The Best Hotels Closest to Lester E. Cox Medical Center South in Springfield for 2026

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Our top choices for Lester E. Cox Medical Center South hotels

A conference room with a granite table, cushioned chairs, a fruit bowl, framed pictures, and a flat-screen TV.

The exterior of Hampton Inn with a clear sign, a welcome sign, and a clearance height sign.

A business center with two computers, a printer, and a lamp. There are signs indicating the business center is available 24 hours and providing emergency and front desk contact information.

A living room with patterned armchairs, a dark sofa, a glass coffee table, and framed artwork on the walls.

1. Hampton Inn Springfield-South

Galloway Village, 2 km from Lester E. Cox Medical Center South

Ashley

￥16,683

￥18,935 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a blue sofa, two single beds, a nightstand, a lamp, and a framed picture on the wall.

A Holiday Inn Express & Suites hotel with a parking lot, a covered entrance, and a view of the surrounding area.

A living room with a blue sofa, a small round table, a patterned carpet, and a kitchenette area.

A coffee station with two coffee machines and a variety of coffee pods and cups.

2. Holiday Inn Express and Suites Springfield Medical District by IHG

1.6 km from Lester E. Cox Medical Center South

Loyola

￥21,210

￥24,075 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor patio area with red seating, a fire feature, and tables and chairs.

A modern hotel with a dark facade, multiple windows, and an American flag.

A modern hotel lobby with a bar, seating area, kitchen, and a TV.

A modern hotel room with a large bed, a desk with a chair, a mirror, and a painting on the wall.

3. Homewood Suites by Hilton Springfield Medical District

Southside, 1.4 km from Lester E. Cox Medical Center South

Aaron

￥20,637

￥23,426 total

includes taxes & fees

Oct 30 - Oct 31

A hotel room with two beds, a desk, a chair, a TV, and a bathroom with a sink and mirror.

A modern hotel room with a sofa, armchair, and a dining area with a kitchen in the background.

A modern kitchen with a stainless steel microwave, a coffee maker, and a refrigerator.

A multi-story hotel with a prominent "Candlewood Suites" sign, a parking lot, and a landscaped entrance area.

4. Candlewood Suites Springfield-Medical District

0.9 km from Lester E. Cox Medical Center South

Beau

￥18,677

￥21,198 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio area with wicker furniture, a central fire pit, and large windows.

A hotel with a stone facade, large windows, and a clear blue sky.

A lobby with a fireplace, large windows, and a view of the outdoors.

A spacious hotel lobby with high ceilings, large windows, and a central seating area with tables and chairs.

5. Hilton Garden Inn Springfield, MO

Lake Springfield, 2.7 km from Lester E. Cox Medical Center South

daryl

￥18,041

￥20,669 total

includes taxes & fees

Oct 31 - Nov 1

A spacious lounge area with comfortable seating, a fireplace, and artwork on the walls.

An outdoor patio with wicker furniture, a round table, and a grill area.

A hotel room with a desk, chair, TV, fireplace, bed, and a small dining area.

A modern kitchen with a central island, bar stools, a dining table, and a bar area.

6. Residence Inn by Marriott Springfield

Southside, 0.8 km from Lester E. Cox Medical Center South

Jacob

￥18,701

￥21,227 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with two beds, a desk with a computer, a TV, and a coffee maker.

An indoor swimming pool with a tiled floor, a pool ladder, and a glass door leading to another room.

A hotel dining area with multiple tables and chairs, a kitchen counter with coffee machines, and a wall-mounted clock.

A hotel reception area with a counter displaying various alcohol bottles, a menu board, and artwork on the walls.

7. La Quinta Inn & Suites by Wyndham Springfield South

Seminole Holland, 2.8 km from Lester E. Cox Medical Center South

Denise

￥14,182

￥16,388 total

includes taxes & fees

Oct 25 - Oct 26

A modern living room with a flat-screen TV, a fireplace, a sofa, and a dining area with a kitchen counter.

A modern living room with a fireplace, a sofa, a TV, and a staircase leading to a bedroom.

A compact kitchen with a microwave, toaster, and refrigerator.

A kitchen area with a coffee machine, a buffet setup, and a dining table with chairs.

8. MainStay Suites Springfield South - Battlefield Rd

Bradford Park, 1.7 km from Lester E. Cox Medical Center South

Arthur

￥14,665

￥16,645 total

includes taxes & fees

Nov 19 - Nov 20

An indoor swimming pool with a glass ceiling, surrounded by lounge chairs and a view of the outdoors.

