The Best Hotels Closest to Louisville Science Center in Louisville for 2026

The entrance to the Kentucky Science Center with a large circular structure in the foreground.

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Our top choices for Louisville Science Center hotels

A wooden staircase with a balustrade leading to a landing.

A two-story brick building with a white porch and a sign reading "Hotel".

A brick building with a covered porch, columns, and potted plants.

A bedroom with a bed, a dresser, a television, and a desk with a lamp.

1. Market Street Inn

2.1 km from Louisville Science Center

Holly

￥34,658

￥39,164 total

includes taxes & fees

Oct 25 - Oct 26

A restaurant with a high ceiling, exposed brick walls, hanging plants, and a variety of seating arrangements.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

2. Hotel Distil, Autograph Collection

Downtown Louisville, 0.9 km from Louisville Science Center

Heather

￥34,375

￥40,446 total

includes taxes & fees

Nov 24 - Nov 25

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

3. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from Louisville Science Center

Casey

￥28,550

￥33,138 total

includes taxes & fees

Oct 25 - Oct 26

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

4. The Brown Hotel

Downtown Louisville, 1.2 km from Louisville Science Center

John

￥18,325

￥21,561 total

includes taxes & fees

Nov 24 - Nov 25

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

A lobby with a marble floor, a reception desk, and a large chandelier.

A modern interior with a fireplace, bookshelves, and seating areas.

5. Omni Louisville Hotel

Downtown Louisville, 0.8 km from Louisville Science Center

Kristan

￥31,847

￥37,472 total

includes taxes & fees

Nov 16 - Nov 17

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A swimming pool with lounge chairs and a view of the city.

6. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.2 km from Louisville Science Center

peter

￥18,064

￥21,254 total

includes taxes & fees

Nov 24 - Nov 25

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

A building with a sign reading "THE GRADY" at the entrance.

7. The Grady

Downtown Louisville, 0.2 km from Louisville Science Center

Donna

￥24,409

￥28,720 total

includes taxes & fees

Nov 15 - Nov 16

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A modern hotel room with a large bed, a city view, and a unique headboard design.

8. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from Louisville Science Center

Cameron

￥20,710

￥24,366 total

includes taxes & fees

Nov 24 - Nov 25

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

9. Stellar Suites

East Market District, 2.2 km from Louisville Science Center

Kevin

￥15,875

￥26,613 total

includes taxes & fees

Oct 27 - Oct 28

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

10. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from Louisville Science Center

Matt

￥23,846

￥28,841 total

includes taxes & fees

Nov 18 - Nov 19

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

11. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2.1 km from Louisville Science Center

Addison

￥18,266

￥21,493 total

includes taxes & fees

Nov 24 - Nov 25

An outdoor seating area with wicker furniture and a fire pit.

A modern lounge area with seating, tables, and a view of the city through large windows.

A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

12. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from Louisville Science Center

Derek

￥16,457

￥19,364 total

includes taxes & fees

Nov 8 - Nov 9

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

13. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

Alicia

￥18,517

￥21,786 total

includes taxes & fees

Nov 15 - Nov 16

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

A modern bar area with sofas, tables, and a bar stocked with bottles.

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

14. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

Anthony

￥19,184

￥22,572 total

includes taxes & fees

Nov 8 - Nov 9

A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

A modern lobby with a fireplace, seating area, and a reception desk.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern bar area with a circular bar, multiple seating options, and a large screen.

15. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from Louisville Science Center

Sarah

￥14,921

￥17,557 total

includes taxes & fees

Nov 22 - Nov 23

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

16. AC Hotel Louisville Downtown

East Market District, 2.1 km from Louisville Science Center

Jen

￥22,428

￥26,388 total

includes taxes & fees

Oct 31 - Nov 1

A covered patio with a stone wall, a glass table, and a bench.

A garden pathway with a lantern, potted plants, and a white fence.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

17. Central Park Bed & Breakfast

Old Louisville, 3 km from Louisville Science Center

Nicole

￥25,160

￥29,203 total

includes taxes & fees

Oct 25 - Oct 26

A restaurant with a long counter, multiple tables, and chairs. There are large windows with a view of the city.

A bedroom with a bed, a chair, a TV, and a window with curtains.

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

18. Hotel Genevieve part of JdV by Hyatt

East Market District, 2.1 km from Louisville Science Center

Tyler

￥21,159

￥24,895 total

includes taxes & fees

Oct 31 - Nov 1

A balcony with a view of a river, a bridge, and a cityscape.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

19. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from Louisville Science Center

Judy

￥21,334

￥25,100 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.

