A coastal town with colorful buildings, a prominent church with a blue dome, and a clear blue sea.

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Check availability on Syros 5 Star Hotels

Tonight
Sep 23 - Sep 24
Tomorrow
Sep 24 - Sep 25
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Syros 5-star hotels

A poolside area with lounge chairs and a view of the sea at night.
A modern bathroom with a large bathtub, wooden flooring, and a view of a cruise ship.
A modern, white-themed living room with a dining area, large windows offering a view of the sea, and a minimalist design.
A modern living room with a large rock feature, a white sofa, and a view of the sea.

1. CAVO TAGOO MYKONOS

CAVO TAGOO MYKONOS
Mykonos
United States
Aryana
￥91,537
￥106,918 total
includes taxes & fees
Oct 4 - Oct 5
CAVO TAGOO MYKONOS
A modern outdoor lounge area with a pool, seating, and a view of the sea.
A woman in a white dress overlooking a coastal town with white buildings and boats in the harbor.
A modern hotel room with a large bed, a desk, and a view of the ocean.
A modern room with a large window overlooking a body of water and a yacht. There is a sofa, a small round table, and a chair.

2. Myconian Deos - The Set

Myconian Deos - The Set
Mykonos
United States
Gisela
￥56,003
￥66,461 total
includes taxes & fees
Oct 24 - Oct 25
Myconian Deos - The Set
An infinity pool with lounge chairs and a sunset view.
A modern hotel room with a large bed, a flat-screen TV, a ceiling light, and a view of the outdoors.
A round table with a vase and two glasses, overlooking a body of water and distant land.
A corridor with a view of the sea and a distant mountain.

3. Myconian Korali Relais & Chateaux

Myconian Korali Relais & Chateaux
Mykonos
United Kingdom
Christopher
￥32,565
￥39,777 total
includes taxes & fees
Oct 24 - Oct 25
Myconian Korali Relais & Chateaux
An infinity pool with clear blue water, a white infinity pool edge, and a view of the sea with boats.
A modern hotel room with a large bed, a sofa, two round wooden tables, a TV, and a view of the sea and buildings.
A person lounging on a cushioned outdoor seating area with a view of the sea and a distant rocky island.
A pathway leading to a rocky beach area with white pebbles and agave plants, overlooking the sea.

4. Myconian Ambassador Hotel Relais & Chateaux

Myconian Ambassador Hotel Relais & Chateaux
Mykonos
United States
Monserrat
￥27,862
￥34,423 total
includes taxes & fees
Oct 24 - Oct 25
Myconian Ambassador Hotel Relais & Chateaux
A swimming pool with star-shaped lights at night.
A bedroom with a canopy bed, a wooden chair, and a view of the sea.
A marina with multiple yachts docked, rocky coastline, and buildings on the right.
A bedroom with a bed, a hanging lamp, a view of a pool, and a seating area with cushions and a bowl of fruit.

5. Palladium Hotel

Palladium Hotel
Mykonos
United States
Edmond
￥31,210
￥38,236 total
includes taxes & fees
Oct 1 - Oct 2
Palladium Hotel
A pool with clear blue water and white umbrellas.
A clear blue pool with a sailboat in the water and a distant shoreline.
A modern hotel room with a view of the ocean, a sitting area with a chair and a small table, and a large mirror on the wall.
A modern bedroom with a large bed, a bathtub, and a view of the sea.

6. Mykonos Riviera Hotel & Spa a member of Small Luxury Hotels of the World

Mykonos Riviera Hotel & Spa a member of Small Luxury Hotels of the World
Mykonos
United States
Alesia
￥53,192
￥63,260 total
includes taxes & fees
Oct 4 - Oct 5
Mykonos Riviera Hotel & Spa a member of Small Luxury Hotels of the World
A resort with multiple swimming pools, a beach area with umbrellas, and boats in the water.
A bedroom with a bed, a desk, and a view of the ocean.
A sunlit outdoor seating area with white furniture, a wooden coffee table, and a view of the sea with yachts.

7. Mykonos Blu, A Resort to Live

Mykonos Blu, A Resort to Live
Mykonos
United States
Hagop
￥52,442
￥62,409 total
includes taxes & fees
Oct 1 - Oct 2
Mykonos Blu, A Resort to Live
A modern outdoor pool area with lounge chairs and a fire feature.
An outdoor patio with a modern design, featuring a glass ceiling, seating areas, and a dining setup.
A modern, multi-level bedroom with a built-in hot tub, white blinds, and a stone wall backdrop.
A restaurant setting with tables set for dining, featuring candlelight and hanging lamps.

8. Semeli Hotel

Semeli Hotel
Mykonos
United States
Sonki
￥31,631
￥38,715 total
includes taxes & fees
Oct 3 - Oct 4
Semeli Hotel
A pool area with a view of the sea, stone walls, and a hanging chair.
A coastal beach with clear turquoise waters, a sandy shore, and several boats.
A multi-story hotel with stone architecture, a pool area with lounge chairs, and a view of rocky terrain.
A rooftop terrace with a wooden pergola, stone walls, a cushioned seating area, and a view of the ocean.

