Find 5 Star Hotels in Florida Keys from ￥46,943

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Check availability on Florida Keys 5 Star Hotels

Our top choices for Florida Keys 5-star hotels

Balcony

Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,290 reviews)
"Breakfast was fantastic "
Canada
Craig
The price is ￥38,279
￥54,662 total
includes taxes & fees
Jan 29 - Jan 30
Cheeca Lodge & Spa
On the beach, sun loungers, beach umbrellas, beach towels

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,076 reviews)
"Great place! "
United States
Christine
The price is ￥60,217
￥78,154 total
includes taxes & fees
Jan 19 - Jan 20
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd Marathon FL
The price is ￥44,350 per night from Jan 29 to Jan 30
￥44,350
￥60,976 total
Jan 29 - Jan 30
includes taxes & fees
8/10 Very Good! (1,000 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys
Higgs Beach showing a sandy beach and tropical scenes as well as a large group of people

Top Florida Keys Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"The room was amazing.... Mahina was 5* dining The beach unfortunately do not plan to swim there or snorkel which is #1 for me personally to free swim and snorkel... The pools amazing.. Thr attention to detail and placment of amenities excellent except if you are in last building where volleyball is.. We dont eat sushi but it is not a restaurant, its just served on the beqch.. the marketplacd was a little too far of a walk next to the marina... bring your own coffee... the activities and games and daily texts were very informative... the burger bar food was excellent and large portions, except if you wanted a frozen cocktail.. they were not very good unfortunately if they were we would have stayed at main pool longer and they would have made more $$. The bar on beach was in a good location, but we didnt eat there, it closed early and wasnt many people there. even though the menu looked amazing... the bags, ping pong, life size games were cool.. the putting green was small and by marketplace... never seen anyone there.... need to have more tropical music playing at pools and around . The check in was fantastic and complimentary apple cider or champagne was a great touch.. Overall this place was amazing!! Would like yo see the beach dregged and able to swim.. "
Jennifer 5-night trip
Posted 4 days ago
Isla Bella Beach Resort & Spa
Cheeca Lodge & Spa

Cheeca Lodge & Spa

10/10 Excellent
"The room and the grounds were perfect. We can’t wait to go back."
Jeremiah 2-night trip
Posted 6 days ago
Cheeca Lodge & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
You can find several pricing options for a 5-star hotel in Florida Keys on Expedia. The amount you pay will depend on your travel dates, length of your trip and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to score the ideal upscale stay.

  • Search for the lowest price per night from ￥46,943

What makes a hotel 5 stars in Florida Keys?
From gourmet restaurants and 24-hour gyms to pools and deluxe bedding, the 5-star experience in Florida Keys is all about comfort and indulgence. But it calls for more than just top-notch perks to earn a 5-star rating. Stays must also provide outstanding guest-focused services like in-room massage treatments, on-site laundry and dry cleaning and 24/7 room service.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find an indulgent escape that includes your lodging, meals, drinks and entertainment in Florida Keys with Expedia's filters. Search for hotels rated 5 stars and click on the "All inclusive" filter. Double-check what's included in the upfront price. This way, you'll be ready to maximize all the premium perks from the moment you arrive.