San Isidro Vacation Rentals

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Check prices for these dates

In two weeks
Jan 2 - Jan 4
In two months
Feb 13 - Feb 15
In three months
Mar 13 - Mar 15
In four months
Apr 10 - Apr 12

Our top choices for San Isidro vacation rentals

3 bedrooms, WiFi
House

House

House
Jinotega
10.0 out of 10, Exceptional, (1)
"El apartamento tiene excelente ubicacion y el clima es estupendo. Lo que puede mejorar es ubicar una refrigedora (aunque sea pequeña) en el apartamento."
Mexico
Evelyn
The price is ￥3,786
￥6,941 total
includes taxes & fees
Dec 23 - Dec 24
House
Property grounds
Relájate y disfruta de Cabaña Apanas

Relájate y disfruta de Cabaña Apanas

Relájate y disfruta de Cabaña Apanas
Jinotega
The price is ￥15,775
￥20,508 total
includes taxes & fees
Dec 23 - Dec 24
Relájate y disfruta de Cabaña Apanas
Property grounds
Mil flores de Palsila es una cabaña de montaña con temperaturas de 18-24 grados.

Mil flores de Palsila es una cabaña de montaña con temperaturas de 18-24 grados.

Mil flores de Palsila es una cabaña de montaña con temperaturas de 18-24 grados.
Matagalpa
10.0 out of 10, Exceptional, (2)
"Beautiful gem!"
United States
Nikaulis B.
The price is ￥21,296
￥35,651 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Mil flores de Palsila es una cabaña de montaña con temperaturas de 18-24 grados.
Interior
A Thousand Flowers from Pacsila: CASA TEJAS

A Thousand Flowers from Pacsila: CASA TEJAS

A Thousand Flowers from Pacsila: CASA TEJAS
Matagalpa
The price is ￥15,775
￥20,508 total
includes taxes & fees
Dec 23 - Dec 24
A Thousand Flowers from Pacsila: CASA TEJAS
Property grounds
Casa Sunshine

Casa Sunshine

Casa Sunshine
Matagalpa
The price is ￥5,521
￥9,465 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Casa Sunshine
3 bedrooms, desk, iron/ironing board, free WiFi
Isabella House 54

Isabella House 54

Isabella House 54
2.0 star property
Matagalpa
The price is ￥22,085
￥25,240 total
includes taxes & fees
Dec 29 - Dec 30
Isabella House 54
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top San Isidro Hotel Reviews

Vera Eco-Resort

Vera Eco-Resort

10/10 Excellent
"This place is amazing!!!! The staff is super friendly and the location is beautiful "
Gabriela 1-night trip
Posted 1 month ago
Vera Eco-Resort

Find out more about San Isidro

Search for holiday rentals in San Isidro on Expedia! You can easily find your home rentals, villas, holiday apartments in San Isidro using one of the methods below:

  • View our selection of featured holiday rentals in San Isidro
  • Use the map to find apartments and other holiday homes in the San Isidro neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in San Isidro while they last

Look no further and take a look at our great range of rental properties in San Isidro!

Frequently asked questions

Can I find a vacation rental in San Isidro?

Yes, we give you a choice of vacation rentals close to popular sights in San Isidro, or you can go with a secluded option if you're looking for relaxation.

What are some of the best vacation home rentals in San Isidro?

Mil flores de Palsila es una cabaña de montaña con temperaturas de 18-24 grados.: Visitors like this San Isidro vacation home rental. It is located in the mountains and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a selection of games.

What’s there to see and do in San Isidro?

While you're exploring the area, Estanzuela Waterfall and Somoto are a couple of picturesque spots to get outside and enjoy nature. In the larger area, you’ll find Ruben Dario Museum and Esteli Cathedral.

What’s a vacation rental in San Isidro like?

A vacation rental is a private property you can book for a long or short time in San Isidro. Vacation rentals feature extras such as WiFi and washers and dryers so you'll have a home away from home. If you're concerned about a clean environment, a vacation rental can offer a sense of security away from public hotel elevators and lobbies bustling with people while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a hotel, which is another reason why a vacation rental is an attractive choice for family trips or small group gatherings.