A modern restaurant with a stone backsplash, wooden cabinets, and a herringbone floor pattern.

A modern living room with blue sofas, a stone accent wall, and a bookshelf.

A Comfort Inn hotel with a modern facade, a covered entrance, and a parking lot.

9. Comfort Inn South - Springfield

Galloway Village, 2.3 km from Lester E. Cox Medical Center South

Roger

￥15,043

￥17,075 total

includes taxes & fees

Nov 18 - Nov 19

A modern hotel lobby with a leather sofa, green chairs, a black coffee table, and a kitchen area with a green countertop.

A swimming pool with a lifeguard tower, surrounded by a fence and seating area.

A hotel room with two beds, a desk with a chair, a flat-screen TV, and a large window with curtains.

A hotel with a prominent sign, a covered parking area, and a well-lit entrance.

10. The Bradford Hotel, an Ascend Collection Hotel

Bradford Park, 0.5 km from Lester E. Cox Medical Center South

Richard

￥13,918

￥15,798 total

includes taxes & fees

Nov 21 - Nov 22

A hotel lobby with a reception desk, a staircase, and a seating area.

A kitchen with a wooden table and chairs, a coffee machine, a fruit juicer, and a refrigerator.

A modern hotel lobby with a sofa, armchairs, a coffee table, and a staircase.

A swimming pool with a hot tub, tiled floor, and a few lounge chairs.

11. Sleep Inn Springfield South I60 near Medical District

1.8 km from Lester E. Cox Medical Center South

Dina

￥13,547

￥15,377 total

includes taxes & fees

Nov 19 - Nov 20

A hotel room with a large bed, a chair, a nightstand, a lamp, and a door.

A hotel room with a brown leather sofa, a small table, a floor lamp, and a green accent wall.

A hotel reception area with a reception desk, a framed artwork, and an exit sign.

A compact kitchenette with white cabinets, a sink, a microwave, and a refrigerator.

12. Extended Stay America Select Suites Springfield South

Southside, 0.9 km from Lester E. Cox Medical Center South

Crystal

￥11,395

￥12,933 total

includes taxes & fees

Oct 30 - Oct 31

A hotel room with a bed, bedside table, lamp, and a painting of a sunset.

A modern dining area with blue chairs and white tables, a flat-screen TV mounted on the wall, and a wooden cabinet with items on it.

A lobby with a mural, seating area, and a refrigerator labeled 'NOURISH' and 'RECHARGE'.

13. Clarion Pointe Springfield Southeast

Galloway Village, 4.8 km from Lester E. Cox Medical Center South

Harish

￥13,110

￥14,879 total

includes taxes & fees

Nov 12 - Nov 13

A spacious indoor dining area with multiple tables and chairs, a kitchen area, and large windows allowing natural light.

A modern kitchen with a long counter, wooden cabinets, and a backsplash.

A spa area with a hot tub, a pool, and a seating area with tables and chairs.

A Drury Inn & Suites hotel with a modern design, featuring a prominent entrance and stone pillars.

14. Drury Inn & Suites Springfield, MO

11.2 km from Lester E. Cox Medical Center South

Michelle

￥16,776

￥19,210 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with two beds, a wooden headboard, bedside tables with lamps, and a small nightstand.

A vending machine stocked with beverages and a display of snacks.

A coffee station with two espresso machines, a coffee press, and various coffee cups and containers.

A Holiday Inn Express & Suites hotel with a modern design, featuring a clear entrance, an American flag, and a covered parking area.

15. Holiday Inn Express & Suites Springfield North by IHG

11.8 km from Lester E. Cox Medical Center South

Jerry

￥16,619

￥18,864 total

includes taxes & fees

Oct 25 - Oct 26

A cozy living room with a stone fireplace, comfortable seating, and a large mirror reflecting the room.

A hotel with a clear entrance, a covered waiting area, and a parking lot.

An indoor swimming pool with a clear water line, surrounded by lounge chairs and tables.

A hotel lobby with a large bar area, seating, a fireplace, and framed pictures on the walls.

16. Hampton Inn Springfield-Southeast

Galloway Village, 4.9 km from Lester E. Cox Medical Center South

teresa

￥17,759

￥20,158 total

includes taxes & fees

Nov 1 - Nov 2

A modern hotel room with a kitchenette, a flat-screen TV, a bed, and a large window.

