The Best Hotels Closest to Louisville Science Center in Louisville for 2026

Q: What's the area like around Louisville Science Center?

Louisville Science Center is located in an area of Louisville known for its beautiful river views, sporting events, and great live music scene. If you're looking for a convenient place to stay, check out the 272 hotels and other accommodations you'll find within a mile.

Q: What's the best place to stay near Louisville Science Center?

Adjacent to Louisville Science Center, Homewood Suites by Hilton Louisville Downtown, KY is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel .

Q: How many hotels can I expect to find close to Louisville Science Center?

Expedia has 272 hotels and other accommodations within a mile from Louisville Science Center.

Q: If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to review the best deals near Louisville Science Center.

Q: Where can I learn more about changing or cancelling my trip in the area near Louisville Science Center?

For more details about picking new dates or cancelling your stay near Louisville Science Center, click here .

Q: What can I see and do near Louisville Science Center?

21c Museum Hotel, Louisville Slugger Museum, and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row, and Union Station. You can catch a show at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall.

Our top choices for Louisville Science Center hotels

Louisville Bourbon Inn

Old Louisville, 2.9 km from Louisville Science Center

"The property is beautiful. Our room was lovely—very clean and comfortable. The seating in our room was perfect for reading, and the balcony an extra treat. Allen was so gracious and helpful. The location was great for dinner plans and a short easy drive to Churchill Downs. Breakfast was delicious—especially the biscuits and gravy. And, the young lady that served us breakfast was very nice and helpful. I’d recommend this Bed and Breakfast to anyone who is planning to spend time in...

Nancy

￥57,629 total

includes taxes & fees

Jun 10 - Jun 11

Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.2 km from Louisville Science Center

Lateshia

￥24,099 total

includes taxes & fees

Jun 21 - Jun 22

The Grady

Downtown Louisville, 0.2 km from Louisville Science Center

Theodore

￥29,538 total

includes taxes & fees

Jun 26 - Jun 27

21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from Louisville Science Center

William

￥29,494 total

includes taxes & fees

Jul 3 - Jul 4

Luxury Suite, 1 King Bed, Fireplace | Bathroom | Jetted tub, free toiletries, hair dryer, towels

Market Street Inn

2.1 km from Louisville Science Center

Anissa

￥30,176 total

includes taxes & fees

Jun 15 - Jun 16

3 bars/lounges, cocktail bar, lobby lounge

Omni Louisville Hotel

Downtown Louisville, 0.8 km from Louisville Science Center

Cortney

￥29,999 total

includes taxes & fees

Jun 28 - Jun 29

The Brown Hotel

Downtown Louisville, 1.2 km from Louisville Science Center

Kate M

￥30,359 total

includes taxes & fees

Jun 28 - Jun 29

Stellar Suites

East Market District, 2.2 km from Louisville Science Center

Richard

￥28,320 total

includes taxes & fees

Jun 16 - Jun 17

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from Louisville Science Center

Kristen

￥32,296 total

includes taxes & fees

Jun 21 - Jun 22

Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from Louisville Science Center

Philip

￥20,972 total

includes taxes & fees

Jul 2 - Jul 3

Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from Louisville Science Center

Dana Jean

￥21,483 total

includes taxes & fees

Jun 28 - Jun 29

DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from Louisville Science Center

Michele

￥26,550 total

includes taxes & fees

Jun 10 - Jun 11

2 restaurants; breakfast and dinner served

Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2.1 km from Louisville Science Center

Monica

￥25,833 total

includes taxes & fees

Jul 2 - Jul 3

Moxy Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

David

￥21,296 total

includes taxes & fees

Jul 4 - Jul 5

4 restaurants; breakfast, lunch, and dinner served

Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from Louisville Science Center

Jacqueline

￥27,504 total

includes taxes & fees

Jun 27 - Jun 28

Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from Louisville Science Center

