Find 5 Star Hotels in Florida Keys from ￥36,698
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Sep 7 - Sep 8Tomorrow
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Sep 18 - Sep 20Our top choices for Florida Keys 5-star hotels
￥23,283
￥37,621 total
includes taxes & fees
Sep 15 - Sep 16
￥30,274
￥43,341 total
includes taxes & fees
Sep 13 - Sep 14
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Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Reefhouse Resort & Marina
103800 Overseas Hwy Key Largo FL
￥34,221
￥44,749 total
Sep 8 - Sep 9
includes taxes & fees
9.2/10 Wonderful! (1,530 reviews)
Baker's Cay Resort Key Largo, Curio Collection by Hilton
97000 Overseas Hwy Key Largo FL
￥37,030
￥50,274 total
Sep 28 - Sep 29
includes taxes & fees
8.6/10 Excellent! (1,182 reviews)
Amara Cay Resort
80001 Overseas Hwy Islamorada FL
￥22,463
￥36,698 total
Sep 14 - Sep 15
includes taxes & fees
8.8/10 Excellent! (1,313 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Florida Keys
Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.
See all hotels in Florida Keys
Top Florida Keys Hotel Reviews
Isla Bella Beach Resort & Spa
10/10 Excellent
"Amazing stay- will come back! Totally recommend"
Frequently asked questions
How much does it cost to stay in a 5-star hotel in Florida Keys?
You can find several pricing options for a 5-star hotel in Florida Keys on Expedia. The amount you pay will depend on your travel dates, length of your trip and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to score the ideal upscale stay.
- Search for the lowest price per night from ￥36,698
What makes a hotel 5 stars in Florida Keys?
From gourmet restaurants and 24-hour gyms to pools and deluxe bedding, the 5-star experience in Florida Keys is all about comfort and indulgence. But it calls for more than just top-notch perks to earn a 5-star rating. Stays must also provide outstanding guest-focused services like in-room massage treatments, on-site laundry and dry cleaning and 24/7 room service.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find an indulgent escape that includes your lodging, meals, drinks and entertainment in Florida Keys with Expedia's filters. Search for hotels rated 5 stars and click on the "All inclusive" filter. Double-check what's included in the upfront price. This way, you'll be ready to maximize all the premium perks from the moment you arrive.