La Serena Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for La Serena vacation rentals

A row of single-story houses with a well-maintained lawn and garden beds.

1. Apart Hotel y Cabañas Vegasur

Apart Hotel y Cabañas Vegasur
3.0 star property
La Serena
8.6 out of 10, Excellent, (97 reviews)
"Clean place, friendly staff, beach near, kitchen, and walking distance to nice restaurants and to enjoy the sunset and sunrise. Great location"
United States
Sandra
The price is ￥7,263
￥7,263 total
Nov 11 - Nov 12
Apart Hotel y Cabañas Vegasur
A modern house with a deck, outdoor seating, and a well-maintained lawn.

2. Cabañas MarSerena

Cabañas MarSerena
3.5 star property
La Serena
9.0 out of 10, Wonderful, (53 reviews)
"very nice place to stay close to the beach, reasonably price and everybody there was very very pleasant"
United States
JOHN
The price is ￥8,842
￥8,842 total
Nov 21 - Nov 22
Cabañas MarSerena
A cluster of geodesic dome structures with windows, a swimming pool, and outdoor seating.

3. Domos Dream hotel cabañas

Domos Dream hotel cabañas
2.0 star property
La Serena
8.6 out of 10, Excellent, (4 reviews)
"It was far away."
Mexico
Sergio
The price is ￥8,601
￥8,601 total
Nov 10 - Nov 11
Domos Dream hotel cabañas
A round glass table with a bottle, glasses, and flower petals on a balcony overlooking a beach and cityscape.

4. La Choza VIP Turquesa en La Serena

La Choza VIP Turquesa en La Serena
3.0 star property
Coquimbo
7.8 out of 10, Good, (12 reviews)
"The apartment was very good for my needs and close to the conference centre. Safe, clean, well appointed. Yanitza was a big help and responsive to WhatsApp messages."
Canada
Andrew
The price is ￥12,551
￥12,551 total
Nov 19 - Nov 20
La Choza VIP Turquesa en La Serena
A room with a large window overlooking a coastal area, a chair, and a small table.

5. Vista al mar - Estudio para 3 personas

Vista al mar - Estudio para 3 personas
2.0 star property
Coquimbo
The price is ￥6,999
￥6,999 total
Nov 11 - Nov 12
Vista al mar - Estudio para 3 personas
A swimming pool with clear water, surrounded by palm trees and a gazebo.

6. Apart Hotel Gran Pacifico

Apart Hotel Gran Pacifico
3.0 star property
La Serena
8.6 out of 10, Excellent, (39 reviews)
"En gral buena eleccion"
Argentina
Javier
The price is ￥16,851
￥16,851 total
Dec 6 - Dec 7
Apart Hotel Gran Pacifico
An outdoor seating area with a wooden deck, a cushioned sofa, and potted plants.

7. Cabañas Pinamar

Cabañas Pinamar
3.0 star property
Elqui
The price is ￥8,775
￥8,775 total
Nov 10 - Nov 11
Cabañas Pinamar
A table with a fruit basket and a plate with cutlery, overlooking a coastal view with buildings and greenery.

8. 2nd Floor WiFi La Serena Beach & Casino!

2nd Floor WiFi La Serena Beach & Casino!
Coquimbo
10.0 out of 10, Exceptional, (1 review)
"Excelente departamento, ubicación y comodidad, muchas gracias Yanitza por todo!!! Esperamos volver pronto!"
United States
Daniela
The price is ￥13,154
￥21,395 total
Nov 10 - Nov 11
2nd Floor WiFi La Serena Beach & Casino!
Room

9. ELDEPTO LA SERENA

ELDEPTO LA SERENA
3.0 star property
Coquimbo
8.0 out of 10, Very good, (2 reviews)
"Boa localização de fácil acesso, tranquilidade e bom atendimento"
Brazil
Ricardo Horacio
The price is ￥7,417
￥7,417 total
Nov 10 - Nov 11
ELDEPTO LA SERENA
A spacious room with a dining table, chairs, a hanging light fixture, and a wall adorned with decorative plates.

10. New Listing

New Listing
Coquimbo
The price is ￥10,649
￥14,615 total
Nov 10 - Nov 11
New Listing
A playground with a slide and climbing structures, a covered seating area, and a view of the sea.

11. Beautiful Apartment on the Beach

Beautiful Apartment on the Beach
Coquimbo
10.0 out of 10, Exceptional, (1 review)
"The property is right on the beach with a huge pool. The parking is gated and secure. There is a walking bridge right beside the building to let you cross the busy highway so you can access restaurants. The host was very accommodating and helpful. The carpets in the hallway were really stained, but that was our only complaint. We had a good stay in a lovely location."
Canada
Layla
The price is ￥10,331
￥14,237 total
Nov 10 - Nov 11
Beautiful Apartment on the Beach
A balcony with a view of the ocean and buildings.

12. "Nicoland" Playa, piscina, La Serena

"Nicoland" Playa, piscina, La Serena
La Serena
10.0 out of 10, Exceptional, (1 review)
"Hermoso departamento,muy bien amoblado, no le falta nada. Excelente ubicación. Queremos destacar la atención de la anfitriona Yanitza, quien siempre estuvo atenta a todas nuestras necesidades y consultas. De seguro volveremos!"
United States
Daniela
The price is ￥12,678
￥20,919 total
Nov 10 - Nov 11
"Nicoland" Playa, piscina, La Serena
A residential area with a swimming pool, a well-maintained garden, and tall apartment buildings in the background.

