Santa Cruz Vacation Rentals

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Sep 19 - Sep 21
In one month
Oct 3 - Oct 5
In two months
Oct 31 - Nov 2
In three months
Nov 28 - Nov 30

Vacation Rentals in Santa Cruz

Our top choices for Santa Cruz vacation rentals

Mariposa Blanca Playa Lajas Large Modern Beach House
Outdoor pool

Mariposa Blanca Playa Lajas Large Modern Beach House

10.0 out of 10, Exceptional, (4)
"It was a beautiful home in the middle of nowhere. It is an 1 hour flight from Panama City and about an hour drive from Airport David. Once you are there it is so peaceful and self contained. Right on the beach of the Pacific Ocean and a cute little beach club down the road. Great set up for BBQ and swimming in the pool. Perfect for a quiet getaway with family. The host was helpful and quick to respond. My boys learned how to surf here."
Mariposa Blanca Playa Lajas Large Modern Beach House
A entire beach house in front of the Pacific for nature-loving families!
Outdoor pool

A entire beach house in front of the Pacific for nature-loving families!

10.0 out of 10, Exceptional, (6)
"The beautiful pictures do not do justice to the actual magnificence of the property and hosts. A thoroughly wonderful experience. "
A entire beach house in front of the Pacific for nature-loving families!
ANNSRENTAL Luxury Beachfront - Stunning Views - Private Pool - Steps
2 bedrooms, iron/ironing board, travel crib, WiFi

ANNSRENTAL Luxury Beachfront - Stunning Views - Private Pool - Steps

10.0 out of 10, Exceptional, (110)
"This was a great place to stay, with all kinds of interesting and fun stuff to do in close proximity. Hosts were amazing and very helpful. If you are thinking about staying in Boca Chica, you couldn’t do better! "
ANNSRENTAL Luxury Beachfront - Stunning Views - Private Pool - Steps
Relax and Unwind at Las Lajas Beach House
Outdoor pool

Relax and Unwind at Las Lajas Beach House

8.6 out of 10, Excellent, (9)
"Real nice place but the kitchen needs new proper pots and pans, silverware etc."
Relax and Unwind at Las Lajas Beach House
Ocean Front Villa in Boca Chica!
Outdoor pool

Ocean Front Villa in Boca Chica!

10.0 out of 10, Exceptional, (1)
"the property and surroundings is amazing, the cliff, the beach. everything was perfect except for the grill. the grill needs some serious cleaning or better yet, replacement of the insides. we wanted to use it but just could not. The main patio doors would not lock, made us who stayed in the main portion of the home feel uncomfortable. Other than those two items, 5 stars!"
Ocean Front Villa in Boca Chica!
Casa Nero Panama, Boca Chica, Chiriqui, on Playa Hermosa, with private infinity pool
Outdoor dining

Casa Nero Panama, Boca Chica, Chiriqui, on Playa Hermosa, with private infinity pool

Casa Nero Panama, Boca Chica, Chiriqui, on Playa Hermosa, with private infinity pool
Sand Dollar Villa
Boating

Sand Dollar Villa

3.5 star property
10.0 out of 10, Exceptional, (1)
"Excellent place !"
Sand Dollar Villa
Stunning Oceanfront 4-Bdrm Villa w/ Infinity Pool
On the beach, sun loungers, beach towels

Stunning Oceanfront 4-Bdrm Villa w/ Infinity Pool

10.0 out of 10, Exceptional, (2)
"Amazing! We loved our stay. We'll be doing this next year again."
Stunning Oceanfront 4-Bdrm Villa w/ Infinity Pool
Oceanfront Luxury Retreat: 2 Bed, 3 Bath Apartment w/Pool – Your Getaway Awaits!
Outdoor pool

Oceanfront Luxury Retreat: 2 Bed, 3 Bath Apartment w/Pool – Your Getaway Awaits!

10.0 out of 10, Exceptional, (3)
"Beautiful quiet spot. Great pool!"
The price is ￥25,909
￥28,870 total
includes taxes & fees
Sep 12 - Sep 13
Oceanfront Luxury Retreat: 2 Bed, 3 Bath Apartment w/Pool – Your Getaway Awaits!
Magnificient Beachfront Estate House on the Pacific Coast
Pool

Magnificient Beachfront Estate House on the Pacific Coast

Magnificient Beachfront Estate House on the Pacific Coast
Charming 2-bedroom, 2.5 bath Over-water House on Secluded Beach!
Property grounds

Charming 2-bedroom, 2.5 bath Over-water House on Secluded Beach!

Charming 2-bedroom, 2.5 bath Over-water House on Secluded Beach!
Charming 2-bedroom ocean view garden apartment with private pool
Outdoor pool

Charming 2-bedroom ocean view garden apartment with private pool

Charming 2-bedroom ocean view garden apartment with private pool
Casita Mapachin Isla Boca Brava
Property grounds

Casita Mapachin Isla Boca Brava

Casita Mapachin Isla Boca Brava
Magic Mountain Lodge
Exterior

Magic Mountain Lodge

3.0 star property
8.0 out of 10, Very Good, (1)
"Everything we needed to stay 2 nights ... we’ll done !"
Magic Mountain Lodge
Casa Laguna Studios Apartments
Outdoor pool

Casa Laguna Studios Apartments

3.0 star property
Casa Laguna Studios Apartments
Stilvolles Apartment in Las Lajas, Panamá
Terrace/patio

Stilvolles Apartment in Las Lajas, Panamá

Stilvolles Apartment in Las Lajas, Panamá
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, you can find vacation rentals near well known sights in Santa Cruz, or you can choose a more secluded option if you're looking for relaxation.

What's the top vacation rental in Santa Cruz?

A entire beach house in front of the Pacific for nature-loving families!: This vacation home rental near Santa Cruz is located by the ocean and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Kick off your shoes and enjoy yourself with a garden and a hot tub.

What’s there to see and do in Santa Cruz?

While you're exploring the area, Playa Las Lajas and Playa Grande are a couple of picturesque spots to get outside and enjoy nature. In the larger area, you’ll find Isla Silva de Afuera and Isla Silva de Tierra.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a couple of days or more in Santa Cruz. Vacation rentals feature amenities such as laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about cleanliness, vacation rentals can provide a sense of privacy away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also have more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for family trips.