Find hotels in Santa Fe, Medellin

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Dec 29 - Dec 30
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Dec 30 - Dec 31
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Jan 2 - Jan 4
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Jan 9 - Jan 11

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Our top choices for Santa Fe hotels

Front of property
Hotel Boutique Olaya 54

Hotel Boutique Olaya 54

Hotel Boutique Olaya 54
3.0 star property
Santa Fe
10.0 out of 10, Exceptional, (1)
"Convenient and cozy . Per friendly was a plus ! "
United States
Alfonso
The price is ￥9,148
￥9,148 total
Dec 31 - Jan 1, 2026
Hotel Boutique Olaya 54
Breakfast area
Ayenda Casa San Pablo

Ayenda Casa San Pablo

Ayenda Casa San Pablo
2.5 star property
Santa Fe
8.0 out of 10, Very Good, (7)
"Room was very small, the bathroom tiny and uncomfortable to navigate. Facilities were clean and the staff courteous."
United States
Jose
The price is ￥8,697
￥8,697 total
Jan 30 - Jan 31, 2026
Ayenda Casa San Pablo
Restaurant
Hotel Attic 33

Hotel Attic 33

Hotel Attic 33
3.0 star property
Laureles, 1.9 km from Santa Fe
9.6 out of 10, Exceptional, (16)
"Clean room, staff, love the place."
United States
Luis
The price is ￥7,721
￥7,721 total
Jan 11 - Jan 12, 2026
Hotel Attic 33
Presidential Suite | Premium bedding, minibar, in-room safe, blackout drapes
Hotel Once22

Hotel Once22

Hotel Once22
3.0 star property
8.9 km from Santa Fe
9.6 out of 10, Exceptional, (32)
"Great stay as usual, wonderful service from check-in to check-out"
United States
Al
The price is ￥9,588
￥9,588 total
Jan 6 - Jan 7, 2026
Hotel Once22
Terrace/patio
Fairfield by Marriott Medellin Sabaneta

Fairfield by Marriott Medellin Sabaneta

Fairfield by Marriott Medellin Sabaneta
3.5 star property
8.4 km from Santa Fe
9.4 out of 10, Exceptional, (244)
"great location "
United States
Juliana
The price is ￥11,230
￥11,230 total
Jan 30 - Jan 31, 2026
Fairfield by Marriott Medellin Sabaneta
Restaurant
ibis budget Medellín Itagüí Metro

ibis budget Medellín Itagüí Metro

ibis budget Medellín Itagüí Metro
3.0 star property
6.9 km from Santa Fe
9.0 out of 10, Wonderful, (404)
"Great location with clean rooms!"
United States
Camila
The price is ￥7,188
￥7,188 total
Jan 3 - Jan 4, 2026
ibis budget Medellín Itagüí Metro
Garden
4 Sur Hotel

4 Sur Hotel

4 Sur Hotel
3.0 star property
Guayabal, 1.8 km from Santa Fe
9.4 out of 10, Exceptional, (203)
"Very good place to enjoy the stay"
United States
Alberto
The price is ￥11,128
￥11,635 total
Dec 31 - Jan 1, 2026
4 Sur Hotel
Deluxe Twin Room, Multiple Beds, City View | Premium bedding, minibar, in-room safe, desk
Arame Hotel

Arame Hotel

Arame Hotel
3.0 star property
5.6 km from Santa Fe
9.2 out of 10, Wonderful, (177)
"Great staff, clean rooms, helpful service, and very good breakfast"
United States
August
The price is ￥16,107
￥16,107 total
Jan 11 - Jan 12, 2026
Arame Hotel
Lobby sitting area
Hotel Nutibara

Hotel Nutibara

Hotel Nutibara
3.0 star property
La Candelaria, 3.8 km from Santa Fe
7.4 out of 10, Good, (538)
"Good, staff very friendley. "
United States
Robert
The price is ￥13,581
￥13,581 total
Jan 30 - Jan 31, 2026
Hotel Nutibara
Panoramic Loft, 1 King Bed | Down comforters, in-room safe, desk, laptop workspace
Firenze Lofts

Firenze Lofts

Firenze Lofts
3.0 star property
La América, 4 km from Santa Fe
9.6 out of 10, Exceptional, (383)
"Clean room and staff was amazing."
United States
Janny
Firenze Lofts
Outdoor pool
La Quinta by Wyndham Medellin

La Quinta by Wyndham Medellin

La Quinta by Wyndham Medellin
3.5 star property
San Diego, 1.9 km from Santa Fe
8.8 out of 10, Excellent, (1010)
"Breakfast, clean room and room service amazing!"
United States
Lyandra Jiliénne
The price is ￥13,125
￥13,125 total
Jan 12 - Jan 13, 2026
La Quinta by Wyndham Medellin
Outdoor pool
Los Patios Cool Living

Los Patios Cool Living

Los Patios Cool Living
3.0 star property
Laureles, 2 km from Santa Fe
9.4 out of 10, Exceptional, (435)
"Great hotel, with very helpful and friendly staff! Highly recommended! "
United States
Sean
Los Patios Cool Living
Design Studio Suite, 1 Queen Bed, Non Smoking, Kitchenette | Living area | 43-inch Smart TV with cable channels, TV
Indie Universe Creative Hotel

