Find 5 Star Hotels in Hyannis, MA from ￥21,281

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Check availability on Hyannis 5 Star Hotels

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Dec 31 - Jan 1
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Jan 9 - Jan 11

Our top choices for Hyannis 5-star hotels

Seasonal outdoor pool
Chatham Bars Inn

Chatham Bars Inn

Chatham Bars Inn
5.0 star property
Chatham
9.2 out of 10, Wonderful, (802)
"Helpful staff & food & drinks were great ! "
United States
glen
The price is ￥68,338
￥82,123 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Chatham Bars Inn
Beach bar
Wequassett Resort and Golf Club

Wequassett Resort and Golf Club

Wequassett Resort and Golf Club
5.0 star property
Harwich
9.4 out of 10, Exceptional, (243)
"Great service and beautiful resort. "
United States
Kristopher
Wequassett Resort and Golf Club
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Hyannis.
Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod

1225 Iyannough Rd Hyannis MA
The price is ￥22,553 per night from Jan 4 to Jan 5
￥22,553
￥34,762 total
Jan 4 - Jan 5, 2026
includes taxes & fees
8.6/10 Excellent! (424 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Hyannis

Stroll the bustling harbor and hop aboard a ferry to Martha's Vineyard or Nantucket for a day trip. Visit the John F. Kennedy Hyannis Museum to learn about the president's connection to Cape Cod's summer playground.

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Hyannis showing a marina and a bay or harbor

Top Hyannis Hotel Reviews

Chatham Bars Inn

Chatham Bars Inn

10/10 Excellent
"The check in was wonderful. The Chatham Bars Inn was decorated so nicely for Christmas! There were so many families staying with their children and grandchildren. "
Marion 1-night trip
Posted 5 days ago
Chatham Bars Inn

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Hyannis?
You'll find a range of pricing options for a 5-star hotel in Hyannis on Expedia. How much you'll pay will depend on when you want to travel, length of stay and other factors. Compare all of the available accommodations for your preferred dates and make use of our pricing and other filters to find the perfect luxury stay.

  • Search for the lowest price per night from ￥21,281

What makes a hotel 5 stars in Hyannis?
Outstanding guest service is the hallmark of every 5-star hotel in Hyannis. From the minute you arrive, staff cater to your every whim, whether offering luggage assistance and storage or providing a turn-down service. Plus, hotels must offer top-rate amenities to meet the standard for a 5-star rating. These can include luxury bath products, an on-site spa, swimming pools, fine dining kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Hyannis?
Our handy filters are the best way to find exactly what you want. Select "All inclusive" and "5-star" to show the most luxurious hotels in Hyannis where your lodging, meals, activities and entertainment are included in the price. At these stays, your vacation is pure indulgence from the moment you put down your suitcase.