A modern hotel room with a dark grey sofa, a wooden side table, a desk with a chair, and two abstract paintings on the walls.

A modern kitchen with wooden cabinets, a countertop with various kitchen items, and a wall-mounted shelf with decorative objects.

A hotel reception area with a modern design, including a reception desk, a wall with geometric patterns, and a minibar.

17. SpringHill Suites by Marriott Springfield North

Parkwood, 11.6 km from Lester E. Cox Medical Center South

Amanda

￥18,044

￥21,198 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio with stone walls, round tables, chairs, and umbrellas.

A modern hotel room with a stone accent wall, a flat-screen TV, a fireplace, a sofa, a dining area, and a patterned carpet.

An indoor swimming pool with clear glass walls, lounge chairs, and a lifeguard chair.

A modern living room with a wooden dining table, comfortable seating, a stone accent wall, and a large window.

18. Fairfield Inn & Suites by Marriott Springfield North

Doling, 10.7 km from Lester E. Cox Medical Center South

Kristal

￥16,575

￥19,196 total

includes taxes & fees

Nov 1 - Nov 2

A modern hotel room with a large bed, a desk with a sink, and a view of the cityscape through large windows.

A modern building with a prominent V-shaped entrance and large glass windows.

A rooftop lounge with wooden flooring, various seating options including sofas and chairs, a round table, and potted plants.

A modern kitchen with a large island, bar stools, a window with a city view, and pendant lighting.

19. Hotel Vandivort

Downtown Springfield, 6.8 km from Lester E. Cox Medical Center South

Bernard and Leisha

￥23,996

￥27,365 total

includes taxes & fees

Nov 8 - Nov 9

A modern breakfast area with a central island, bar stools, and a variety of food items and beverages.

A self-service kiosk with snacks and beverages, a refrigerated display, and a seating area with a view of the outside.

A modern bar area with a wooden counter, colorful bar stools, and a mural depicting Springfield.

An indoor swimming pool with clear water, surrounded by chairs and tables, and a sign indicating no lifeguard on duty.

20. Tru by Hilton Springfield Downtown

Downtown Springfield, 6.6 km from Lester E. Cox Medical Center South

jeff

￥16,442

￥18,747 total

includes taxes & fees

Nov 4 - Nov 5

View all properties

Compare top hotels near Lester E. Cox Medical Center South

Hampton Inn Springfield-South Galloway Village, 2 km from Lester E. Cox Medical Center South View	Holiday Inn Express and Suites Springfield Medical District by IHG 1.6 km from Lester E. Cox Medical Center South View	Homewood Suites by Hilton Springfield Medical District Southside, 1.4 km from Lester E. Cox Medical Center South View	Candlewood Suites Springfield-Medical District 0.9 km from Lester E. Cox Medical Center South View	Hilton Garden Inn Springfield, MO Lake Springfield, 2.7 km from Lester E. Cox Medical Center South View
9.4 Exceptional 721 reviews	9.4 Exceptional 1,000 reviews	9.4 Exceptional 570 reviews	9.2 Wonderful 436 reviews	9.0 Wonderful 882 reviews
￥16,683 ￥18,935 total includes taxes & fees Nov 1 - Nov 2	￥21,210 ￥24,075 total includes taxes & fees Nov 8 - Nov 9	￥20,637 ￥23,426 total includes taxes & fees Oct 30 - Oct 31	￥18,677 ￥21,198 total includes taxes & fees Nov 1 - Nov 2	￥18,041 ￥20,669 total includes taxes & fees Oct 31 - Nov 1

Top Lester E. Cox Medical Center South Hotel Reviews

MainStay Suites Springfield South - Battlefield Rd

10/10 Excellent

"easy peasy Thank You....."

Peaceful Retreat near Medical Mile in Springfield

10/10 Excellent

"We had a wonderful time and the house is very warm, welcoming and clean. Thank you."

Hampton Inn Springfield-South

10/10 Excellent

"easy peasy. thank you cya"

Element by Marriott Springfield South

10/10 Excellent

"Clean, all staff were helpful and friendly. Great place and I have no complain"

The Bradford Hotel, an Ascend Collection Hotel

8/10 Good

"Parking was convenient, but I had a ground level floor. The proximity to the medical clinics was an excellent resource. Breakfast was nice. Staff was helpful. I would recommend !"