Natali

￥23,779 total

includes taxes & fees

Jun 14 - Jun 15

AC Hotel Louisville Downtown

East Market District, 2.1 km from Louisville Science Center

Jeffrey

￥18,859 total

includes taxes & fees

Jul 4 - Jul 5

Hotel Genevieve part of JdV by Hyatt

East Market District, 2.1 km from Louisville Science Center

Josh

￥25,439 total

includes taxes & fees

Jun 30 - Jul 1

Louisville Marriott Downtown

Downtown Louisville, 0.8 km from Louisville Science Center

Pete

￥31,602 total

includes taxes & fees

Jun 28 - Jun 29

Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

Sompathana

￥21,743 total

includes taxes & fees

Jun 29 - Jun 30

View all properties

Compare popular hotels close to Louisville Science Center

Property	Star rating	Guest rating
Louisville Bourbon Inn	5.0 star property	10.0 Exceptional 24 reviews	View
Homewood Suites by Hilton Louisville Downtown, KY	3.0 star property	9.4 Exceptional 1,007 reviews	View
The Grady	4.0 star property	9.4 Exceptional 1,012 reviews	View
21c Museum Hotel Louisville	4.5 star property	9.4 Exceptional 1,005 reviews	View
Market Street Inn	3.5 star property	9.8 Exceptional 121 reviews	View

Top Louisville Science Center Hotel Reviews

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"We had a great one-night stay at this hotel. It was clean, well-maintained, comfortable, and very family-friendly. The location was convenient and close to downtown. The breakfast was the highlight of our stay, fresh, well-stocked, and much better than expected. The only thing that could be improved is the parking. The parking garage was a bit of a walk from the hotel, which was slightly inconvenient when we needed to get something from the car. Other than that, we had a very pleasant stay and would definitely stay here again."

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent

"Only one luggage cart which is a pain. Room given was not what was booked, but they made up for it by offering an additional room to accommodate our party at a reduced rate and we made it work. The friendly staff and convenient location more than made up for it!"

Moxy Louisville Downtown

6/10 Okay

"Better stay for a couple, not great for families. The hotel room was designed for aesthetics and not for functionality. There was a large curtain that separated the bathroom from the sleeping area. This curtain through the entrance to the room so making showers and leaving the room difficult. Chair was uncomfortable, no practical luggage storage to keep luggage accessible. You have to put your luggage in a cubby under the bed. Check in was at the bar which made our late night check in difficult with dj and crowd. Everything was clean and the view from the room was beautiful. Staff was friendly and having a late night food option on site was nice for use arriving late."

Hotels near other Louisville Science Center attractions

Louisville Slugger Museum

4.6/5 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

See properties

Frequently asked questions

What's the area like around Louisville Science Center?

Louisville Science Center is located in an area of Louisville known for its beautiful river views, sporting events, and great live music scene. If you're looking for a convenient place to stay, check out the 272 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Louisville Science Center?

Adjacent to Louisville Science Center, Homewood Suites by Hilton Louisville Downtown, KY is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.

How many hotels can I expect to find close to Louisville Science Center?

Expedia has 272 hotels and other accommodations within a mile from Louisville Science Center.

If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to review the best deals near Louisville Science Center.

Where can I learn more about changing or cancelling my trip in the area near Louisville Science Center?

For more details about picking new dates or cancelling your stay near Louisville Science Center, click here.

What can I see and do near Louisville Science Center?

21c Museum Hotel, Louisville Slugger Museum, and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row, and Union Station. You can catch a show at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall.

Find hotels near Louisville Science Center, Louisville from ￥18,859

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Our top choices for Louisville Science Center hotels

Louisville Bourbon Inn

Homewood Suites by Hilton Louisville Downtown, KY

The Grady

21c Museum Hotel Louisville

Market Street Inn

Omni Louisville Hotel

The Brown Hotel

Stellar Suites

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Cambria Hotel Louisville Downtown-Whiskey Row

Towneplace Suites By Marriott Louisville Downtown

DuPont Mansion Bed & Breakfast

Tempo By Hilton Louisville Downtown Nulu

Moxy Louisville Downtown

Galt House Hotel Trademark Collection by Wyndham

Embassy Suites Louisville Downtown

AC Hotel Louisville Downtown

Hotel Genevieve part of JdV by Hyatt

Louisville Marriott Downtown

Aloft by Marriott Louisville Downtown

Compare popular hotels close to Louisville Science Center

Top Louisville Science Center Hotel Reviews

Towneplace Suites By Marriott Louisville Downtown

Hotels near other Louisville Science Center attractions

Louisville Slugger Museum

Frequently asked questions