Weather will likely play an important role when you plan your trip to Guadalupe, and keep in mind that cheaper options are usually available when the weather isn't as good. The hottest months are usually September and October with an average temp of 64°F, while the coldest months are July and August with an average of 63°F. The rainiest months in Guadalupe are March, February, January, and April, with each month seeing an average of 12 inches of rainfall.