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Compare 195 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

2 outdoor pools
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
8.8 out of 10, Excellent, (284)
"Hotel is great. Service is better. Rooms by the pool, which should be the centerpiece of the property, are a bit dated. Bed was just ok. Comfortable enough but not great. "
The price is ¥21,824
per night
May 31 - Jun 1
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Front of property - evening/night
Hotel LP Equipetrol
3.5 star property
8.2 out of 10, Very Good, (185)
"The property is good. My only problem was the wifi which in my room was very poor and in other areas very slow."
The price is ¥13,057
per night
May 25 - May 26
Hotel LP Equipetrol
Property amenity
Marriott Santa Cruz de la Sierra Hotel
5.0 star property
8.8 out of 10, Excellent, (147)
"Clean comfortable room and beds. Nice fitness center. Small pool and hot tub could be hotter. Munimal vegan options at restaurant but lots of other places nearby. "
The price is ¥17,305
per night
Jun 7 - Jun 8
Marriott Santa Cruz de la Sierra Hotel
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Front of property
Camino Real Hotel
4.5 star property
8.8 out of 10, Excellent, (327)
"Excelente hotel, muy confortable. Lo único malo es que no se puede desayunar con la ropa que saldrás al trabajo, hay mucho olor a comida en el restaurante y se queda en la ropa."
The price is ¥18,183
per night
May 30 - May 31
Camino Real Hotel
Breakfast, lunch and dinner served
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
9.2 out of 10, Wonderful, (194)
"It’s an awesome place. Location couldn’t be better. Restaurants, cafes, shopping all within walking distance. Neighborhoods to walk around a get to know. Easy transportation to historic downtown and very reasonable cost. "
The price is ¥13,998
per night
May 30 - May 31
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Outdoor pool, free cabanas
TRYP by Wyndham Santa Cruz
4.0 star property
9.4 out of 10, Exceptional, (77)
"We didn’t arrive until 5:00am and they kept our room available for our late arrival. Staff was A ! Highly recommend and will stay there again."
The price is ¥9,923
per night
Jun 1 - Jun 2
TRYP by Wyndham Santa Cruz
Standard Double Room, 1 King Bed | Bathroom | Shower, free toiletries, towels, soap
Hotel G
3.5 star property
7.8 out of 10, Good, (89)
"Everything was great. Only down side was the construction being infront of the hotel. But the location is good area. "
The price is ¥7,271
per night
May 26 - May 27
Hotel G
Outdoor pool, open 9:00 AM to 8:00 PM, sun loungers
Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
9.2 out of 10, Wonderful, (60)
"Great service. Very nice and accommodating staffs "
The price is ¥8,355
per night
May 28 - May 29
Premium Suites Deluxe Aparthotel Equipetrol
Lobby sitting area
Novotel Santa Cruz De La Sierra
5.0 star property
9.2 out of 10, Wonderful, (63)
"Nice hotel, clean, modern and very comfortable. Nice view. The best option for a solo traveler or business trip in Santa Cruz"
The price is ¥12,109
per night
Jun 4 - Jun 5
Novotel Santa Cruz De La Sierra
Outdoor pool
Sun Hotel
3.5 star property
8.4 out of 10, Very Good, (244)
"This property is great if you need proximity to the airport. I arrived on a late evening flight and was flying back out in the morning. The shuttle service was very accommodating, waiting for me while I got my tourist visa. "
The price is ¥19,045
per night
May 29 - May 30
Sun Hotel
Sports facility
Ibis Santa Cruz DE LA Sierra
3.0 star property
9.8 out of 10, Exceptional, (26)
"I had a great stay at this hotel. It has a good location, within reasonable walking distance to the old town or the restaurant area, though Uber is very easy and cheap. The hotel is good, modern and clean . The ambience is very quiet , I would have liked a more interesting and lively vibe. The room was very spacious and comfortable. The only downside was that my room did not have a mini-fridge. The front desk staff was very helpful and kind. "
The price is ¥10,174
per night
Jun 8 - Jun 9
Ibis Santa Cruz DE LA Sierra
Executive Apartment | Premium bedding, down comforters, pillowtop beds, in-room safe
Fiori Apartment
3.5 star property
9.2 out of 10, Wonderful, (70)
"Really nice and confirtable"
The price is ¥5,640
per night
May 25 - May 26
Fiori Apartment
Property entrance
Hotel Cortez
3.5 star property
9.0 out of 10, Wonderful, (72)
"Great hotel. The service was outstanding. The room was very clean and nice. It looks just like the pictures. The included breakfast was delicious"
The price is ¥18,684
per night
May 25 - May 26
Hotel Cortez
Massages
Swissôtel Santa Cruz De La Sierra
4.5 star property
9.0 out of 10, Wonderful, (41)
"Good"
The price is ¥14,781
per night
Jun 4 - Jun 5
Swissôtel Santa Cruz De La Sierra
Standard Room, 2 Twin Beds | Premium bedding, minibar, in-room safe, desk
Hotel LP Santa Cruz Centro
3.0 star property
7.8 out of 10, Good, (273)
"Best 👍"
The price is ¥8,046
per night
May 25 - May 26
Hotel LP Santa Cruz Centro
Terrace/patio
Hostal Killa
3.0 star property
The price is ¥3,462
per night
May 25 - May 26
Hostal Killa
Reception
HOTEL OSHO
3.5 star property
8.6 out of 10, Excellent, (18)
"I like his service "
The price is ¥10,950
per night
Jun 5 - Jun 6
HOTEL OSHO
Room
Delfines Collection Hotel By Mercure
3.5 star property
8.2 out of 10, Very Good, (20)
"Buena ubicación. Personal amable. Lugar tranquilo. Habitaciones confortables. "
The price is ¥6,043
per night
Jun 7 - Jun 8
Delfines Collection Hotel By Mercure
Reception
Alojamiento Oasis
2.5 star property
6.4 out of 10, (5)
"Nadie fue cordial. Había mucho ruido "
The price is ¥2,041
per night
May 25 - May 26
Alojamiento Oasis
Standard Suite | Hypo-allergenic bedding, down comforters, desk, laptop workspace
Equipetrol Suites Apart Hotel
2.5 star property
6.0 out of 10, (2)
"Habian bichos en la habitacion, sabanas con manchas, en general no muy bueno."
The price is ¥6,915
per night
Jun 5 - Jun 6
Equipetrol Suites Apart Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Santa Cruz hotels information

