Find 5 Star Hotels in Florida Keys from ￥57,131

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Check availability on Florida Keys 5 Star Hotels

Our top choices for Florida Keys 5-star hotels

Balcony

Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,315 reviews)
"Place was great!"
United States
Greg
The price is ￥40,440
￥57,131 total
includes taxes & fees
May 10 - May 11
Cheeca Lodge & Spa
On the beach, sun loungers, beach umbrellas, beach towels

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,119 reviews)
"All rooms have an ocean view-beautiful for sure!"
United States
Wanda
The price is ￥52,700
￥69,481 total
includes taxes & fees
May 3 - May 4
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Reefhouse Resort & Marina

Reefhouse Resort & Marina

103800 Overseas Hwy Key Largo FL
The price is ￥47,577 per night from Apr 23 to Apr 24
￥47,577
￥59,890 total
Apr 23 - Apr 24
includes taxes & fees
9.2/10 Wonderful! (1,404 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys

Top Florida Keys Hotel Reviews

Cheeca Lodge & Spa

Cheeca Lodge & Spa

6/10 Okay
"Booked premium beachfront king suite 40 days in advance. Confirmed the day before and when we got there we were given a double queen bed suite. Disappointed "
Stephen 1-night trip
Posted 1 day ago
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"I had an excellent experience at this hotel. Everything exceeded my expectations from start to finish. The staff was incredibly kind, welcoming, and always ready to help with anything we needed. The rooms were spacious, very comfortable, and impeccably clean, which made our stay even more enjoyable. Every area of the hotel was well-maintained and beautifully presented. Overall, everything about this place was outstanding. I would highly recommend it and would definitely love to come back."
Yunior 1-night trip
Posted 5 days ago
Isla Bella Beach Resort & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
You can find several pricing options for a 5-star hotel in Florida Keys on Expedia. The amount you pay will depend on your travel dates, length of your trip and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to score the ideal upscale stay.

  • Search for the lowest price per night from ￥59,890

What makes a hotel 5 stars in Florida Keys?
From gourmet restaurants and 24-hour gyms to pools and deluxe bedding, the 5-star experience in Florida Keys is all about comfort and indulgence. But it calls for more than just top-notch perks to earn a 5-star rating. Stays must also provide outstanding guest-focused services like in-room massage treatments, on-site laundry and dry cleaning and 24/7 room service.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find an indulgent escape that includes your lodging, meals, drinks and entertainment in Florida Keys with Expedia's filters. Search for hotels rated 5 stars and click on the "All inclusive" filter. Double-check what's included in the upfront price. This way, you'll be ready to maximize all the premium perks from the moment you arrive.