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Find hotels in Medical Center District, San Antonio from ￥8,187

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Discover 4,123 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Indoor pool
Drury Inn & Suites Near La Cantera Parkway
3.0 star property
9.4 out of 10, Exceptional, (1000)
"Great "
The price is ￥15,300
per night
May 21 - May 22
Drury Inn & Suites Near La Cantera Parkway
Exterior
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2134)
"The Omni La Mansión Hotel at the Riverwalk in San Antonio was a perfect venue for my husband and I to spend our 50th wedding anniversary at! The location was perfect, the staff is incredibly knowledgeable of their jobs and they’re kind and courteous as well. It’s an older hotel which has been well maintained and updates have been made over the years. Our room was pretty, well equipped with amenities and very comfortable. We had a narrow balcony through our French doors which opened to the street...
The price is ￥29,110
per night
Jun 16 - Jun 17
Omni La Mansion del Rio
Exterior
Drury Plaza Hotel San Antonio Riverwalk
3.0 star property
9.2 out of 10, Wonderful, (2591)
"Wonderful staff great location "
The price is ￥19,473
per night
May 21 - May 22
Drury Plaza Hotel San Antonio Riverwalk
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Terrace/patio
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.2 out of 10, Wonderful, (1262)
"We loved it ! "
The price is ￥29,560
per night
May 28 - May 29
Canopy by Hilton San Antonio Riverwalk
Free daily continental breakfast
La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB
2.5 star property
9.2 out of 10, Wonderful, (1022)
"It felt right at home. Thanks for another great stay."
The price is ￥14,494
per night
May 27 - May 28
La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB
Pillowtop beds, in-room safe, blackout drapes, iron/ironing board
Spark By Hilton San Antonio Northwest near Six Flags
3.0 star property
9.0 out of 10, Wonderful, (42)
"I enjoyed my 3 day stay and extended to 4. Very clean, the bed was comfortable but I have 1 complaint about the continental breakfast. The coffee (regular and decaffeinated) were ridiculously weak every day. Everything else was good. The breakfast area is so bright, clean and very pretty. Also, I know most people have cell phones to use for the time or alarms but I have never been in a hotel room that didn’t have a clock. That made it annoying to have to keep checking my phone. "
The price is ￥12,995
per night
May 22 - May 23
Spark By Hilton San Antonio Northwest near Six Flags
Lobby
Tru By Hilton San Antonio At The Rim, Tx
2.5 star property
9.0 out of 10, Wonderful, (514)
"Excellent hotel and great location "
The price is ￥15,824
per night
May 27 - May 28
Tru By Hilton San Antonio At The Rim, Tx
Outdoor pool, a heated pool, open 8:00 AM to 10:00 PM, free cabanas
Hotel Contessa
4.0 star property
8.8 out of 10, Excellent, (2734)
"Beautiful area, well cared for on the riverwalk. Saturday was very busy! We loved walking the riverwalk and seeing all the flowers and vegetation! Hotel was very nice and all employees very kind!"
The price is ￥26,955
per night
May 28 - May 29
Hotel Contessa
Miscellaneous
Grand Hyatt San Antonio River Walk
4.0 star property
8.8 out of 10, Excellent, (1065)
"convenient downtown location"
The price is ￥29,461
per night
May 27 - May 28
Grand Hyatt San Antonio River Walk
Exterior
Hilton Palacio Del Rio
4.0 star property
8.8 out of 10, Excellent, (1546)
"Great hotel! Always a pleasure staying here. Parking is pricey and currently road is under construction but still great hotel "
The price is ￥27,458
per night
May 29 - May 30
Hilton Palacio Del Rio
3 outdoor pools, cabanas (surcharge), sun loungers
Hyatt Regency Hill Country Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1002)
"Great service; hotel is pretty; but a little inconvenience about repairing "
The price is ￥43,803
per night
May 19 - May 20
Hyatt Regency Hill Country Resort & Spa
4 outdoor pools, cabanas (surcharge), pool umbrellas
JW Marriott San Antonio Hill Country Resort & Spa
4.5 star property
8.8 out of 10, Excellent, (1004)
"Such a relaxing resort. It offers so much for adults and children. We love visiting. "
The price is ￥59,291
per night
Jun 15 - Jun 16
JW Marriott San Antonio Hill Country Resort & Spa
Exterior
San Antonio Marriott Rivercenter on the River Walk
4.0 star property
8.8 out of 10, Excellent, (1002)
"Great Area!"
The price is ￥29,985
per night
May 26 - May 27
San Antonio Marriott Rivercenter on the River Walk
Lobby
Aloft San Antonio UTSA Area
3.0 star property
8.8 out of 10, Excellent, (548)
"Very nice property "
The price is ￥12,983
per night
May 19 - May 20
Aloft San Antonio UTSA Area
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 star property
8.6 out of 10, Excellent, (2997)
"Breakfast was great, room & common areas were clean. The front desk staff were all very friendly & helpful. "
The price is ￥14,714
per night
May 19 - May 20
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Restaurant
Element San Antonio Riverwalk
4.0 star property
8.6 out of 10, Excellent, (238)
"Simple design and very clean!"
The price is ￥17,620
per night
May 22 - May 23
Element San Antonio Riverwalk
Outdoor pool, sun loungers
Home2 Suites by Hilton San Antonio Riverwalk, TX
3.0 star property
8.6 out of 10, Excellent, (1004)
"Great hotel to stay in, while visiting the River Walk."
The price is ￥19,813
per night
May 27 - May 28
Home2 Suites by Hilton San Antonio Riverwalk, TX
Pool
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3.0 star property
8.4 out of 10, Very Good, (1317)
"Easy check in/out"
The price is ￥16,199
per night
Jun 2 - Jun 3
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Meeting facility
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
3.0 star property
8.4 out of 10, Very Good, (1482)
"It was nice and clean beautiful view from window"
The price is ￥19,335
per night
May 29 - May 30
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
Terrace/patio
AC Hotel by Marriott San Antonio Riverwalk
4.0 star property
8.4 out of 10, Very Good, (229)
"Room very clean, great location "
The price is ￥18,856
per night
May 29 - May 30
AC Hotel by Marriott San Antonio Riverwalk
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Other neighborhoods around Medical Center District

Hotels in top San Antonio neighborhoods Learn more about Medical Center District
Downtown - Riverwalk which includes heritage architecture, boating and a river or creek

Downtown San Antonio

3 out of top 10 points of interest in this area
4/5(9,525 area reviews)

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Find hotels in Downtown San Antonio

Medical Center District hotels information

Number of reviews
27,982
Accommodation
4,123 hotels
Lowest Price
￥8,187
Highest Price
￥58,586

Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Fairfield Inn & Suites by Marriott San Antonio Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and free parking. Other favorite options in the area include Atria Inn & Suites and Courtyard by Marriott Medical Center San Antonio.

How many hotels will I be able to find in Medical Center District?

Expedia has 127 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.

Recent reviews of Medical Center District hotels

Hotel Gibbs Downtown Riverwalk

Hotel Gibbs Downtown Riverwalk

5/5 Excellent
"Very nice hotel!"
A verified traveler stayed at Hotel Gibbs Downtown Riverwalk
Posted 8 hours ago
Hotel Gibbs Downtown Riverwalk