13. Comfortable apartment in Coquimbo with parking

Comfortable apartment in Coquimbo with parking
Coquimbo
The price is ￥7,064
￥9,007 total
Nov 10 - Nov 11
Comfortable apartment in Coquimbo with parking
A modern lobby with a brick wall, two sofas, wooden furniture, and a view of the outside.

14. Beach, breezes, and the sea—a beautiful and comfortable apartment in an exceptional location.

Beach, breezes, and the sea—a beautiful and comfortable apartment in an exceptional location.
Coquimbo
The price is ￥7,449
￥14,728 total
Nov 10 - Nov 11
Beach, breezes, and the sea—a beautiful and comfortable apartment in an exceptional location.
A room with a sofa, a small table, a TV mounted on a sliding door, and framed pictures on the wall.

15. Accommodations Near the Ocean, Downtown, and the Valley; Private Room + Free Parking

Accommodations Near the Ocean, Downtown, and the Valley; Private Room + Free Parking
La Serena
The price is ￥5,705
￥20,285 total
Nov 10 - Nov 11
Accommodations Near the Ocean, Downtown, and the Valley; Private Room + Free Parking
A high-rise residential building with multiple balconies, a parking area, and a view of the sea.

16. Apartment across from La Herradura Beach—ideal for families

Apartment across from La Herradura Beach—ideal for families
Coquimbo
The price is ￥11,920
￥27,284 total
Nov 10 - Nov 11
Apartment across from La Herradura Beach—ideal for families
A kitchen with a coffee machine, a water dispenser, and a container labeled "Flower Garden" on the counter.

17. Trabajo y Relax VIP en La Serena

Trabajo y Relax VIP en La Serena
La Serena
The price is ￥9,509
￥12,996 total
Nov 16 - Nov 17
Trabajo y Relax VIP en La Serena
A multi-story residential building with balconies, a gated courtyard, and a street lamp.

18. Apt 107D Jardines del Pacifico IV

Apt 107D Jardines del Pacifico IV
La Serena
The price is ￥8,742
￥10,685 total
Nov 10 - Nov 11
Apt 107D Jardines del Pacifico IV
A rooftop pool with clear blue water, wooden deck, and lounge chairs.

19. Coquimbo from Above: Ocean View + Panoramic Pool, Self-Check-In 24/7

Coquimbo from Above: Ocean View + Panoramic Pool, Self-Check-In 24/7
Coquimbo
The price is ￥8,558
￥14,580 total
Nov 10 - Nov 11
Coquimbo from Above: Ocean View + Panoramic Pool, Self-Check-In 24/7
A hotel room with a bed, a nightstand, a lamp, a mirror, and a window with a view of a pool and high-rise buildings.

20. New Listing

New Listing
Coquimbo
The price is ￥7,924
￥16,878 total
Nov 10 - Nov 11
New Listing
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Find vacation rentals that suit your style

Apartment image
Apartments
Apartments
apart-hotel image
Aparthotels
Aparthotels

Top La Serena Hotel Reviews

A clear pool surrounded by rocks and vegetation, with a mountain in the background.
REFUGIO EL MOLLE

REFUGIO EL MOLLE

REFUGIO EL MOLLE
Vicuña

10/10 Excellent

Great
United States
America
Reviewed July 25, 2025
REFUGIO EL MOLLE

Find out more about La Serena

Search for holiday rentals in La Serena on Expedia! You can easily find your home rentals, villas, holiday apartments in La Serena using one of the methods below:

  • View our selection of featured holiday rentals in La Serena
  • Use the map to find apartments and other holiday homes in the La Serena neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in La Serena while they last

Look no further and take a look at our great range of rental properties in La Serena!

Frequently Asked Questions

Can I find a vacation rental in La Serena?

Yes, we give you a choice of vacation rentals in La Serena near Jardin del Corazon, or you can go with a more remote option if you're looking for a relaxing stay. La Serena is known for its sightseeing tours and spas. Make sure you have time to check out the casinos while you're in the area.

What are some of the best vacation rentals in La Serena?

Lagoon beach marina 312: Visitors like this La Serena vacation home rental. It comes with laundry facilities so you can feel at home during your trip. Some other homes for rent in La Serena include lagoon beach white 803 and Dept. 4th Floor, Pacífico II.

How many vacation rentals will I find in La Serena?

With 48 Expedia vacation rentals, you're sure to find just the right place for your La Serena stay.

What can I see and do in La Serena?

Cultural attractions include Casa Gabriel Gonzalez Videla Historical Museum and Mineralogical Museum, whereas La Serena Beach and Cuatro Esquinas Beach are a couple of picturesque spots to enjoy the outdoors. While here, La Recova Market and Mall Plaza La Serena are other places worth a visit.

What are vacation rentals like in La Serena?

Vacation rentals are private accommodations you can reserve for a short or long stay in La Serena. Vacation rentals provide amenities like kitchens and laundry facilities so you'll be comfy for your stay. If you're concerned about a sanitized environment, a vacation rental can offer a sense of security away from public hotel elevators and busy reception areas while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a great option for a family trip.