9. Tropicana Suites & Villas

Tropicana Suites & Villas
Mykonos
United States
Azmira
￥54,024
￥64,210 total
includes taxes & fees
Sep 25 - Sep 26
Tropicana Suites & Villas
A swimming pool with a clear view of the water, a white poolside area, and two empty glasses on a white surface.
A spacious indoor area with a high ceiling, modern chandeliers, and a view of the sea through large windows.
A waterfront resort with outdoor seating, a pool, and boats in the background.
A modern building with a stone facade and a clear sky.

10. Nissaki Boutique Hotel

Nissaki Boutique Hotel
Mykonos
United States
Melissa
￥26,411
￥32,774 total
includes taxes & fees
Oct 19 - Oct 20
Nissaki Boutique Hotel
A pool with a view of the sea and mountains, a yacht in the distance, and a cactus garden.
A view from a window of a room with a wooden ceiling, a stone wall, and a poolside area with a table and chairs.
A beach with lounge chairs and umbrellas, a woman in a swimsuit walking, and clear blue water.
A modern interior with a large window offering a coastal view, a wooden table, a cushioned chair, and a fireplace.

11. Bill&Coo Mykonos

Bill&Coo Mykonos
Mykonos
Canada
Matthew
￥55,695
￥66,112 total
includes taxes & fees
Oct 23 - Oct 24
Bill&Coo Mykonos
A white and blue room with a pool, a white chair, a blue table, and a white umbrella.
A white building with a red roof, a cross on top, and a large bougainvillea tree in front.
A spacious living area with a wooden ceiling, white sofas, a central coffee table, and potted plants.
A bedroom with a bed, a desk, a chair, a television, and a view of the outside.

12. San Antonio Summerland

San Antonio Summerland
Mykonos
United States
Charles Edward
￥24,320
￥30,393 total
includes taxes & fees
Sep 24 - Sep 25
San Antonio Summerland
A poolside area with lounge chairs, umbrellas, and boats.
A rooftop terrace with a hot tub, lounge chairs, and a view of the sea.
A modern bedroom with a large bed, a view of boats and a coastal landscape through a sliding door, and a small table with a chair.
A modern multi-level residential building with multiple swimming pools, outdoor seating areas, and a rooftop garden.

13. Once in Mykonos - Designed for Adults

Once in Mykonos - Designed for Adults
Mykonos
United States
Dmitry
￥46,178
￥55,278 total
includes taxes & fees
Oct 1 - Oct 2
Once in Mykonos - Designed for Adults
A poolside view with a clear blue sea and a mountain in the distance.
A restaurant with tables and chairs arranged to face a large window overlooking a beach and ocean.
A coastal landscape with clear turquoise waters, rocky shoreline, and a sandy beach.
An outdoor dining area with wooden tables and chairs, stone walls, and a view of the sea.

14. Saint John Hotel Villas & Spa

Saint John Hotel Villas & Spa
Mykonos
United States
Nicholas
￥31,207
￥38,233 total
includes taxes & fees
Oct 10 - Oct 11
Saint John Hotel Villas & Spa
A poolside dining area with a table set for two, overlooking a pool with a view of the sea and distant hills.
A coastal view with a clear blue sea, a sandy beach, and a distant hill with buildings.
A rooftop lounge area with sun loungers, a large tree, and a view of the sea.
A modern hotel room with a bed, a sofa, a desk, and a TV.

15. Grace Mykonos

Grace Mykonos
Mykonos
United States
Lindita
￥27,409
￥33,909 total
includes taxes & fees
Sep 26 - Sep 27
Grace Mykonos
A rooftop pool area with seating and a view of the city.
A modern living room with a sofa, patterned cushions, and wall-mounted lights.
A modern room with a large window overlooking a pool and a scenic view. There is a dining table with a bottle and a book, and a sofa with cushions.
A modern bedroom with a large bed, a small sofa, and a view of the sea.

16. Nomia Sunset Suites Mykonos

Nomia Sunset Suites Mykonos
Mykonos
United States
Gabriel
￥34,588
￥42,083 total
includes taxes & fees
Oct 4 - Oct 5
Nomia Sunset Suites Mykonos
A poolside area with lounge chairs and a view of the sea.
A resort with a central swimming pool, lounge areas, and a patio with outdoor seating.
A poolside area with two lounge chairs and an umbrella, overlooking a calm sea with boats and a hilly landscape in the background.
A bar area with a view of the sea and a hillside.