A modern hotel room with a living area, a dining area, and a bedroom.

A hotel dining area with long tables, booths, and a bar.

20. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from Louisville Science Center

Frances

￥19,149

￥22,532 total

includes taxes & fees

Nov 23 - Nov 24

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Compare popular hotels close to Louisville Science Center

Property	Star rating	Guest rating
Market Street Inn	9.8 Exceptional 125 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 512 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 150 reviews	View
The Brown Hotel	9.4 Exceptional 1,417 reviews	View
Omni Louisville Hotel	9.4 Exceptional 2,203 reviews	View

Top Louisville Science Center Hotel Reviews

Louisville Marriott Downtown

10/10 Excellent

"The staff that looked after our room were wonderful. So nice to pass by them and have a nice discussion. Lobby bar staff were true professionals."

Omni Louisville Hotel

10/10 Excellent

"Fantastique!"

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent

"The room was clean, close to activities and the breakfast was good."

Holiday Inn Louisville Downtown by IHG

8/10 Good

"The room we were given was extremely cramped for two people. It was located on the first floor next to an entrance, and you could feel it when the door was slammed."

The Brown Hotel

10/10 Excellent

"Perfect location for a show. Breakfast service slow"

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent

"Yes. They were very helpful and it was a great stay!"

Hyatt Regency Louisville

10/10 Excellent

"Great hotel"

The Grady

10/10 Excellent

"Great location and contemporary design. Wish there was a gym and also suggest they offer complimentary coffee in the morning like most hotels in the same category do."

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"déjeuner hors pair en plus de l'endroit propre et agréable"

Other attractions near Louisville Science Center

A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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The Frazier History Museum with red doors and a tree in front.

Frazier International History Museum

9.4/10 (10 reviews)

Get to know Louisville with a visit to this esteemed museum. It’s a great spot for social interaction as well.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Louisville Glassworks

You can spend an afternoon studying the exhibits at Louisville Glassworks in Louisville. Experience the area's lively festivals or attend a sporting event.

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Frequently asked questions

What's the area like around Louisville Science Center?

Louisville Science Center is located in an area of Louisville known for its beautiful river views, sporting events, and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Louisville Science Center?

Adjacent to Louisville Science Center, Holiday Inn Express & Suites Louisville Downtown by IHG is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.

How many hotels can I expect to find close to Louisville Science Center?

Expedia has 292 hotels and other accommodations within a mile from Louisville Science Center.

If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to review the best deals near Louisville Science Center.

Where can I learn more about changing or cancelling my trip in the area near Louisville Science Center?

For more details about picking new dates or cancelling your stay near Louisville Science Center, click here.

What can I see and do near Louisville Science Center?

21c Museum Hotel, Louisville Slugger Museum, and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can catch a show at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall.

Find hotels near Louisville Science Center, Louisville from ￥17,557

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Treat yourself

Be picky

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Our top choices for Louisville Science Center hotels

1. Market Street Inn

2. Hotel Distil, Autograph Collection

3. DuPont Mansion Bed & Breakfast

4. The Brown Hotel

5. Omni Louisville Hotel

6. Homewood Suites by Hilton Louisville Downtown, KY

7. The Grady

8. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

9. Stellar Suites

10. 21c Museum Hotel Louisville

11. Tempo By Hilton Louisville Downtown Nulu

12. Towneplace Suites By Marriott Louisville Downtown

13. Moxy Louisville Downtown

14. Aloft by Marriott Louisville Downtown

15. Cambria Hotel Louisville Downtown-Whiskey Row

16. AC Hotel Louisville Downtown

17. Central Park Bed & Breakfast

18. Hotel Genevieve part of JdV by Hyatt

19. Galt House Hotel Trademark Collection by Wyndham

20. Embassy Suites Louisville Downtown

Compare popular hotels close to Louisville Science Center

Top Louisville Science Center Hotel Reviews

Louisville Marriott Downtown

Omni Louisville Hotel

Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Louisville Downtown by IHG

The Brown Hotel

Homewood Suites by Hilton Louisville Downtown, KY

Hyatt Regency Louisville

The Grady

Towneplace Suites By Marriott Louisville Downtown

Other attractions near Louisville Science Center

Louisville Slugger Museum

Muhammad Ali Center

Frazier International History Museum

Kentucky Center for the Performing Arts

Kentucky Museum of Art and Craft

Golden Statue of David

SAR Genealogical Research Library: NSSAR Library

Louisville Glassworks

Frequently asked questions