Three red brick buildings with chimneys, surrounded by green grass and trees under a clear blue sky.

Vacation Rentals in Lewis County

Dates

November 2026

December 2026

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Top cities in Lewis County

A river with a bridge, autumn foliage, and a clear sky.

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In two weeks

In two months

In three months

In four months

Our top choices for Lewis County vacation rentals

A modern kitchen with white cabinets, a refrigerator, microwave, and a coffee maker.

1. Charming 1-bedroom cottage in Lewistown!

lewistown

Joseph P.

￥30,710 total

includes taxes & fees

Nov 17 - Nov 18

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

2. Lighthouse Inn & Suites

Hannibal

Connie

￥30,867 total

includes taxes & fees

Nov 10 - Nov 11

A modern house with a stone facade, a dark garage door, and a well-lit entrance.

3. Cool 2-bedroom three bed contemporary condo in a quiet area of Quincy.

Quincy

G K.

￥34,142 total

includes taxes & fees

Nov 10 - Nov 11

A modern kitchen with white cabinets, stainless steel appliances, and a wooden floor.

4. Spacious & Modern 2BR Home with Attached Garage

Quincy

Jeff C.

￥31,486 total

includes taxes & fees

Nov 15 - Nov 16

A modern kitchen with stainless steel appliances, a stone accent wall, and a bar area.

5. Aunt Lele's Cozy Cottage

Quincy

Matt B.

￥27,456 total

includes taxes & fees

Nov 11 - Nov 12

A wooden-paneled room with a bed, a nightstand, a wall-mounted mirror, and a small shelf with decorative items.

6. Tiny Cozy Cottage in Edina, MO

Edina

John

￥15,023 total

includes taxes & fees

Nov 10 - Nov 11

A room with a brick wall, shelves with plants, a framed painting, and a patterned bench.

7. Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

Hannibal

Steve G.

￥26,459 total

includes taxes & fees

Dec 1 - Dec 2

A dining area with a wooden table and chairs, a chandelier, and a red sofa in the background.

8. Vibey home a few blocks from downtown Hannibal

Hannibal

Terry

￥44,711 total

includes taxes & fees

Nov 12 - Nov 13

A natural outdoor setting with a stone fire pit surrounded by wooden benches and a wooden bridge.

9. Your home away from home in the Country

Coatsburg

Dan A.

￥28,721 total

includes taxes & fees

Nov 23 - Nov 24

A modern kitchen with white cabinets, a stainless steel refrigerator, and a dining area with a wooden table and white chairs.

10. Peaceful, Country Cottage with Open Floor Plan

Quincy

Jodi

￥39,469 total

includes taxes & fees

Nov 12 - Nov 13

A cozy living room with a wooden staircase, a chessboard on a round table, and a lamp on a side table.

11. The John Sydney House - Family and Pet Friendly Historic Home Downtown

Hannibal

Brian H.

￥35,201 total

includes taxes & fees

Nov 10 - Nov 11

A bedroom with a bed, a desk, a chair, a TV, and a window.

12. Updated efficiency unit attached to the Parlor on Paris - Rent both and save

Hannibal

Jordon S.

￥34,051 total

includes taxes & fees

Nov 16 - Nov 17

A modern living room with a sofa, a wooden dining table with stools, a kitchen area with cabinets and a TV, and a hallway leading to a door.

13. Family friendly 3 bedroom home in Kahoka MO

Kahoka

Jay M.

￥28,336 total

includes taxes & fees

Nov 10 - Nov 11

A building with a glass door marked "108" and a sign for "Web Print Radio Television Public Relations."

14. The Library, 1-queen bed, 1-bedroom apartment in Hannibal awaits your visit.

Hannibal

Dan R.

￥22,698 total

includes taxes & fees

Nov 10 - Nov 11

A residential building with a wooden deck, outdoor seating, and a trash can.

15. Historical German Apartment

Bethel

￥22,579 total

includes taxes & fees

Nov 10 - Nov 11

A wooden staircase with a metal railing leading to a landing.

16. Cozy 3 bedroom cabin, country setting, North East Missouri

Luray

Martin S.

￥35,832 total

includes taxes & fees

Nov 30 - Dec 1

A bedroom with a bed, nightstands, a TV, a chair, and a door.

17. Charming 3-bedroom basement apartment, 2-car garage, and pickleball court

Hannibal

Jeanne M.

￥39,436 total

includes taxes & fees

Dec 2 - Dec 3

A kitchen with a window, a sink, a toaster, and potted plants.

18. Unique 2-bedroom house in Edina for a relaxing getaway

Edina

Robin W.