Indie Universe Creative Hotel

Indie Universe Creative Hotel
2.5 star property
Laureles, 2.4 km from Santa Fe
8.4 out of 10, Very Good, (149)
"I love the designs of the room and views."
United States
Giovanni Blu
Indie Universe Creative Hotel
Superior Double Room, 1 Queen Bed | Minibar, in-room safe, desk, blackout drapes
Hotel Lagoon

Hotel Lagoon

Hotel Lagoon
3.5 star property
19 km from Santa Fe
9.2 out of 10, Wonderful, (302)
"Nice property, very good food, very relaxing."
United States
Kevin
The price is ￥20,978
￥20,978 total
Jan 6 - Jan 7, 2026
Hotel Lagoon
Exterior
Nakúa Stay + Work

Nakúa Stay + Work

Nakúa Stay + Work
2.5 star property
El Poblado, 2.4 km from Santa Fe
9.4 out of 10, Exceptional, (117)
"Everything was great . Clean "
United States
Gilberto
The price is ￥11,648
￥11,648 total
Jan 1 - Jan 2, 2026
Nakúa Stay + Work
Deluxe Double Room, City View | Minibar, in-room safe, individually decorated, individually furnished
Moa Select

Moa Select

Moa Select
3.0 star property
Belen, 2.5 km from Santa Fe
9.2 out of 10, Wonderful, (204)
"Clean and pretty rooms and excellent breakfast. "
United States
ALYNEL
The price is ￥7,534
￥7,534 total
Jan 20 - Jan 21, 2026
Moa Select
Reception
The Host Medellin Only Adults

The Host Medellin Only Adults

The Host Medellin Only Adults
3.0 star property
Astorga, 1.8 km from Santa Fe
9.8 out of 10, Exceptional, (13)
"Great ambience and room, excellent breakfast "
United States
Shailendra
The price is ￥23,406
￥23,406 total
Jan 2 - Jan 3, 2026
The Host Medellin Only Adults
Reception
Hotel Santiago de Arma

Hotel Santiago de Arma

Hotel Santiago de Arma
3.0 star property
16.7 km from Santa Fe
9.2 out of 10, Wonderful, (914)
"Very clean room and very friendly staff."
United States
Redding
Hotel Santiago de Arma
Indoor pool, outdoor pool, sun loungers
York Medellin, Curio Collection by Hilton

York Medellin, Curio Collection by Hilton

York Medellin, Curio Collection by Hilton
4.0 star property
El Poblado, 3.9 km from Santa Fe
9.6 out of 10, Exceptional, (1427)
"The rooms were clean, the view was stunning, and the staff were incredibly friendly and professional."
United States
RAMON
The price is ￥20,161
￥20,161 total
Jan 13 - Jan 14, 2026
York Medellin, Curio Collection by Hilton
Arcade
Diez Hotel Categoria Colombia

Diez Hotel Categoria Colombia

Diez Hotel Categoria Colombia
4.0 star property
Provenza, 2.3 km from Santa Fe
9.4 out of 10, Exceptional, (1008)
"This hotel is so good , stay here when I go to Medellin "
United States
Luis
The price is ￥18,102
￥18,102 total
Jan 7 - Jan 8, 2026
Diez Hotel Categoria Colombia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Fe

Find the best Santa Fe areas and neighborhoods for the activities you enjoy most.
El Castillo Museum which includes heritage architecture and a castle

El Poblado

Golden Blocks brimming with commercial activity, El Poblado offers vibrant nightlife at Lleras Park, cultural attractions like El Castillo Museum, and ample shopping options with multiple malls. Accessible via Medellín Metro and bus lines.

Rock of Guatape which includes mist or fog, tranquil scenes and a house

Laureles

Laureles is known for its ample dining options, and you can make a stop by Unicentro Shopping Center and Belén Andrés Escobar Sports Complex while in the area.

Provenza

While Provenza might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Golden Mile and Oviedo Shopping Center.

Laureles - Estadio

While you're in Laureles - Estadio, take in top sights like Atanasio Giradot Stadium or Unicentro Shopping Center, and hop on the metro to see more the city at Estadio Station or Suramericana Station.

Zona Rosa

While Zona Rosa isn't home to many top sights, Golden Mile and Oviedo Shopping Center are some notable places to visit nearby.

Top Santa Fe Hotel Reviews

Hotel San Fernando Plaza

Hotel San Fernando Plaza

10/10 Excellent
"As always, the best place to staying in Medellin "
Yuheiby 2-night trip
Posted 1 day ago
Hotel San Fernando Plaza

Frequently asked questions

What's it like in Santa Fe?
You'll be sure to have fun visiting Medellín's Santa Fe neighborhood. Consider a visit to Santa Fe Zoological Park as part of your Santa Fe travel plans.
How many hotels are there in Santa Fe?
If you're searching for places to stay in Medellín, choose from one of Expedia's 12 hotels and other accommodations in Santa Fe.
If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?
Yes! Most hotel bookings are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Add dates, click "Search", then use the filter option "fully refundable" to get the top deals on offer in Santa Fe.
Where can I learn more about changing or cancelling my trip to Santa Fe?
To access more information about updating your trip to Santa Fe or cancelling it, head over to our customer service page.
What is there to do around this Medellín neighborhood?
Santa Fe Zoological Park is an attraction you might want to check out while you're in Santa Fe. While you're out sightseeing, Medellin's Museum of Modern Art and Monterrey Comercial Mall are a couple of additional sights to visit in Medellín.