Lake City Vacation Rentals

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Check prices for these dates

In two weeks
Dec 26 - Dec 28
In two months
Feb 6 - Feb 8
In three months
Mar 6 - Mar 8
In four months
Apr 3 - Apr 5

Our top choices for Lake City vacation rentals

Interior
Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.
Florence
9.8 out of 10, Exceptional, (42)
"The house was beautiful. We would stay there again!!"
United States
Stephanie L.
The price is ￥20,894
￥36,315 total
includes taxes & fees
Dec 14 - Dec 15
Walking distance from one of South Carolina's top Medical centers.
1 bedroom, iron/ironing board, WiFi, bed sheets
Charming 1-bedroom cabin in welcoming Florence with AC and heating

Charming 1-bedroom cabin in welcoming Florence with AC and heating

Charming 1-bedroom cabin in welcoming Florence with AC and heating
2.0 star property
Florence
Charming 1-bedroom cabin in welcoming Florence with AC and heating
Fridge, microwave, oven, stovetop
Creekside Country Cottage- minutes away from I-95

Creekside Country Cottage- minutes away from I-95

Creekside Country Cottage- minutes away from I-95
Manning
10.0 out of 10, Exceptional, (9)
"Great place beautiful and the dogs loved it"
United States
Jennifer T.
The price is ￥35,057
￥68,142 total
includes taxes & fees
Dec 15 - Dec 16
Creekside Country Cottage- minutes away from I-95
Interior
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Florence
10.0 out of 10, Exceptional, (35)
"Perfect stay for our family wedding weekend!! Home was immaculate and a perfect layout! Host has thought of everything you may need during your stay from extra linens to a fully stocked kitchen. Awesome location and super nice neighborhood!"
United States
Cathy D.
The price is ￥38,641
￥49,211 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lake City Hotel Reviews

Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

10/10 Excellent
"Everything was good except tv issues "
Jalik 2-night trip
Posted 3 days ago
Days Inn by Wyndham Florence Near Civic Center

Find out more about Lake City

Search for holiday rentals in Lake City on Expedia! You can easily find your home rentals, villas, holiday apartments in Lake City using one of the methods below:

  • View our selection of featured holiday rentals in Lake City
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Look no further and take a look at our great range of rental properties in Lake City!

Frequently asked questions

Can I find a vacation rental in Lake City?

Yes, we offer vacation rentals in Lake City near Moore Farms Botanical Garden, or you can choose a secluded option if you want a relaxing stay. Visitors to Lake City speak positively about the lakeside and restaurants in this destination. Make sure you have time to check out the shopping and parks during your trip.

What are some of the best vacation rentals that Lake City has to offer?

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's: This vacation home rental outside of Lake City offers a fireplace, a patio, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the garden in this rental home to help you unwind.

What can I see and do in Lake City?

Lions Park and Ronald E. McNair Life History Center are a couple of lovely local spots to get outside and enjoy nature. The Country Club at Lake City and Lynches Lake Historical Society are other places to visit while you're in town.

What are vacation rentals like in Lake City?

Vacation rentals are private properties you can stay in for a couple days or more in Lake City. Vacation rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a clean environment, vacation rentals can offer a sense of seclusion away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for family trips or small group gatherings.