￥15,177 total

includes taxes & fees

Nov 16 - Nov 17

A kitchen with a stove, a dining table with chairs, a sofa, and a hallway leading to a door.

19. The Luxe BnB

Quincy

￥47,669 total

includes taxes & fees

Dec 6 - Dec 7

A kitchen with wooden cabinets, a stainless steel stove, a dishwasher, and a brick wall.

20. Stay Above Main Street Historic Hannibal Loft

Hannibal

￥55,528 total

includes taxes & fees

Nov 22 - Nov 23

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Find vacation rentals that suit your style

Top Lewis County Hotel Reviews

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

Oak Hill Inn & Suites

Canton

10/10 Excellent

Anonymous traveler

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

Sleep Inn & Suites Hannibal West

Hannibal

10/10 Excellent

Linda D

A hotel room with a bed, a lamp, a mirror, and a door.

Town & Country Inn and Suites

Quincy

10/10 Excellent

We live an hour from Quincy. We had several medical appts lined up and stayed overnight to facilitate that. We have stayed here more than once before, but I always forget that they don't have a microwave in the rooms. Be aware of that. I know there are several good reasons they only have one microwave in the hotel (in the Lobby), and it usually isn't a problem. But, this time, I had a sore throat and had brought tea bags with me and REALLY just wanted to make a cup of tea for my Daughter and I,...

Shelly

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

Best Western On The River

Hannibal

10/10 Excellent

Jean

A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.

Holiday Inn Quincy East by IHG

Quincy

10/10 Excellent

David

An indoor swimming pool with a wooden ceiling, grey tiled floor, and several lounge chairs and tables around the pool area.

Quality Inn & Suites Keokuk North

Keokuk

10/10 Excellent

Donna

A hotel lobby with a dining area, a bar, and a fireplace.

Fairfield Inn & Suites Quincy

Quincy

10/10 Excellent

Connie

A large indoor swimming pool with a lifeguard chair, poolside chairs, and a view of the outside through large windows.

Hampton Inn Keokuk

Keokuk

10/10 Excellent

Samuel

A modern kitchen with wooden cabinets, a granite countertop, a coffee machine, a microwave, a toaster, and a refrigerator.

Heritage Hotel Quincy

Quincy

10/10 Excellent

Amy

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

Quality Inn & Suites Hannibal West

Hannibal

10/10 Excellent

Pam

A hotel room with a bed, a desk, a chair, a television, and a window with curtains.

Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

Quincy

10/10 Excellent

Larry

A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.

Riverside Inn Hannibal

Hannibal

10/10 Excellent

Anonymous traveler

Lighthouse Inn & Suites

Hannibal

10/10 Excellent

Connie

A compact kitchen with a microwave, stove, and sink. There is a cabinet with a mirror above the sink and a small shelf above the microwave. The kitchen has a tiled floor and yellow walls.

Budget Inn

Keokuk

10/10 Excellent

Angela

A hotel room with a sofa, a bed, a desk, and a chair.

AmericInn by Wyndham Quincy

Quincy

10/10 Excellent

THOMAS

Find out more about Lewis County

Vacation Apartments in Lewis County

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Look no further and take a look at our great range of rental properties in Lewis County!

Vacation Rentals in Lewis County

Change your mind

Treat yourself

Be picky

Top cities in Lewis County

Canton

Check prices for these dates

Our top choices for Lewis County vacation rentals

1. Charming 1-bedroom cottage in Lewistown!

2. Lighthouse Inn & Suites

3. Cool 2-bedroom three bed contemporary condo in a quiet area of Quincy.

4. Spacious & Modern 2BR Home with Attached Garage

5. Aunt Lele's Cozy Cottage

6. Tiny Cozy Cottage in Edina, MO

7. Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

8. Vibey home a few blocks from downtown Hannibal

9. Your home away from home in the Country

10. Peaceful, Country Cottage with Open Floor Plan

11. The John Sydney House - Family and Pet Friendly Historic Home Downtown

12. Updated efficiency unit attached to the Parlor on Paris - Rent both and save

13. Family friendly 3 bedroom home in Kahoka MO

14. The Library, 1-queen bed, 1-bedroom apartment in Hannibal awaits your visit.

15. Historical German Apartment

16. Cozy 3 bedroom cabin, country setting, North East Missouri

17. Charming 3-bedroom basement apartment, 2-car garage, and pickleball court

18. Unique 2-bedroom house in Edina for a relaxing getaway

19. The Luxe BnB

20. Stay Above Main Street Historic Hannibal Loft

Find vacation rentals that suit your style

Top Lewis County Hotel Reviews

Oak Hill Inn & Suites

10/10 Excellent

Find out more about Lewis County

Vacation Apartments in Lewis County