17. Kalesma Mykonos

Kalesma Mykonos
Mykonos
United States
Neal
￥93,403
￥109,039 total
includes taxes & fees
Oct 5 - Oct 6
Kalesma Mykonos
A modern building with a pool, set against a rocky coastline and the sea.
A bedroom with a bed, a lamp, a door, and a window.
A modern interior with a water feature, large rocks, and a minimalist design.
A modern building with multiple levels and balconies, surrounded by large rocks.

18. Armacaas Mykonos Hotel

Armacaas Mykonos Hotel
Mykonos
United States
Yarleny
￥29,067
￥35,797 total
includes taxes & fees
Sep 24 - Sep 25
Armacaas Mykonos Hotel
A modern outdoor lounge area with a pool, wooden pergola, and hanging chairs.
A beach with yellow and white umbrellas, a sandy area, and a view of the sea and distant mountains.
A bar area with wicker chairs, wooden tables, and pendant lighting.
A beachside restaurant with wicker furniture, stone pillars, and umbrellas overlooking the sea.

19. Santa Marina, a Luxury Collection Resort, Mykonos

Santa Marina, a Luxury Collection Resort, Mykonos
Mykonos
United Kingdom
FLORENCE
￥88,160
￥103,074 total
includes taxes & fees
Oct 6 - Oct 7
Santa Marina, a Luxury Collection Resort, Mykonos
A modern kitchen with a stone accent wall, wooden cabinets, and a view of the sea.
A modern living room with a dining area, a flat-screen TV mounted on the wall, and a cozy seating area with a sofa and a side table.
A spa area with a stone wall, a reception desk, and shelves with spa products.
A modern hotel room with a large bed, a sofa, a dining area, and a view of the city.

20. Tinos Beach Hotel

Tinos Beach Hotel
Tinos
Canada
Scott
￥27,785
￥34,338 total
includes taxes & fees
Sep 24 - Sep 25
Tinos Beach Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syros

Wander through Ermoupoli's neoclassical buildings and marble squares before catching a performance at the historic Apollo Theater. Swim at Galissas beach, then climb the hill to Ano Syros where medieval streets offer spectacular views across the Aegean.

See all hotels in Syros
A cobblestone street lined with colorful buildings, a prominent yellow church with a blue dome, and a clear blue sky.

Top Syros Hotel Reviews

Palladium Hotel

Palladium Hotel

10/10 Excellent
"The staff were amazing."
Kevin 3-night trip
Posted 14 hours ago
Palladium Hotel
Myconian Ambassador Hotel Relais & Chateaux

Myconian Ambassador Hotel Relais & Chateaux

10/10 Excellent
"This is a beautiful top-notch hotel. We were greeted at the door, shown to a quiet sitting area and given a drink while a reception staff member collected our passports and checked us in. Since we were an early morning arrival and our room was not ready, we were shown where we could change and headed up to the pool to relax while we waited for our room to be prepared. The staff assured us our room would be a priority, and true to their word, it was ready for us at 1p. While we waited, we also took lunch at the poolside restaurant. It was fresh and delicious. The restaurant staff then, at lunch, and at breakfast every day could not have been any more accommodating. Speaking of breakfast, what a beautiful simple, clean, but well stocked buffet that included pretty much anything you would like to eat. What I especially appreciated was having my eggs cooked to order, since I follow a strict diet for health reasons. The nightly turn down service, the private pool, and the extra towels delivered to our door are just a few of the additional luxuries provided at this resort. Last, but equally important as all of the above was the kindness and helpfulness of the staff. They booked and cancelled transfers for us at the last minute without a moment’s hesitation. They always had a smile, a warm hello, and were ready to assist at any time. I highly recommend the Myconian Ambassador Hotel. 9/21/2026"
Dolores 2-night trip
Posted 2 days ago
Myconian Ambassador Hotel Relais & Chateaux
Myconian Deos - The Set

Myconian Deos - The Set

10/10 Excellent
"Beautiful property!!! ⭐️⭐️⭐️⭐️⭐️"
John 4-night trip
Posted 9 days ago
Myconian Deos - The Set

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Syros?
There are a range of pricing options for a 5-star hotel in Syros on Expedia. How much you'll pay will depend on when you want to travel, length of stay and other factors. Compare available accommodations for your desired dates and make use of our pricing and other filters to land the perfect luxury stay.
  • Search for the lowest price per night from ￥28,201
What makes a hotel 5 stars in Syros?
Exceptional guest service is integral to every 5-star hotel in Syros. From the second you arrive, staff ensure your every need is met, whether arranging customized tours or providing in-room massage treatments. In addition, hotels must feature top-rate amenities to be considered for a 5-star rating. These can include luxury bathrooms, an on-site spa, swimming pools, fine dining kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Syros?
Expedia's filter tool is the best way to narrow down what you want. Select "All inclusive" and "5-star" to see the most luxurious resorts in Syros where your meals, accommodations, entertainment and activities are included in the price. At these stays, your trip is pure extravagance from the moment you pull up to the entrance.