Find 5 Star Hotels in Florida Keys from ￥20,810

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Check availability on Florida Keys 5 Star Hotels

Tonight
Aug 31 - Sep 1
Tomorrow
Sep 1 - Sep 2
Next weekend
Sep 5 - Sep 7
In two weeks
Sep 12 - Sep 14

Compare Florida Keys 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for Florida Keys 5-star hotels

Cheeca Lodge & Spa
Private beach, sun loungers, beach umbrellas, beach towels

Cheeca Lodge & Spa

5.0 star property
9.0 out of 10, Wonderful, (1176)
"amazing stay"
The price is ￥20,810
￥33,337 total
includes taxes & fees
Sep 4 - Sep 5
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa
Property grounds

Isla Bella Beach Resort & Spa

5.0 star property
9.2 out of 10, Wonderful, (1046)
"Property is beautiful, clean and staff was very friendly. We will definitely return and stay more days!!!"
The price is ￥31,514
￥44,127 total
includes taxes & fees
Sep 10 - Sep 11
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

97000 Overseas Hwy, Key Largo, FL
The price is ￥37,373 per night from Sep 7 to Sep 8
￥37,373
￥50,152 total
Sep 7 - Sep 8
includes taxes & fees
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Swim with dolphins, snorkel over coral reefs, visit Ernest Hemingway’s home or just relax on a beach and enjoy the balmy climate of this beautiful group of islands.

See all hotels in Florida Keys
Higgs Beach showing a sandy beach and tropical scenes as well as a large group of people

Top Florida Keys Hotel Reviews

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Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
You can find several pricing options for a 5-star hotel in Florida Keys on Expedia. The amount you pay will depend on your travel dates, length of your trip and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to score the ideal upscale stay.

  • Search for the lowest price per night from ￥23,520

What makes a hotel 5 stars in Florida Keys?
From gourmet restaurants and 24-hour gyms to pools and deluxe bedding, the 5-star experience in Florida Keys is all about comfort and indulgence. But it calls for more than just top-notch perks to earn a 5-star rating. Stays must also provide outstanding guest-focused services like in-room massage treatments, on-site laundry and dry cleaning and 24/7 room service.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find an indulgent escape that includes your lodging, meals, drinks and entertainment in Florida Keys with Expedia's filters. Search for hotels rated 5 stars and click on the "All inclusive" filter. Double-check what's included in the upfront price. This way, you'll be ready to maximize all the premium perks from the moment you arrive.