?

Louisville Science Center is located in an area of Louisville known for its beautiful river views, sporting events, and great live music scene. If you're looking for a convenient place to stay, check out the 293 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Louisville Science Center?

Adjacent to Louisville Science Center, Holiday Inn Express & Suites Louisville Downtown by IHG is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.

How many hotels can I expect to find close to Louisville Science Center?

Expedia has 293 hotels and other accommodations within a mile from Louisville Science Center.

If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to review the best deals near Louisville Science Center.

Where can I learn more about changing or cancelling my trip in the area near Louisville Science Center?

For more details about picking new dates or cancelling your stay near Louisville Science Center, click here.

What can I see and do near Louisville Science Center?

21c Museum Hotel, Louisville Slugger Museum, and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can catch a show at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall.

Find hotels near Louisville Science Center, Louisville from ￥18,251

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Louisville Science Center hotels

1. Louisville Bourbon Inn

2. Market Street Inn

3. Hotel Distil, Autograph Collection

4. Stellar Suites

5. DuPont Mansion Bed & Breakfast

6. The Brown Hotel

7. Homewood Suites by Hilton Louisville Downtown, KY

8. The Grady

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

10. 21c Museum Hotel Louisville

11. Tempo By Hilton Louisville Downtown Nulu

12. Omni Louisville Hotel

13. Towneplace Suites By Marriott Louisville Downtown

14. Cambria Hotel Louisville Downtown-Whiskey Row

15. Moxy Louisville Downtown

16. AC Hotel Louisville Downtown

17. Aloft by Marriott Louisville Downtown

18. Hotel Genevieve part of JdV by Hyatt

19. Central Park Bed & Breakfast

20. Galt House Hotel Trademark Collection by Wyndham

Compare popular hotels close to Louisville Science Center

Top Louisville Science Center Hotel Reviews

Radisson Hotel Louisville North

Homewood Suites by Hilton Louisville Downtown, KY

Aloft by Marriott Louisville Downtown

Galt House Hotel Trademark Collection by Wyndham

Holiday Inn Louisville Downtown by IHG

Hilton Garden Inn Louisville Downtown

SpringHill Suites by Marriott Louisville Downtown

Moxy Louisville Downtown

The Grady

Other attractions near Louisville Science Center

Louisville Slugger Museum

Muhammad Ali Center

Frazier International History Museum

Kentucky Center for the Performing Arts

Kentucky Museum of Art and Craft

Golden Statue of David

SAR Genealogical Research Library: NSSAR Library

Louisville Glassworks

Frequently asked questions