Cozy Central Home by CoxHealth & MSU - Fenced Yard

10/10 Excellent

"We had a great stay. In town for a wedding reception, we arrived Friday afternoon and left Sunday morning. The house was clean, bright and spacious. The dog loved the back yard. Morning coffee on the deck in the shade of the weeping willow was relaxing."

Comfortable Home Near CoxHealth & MSU - Fenced Yard

10/10 Excellent

"The house was better than described, very comfortable and everything is right there I mean right there, I was pleasantly surprised on how I was able to get ot everything in no time flat, the only thing that was a hike was the airport."

Elevate Your Stay in Our Stunning Loft with 17-Foot Ceilings

10/10 Excellent

"Unique stay versus other rentals I’ve been too! Very modern, very safe feeling, comfy pillows, the COMFIEST blanket I’ve ever used and I wish I knew where they bought it everyone I talked with was hospitable and helpful with the minor bumps we had. Overall, it was perfect for our short get away!"

Frequently asked questions

What's the area like around Lester E. Cox Medical Center South?

Lester E. Cox Medical Center South is located in a welcoming area of Springfield that travelers like for its sporting events and opera houses. If you're looking for a convenient place to stay, check out the 19 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay close to Lester E. Cox Medical Center South?

Residence Inn by Marriott Springfield is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a restaurant. It's located just a short 0.5 mi (0.8 km) from Lester E. Cox Medical Center South. Other good choices close by include The Bradford Hotel, an Ascend Collection Hotel and Extended Stay America Select Suites Springfield South.

How many hotels are there close to Lester E. Cox Medical Center South?

Expedia has 19 hotels and other accommodations within a mile from Lester E. Cox Medical Center South.

If I need to cancel the hotel reservation for my stay near Lester E. Cox Medical Center South, will I receive a refund?

Yes, the majority of hotel room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the top deals on offer near Lester E. Cox Medical Center South.

Where can I learn more about changing or cancelling my trip in the area near Lester E. Cox Medical Center South?

For more information about picking new dates or cancelling your stay near Lester E. Cox Medical Center South, go to https://www.expedia.com/service/.

What can I see and do near Lester E. Cox Medical Center South?

You'll want to browse the exhibits at Springfield Art Museum and Discovery Center of Springfield. Sights like Abou Ben Adhem Shrine and Landers Theater highlight some of the local culture. You might spend a leisurely day outdoors at Nathanael Greene/Close Memorial Park and Mizumoto Japanese Stroll Garden.

Find hotels near Lester E. Cox Medical Center South, Springfield from ￥12,933

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Check prices for these dates

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Our top choices for Lester E. Cox Medical Center South hotels

1. Hampton Inn Springfield-South

2. Holiday Inn Express and Suites Springfield Medical District by IHG

3. Homewood Suites by Hilton Springfield Medical District

4. Candlewood Suites Springfield-Medical District

5. Hilton Garden Inn Springfield, MO

6. Residence Inn by Marriott Springfield

7. La Quinta Inn & Suites by Wyndham Springfield South

8. MainStay Suites Springfield South - Battlefield Rd

9. Comfort Inn South - Springfield

10. The Bradford Hotel, an Ascend Collection Hotel

11. Sleep Inn Springfield South I60 near Medical District

12. Extended Stay America Select Suites Springfield South

13. Clarion Pointe Springfield Southeast

14. Drury Inn & Suites Springfield, MO

15. Holiday Inn Express & Suites Springfield North by IHG

16. Hampton Inn Springfield-Southeast

17. SpringHill Suites by Marriott Springfield North

18. Fairfield Inn & Suites by Marriott Springfield North

19. Hotel Vandivort

20. Tru by Hilton Springfield Downtown

Compare top hotels near Lester E. Cox Medical Center South

Hampton Inn Springfield-South

Holiday Inn Express and Suites Springfield Medical District by IHG

Homewood Suites by Hilton Springfield Medical District

Candlewood Suites Springfield-Medical District

Hilton Garden Inn Springfield, MO

Top Lester E. Cox Medical Center South Hotel Reviews

MainStay Suites Springfield South - Battlefield Rd

Peaceful Retreat near Medical Mile in Springfield

Hampton Inn Springfield-South

Element by Marriott Springfield South

The Bradford Hotel, an Ascend Collection Hotel

Cozy Central Home by CoxHealth & MSU - Fenced Yard

Comfortable Home Near CoxHealth & MSU - Fenced Yard

Elevate Your Stay in Our Stunning Loft with 17-Foot Ceilings

Frequently asked questions