We enjoyed our stay in NYC and at the Hampton South Manhattan location. Like other reviews, the rooms have very limited walking space, but that is to be expected in the NYC highrises. The elevator lines were long a few times, during peak times, but they moved fast and was not a problem; it just required practicing a little patience.
We had some issues with housekeeping coming in when we had "do not disturb" door hanger up and walking in without warning at 5:30pm. Next time we would just keep the latch attached on the door while inside at all times.
Breakfast was busy, but a well-oiled machine. Staff was present, keeping food area clean and full, immediately cleaning tables when they were unoccupied so others could sit quickly.
Subway was a 2-3 block walk. We felt safe. There is a nice little pub next day, The Joyce Public House, which we went to two nights when it was storming really bad and we did not want to venture too far out.