Number of reviews
59
Accommodation
195 hotels
Lowest Price
¥2,041
Highest Price
¥21,824

Frequently asked questions

What's the best place for a stay in Santa Cruz?

Alfonsina Hotel Boutique by Inboccaluppo is a favorite with Expedia customers. This hotel offers free breakfast and a restaurant. Reviews from our site also recommend TRYP by Wyndham Santa Cruz and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia as top options for your trip. See all available top hotels, or vacation rentals in Santa Cruz.

What's the top vacation rental that Santa Cruz has to offer?

Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Make the most of the private yard in this rental home to help you unwind. Some other homes for rent in Santa Cruz include Mi casa su casa, moderna y chic. and Cozy and independent.
Downtown house JH.
. See all vacation rentals in Santa Cruz.

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?

Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.

Where can I learn more about changing or cancelling my trip to Santa Cruz?

To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.

What's the best budget-friendly accommodation in Santa Cruz?

Based on our traveler reviews, Hostal Killa is a top choice for a less expensive stay. Other choices for your budget-friendly stay include residencial francia - Hostel and Residencial Ikandire II. View all budget hotels in Santa Cruz.

What's the best accommodation for a family trip to Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a hotel with an outdoor pool and a restaurant, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Camino Real Hotel. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.

What's the best place to stay for a romantic vacation to Santa Cruz?

Buganvillas Hotel Suites & Spa is a favorite 4-star hotel for couples, and features in-room massages and rainfall showerheads. See all romantic hotels in Santa Cruz.

What is the top LGBTQ-friendly accommodation in Santa Cruz?

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santa Cruz.

What's the best pet-friendly hotel in Santa Cruz?

Hotel LP Equipetrol is a top hotel for people traveling with their pets, and offers a restaurant and concierge services for its human guests. Other good options for you and your pet's trip include Ibis Santa Cruz DE LA Sierra and Swissôtel Santa Cruz De La Sierra. See more pet-friendly hotel accommodations in Santa Cruz.

Where is the best place to stay close to Plaza 24 de Septiembre?

Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.

What about the best place to stay near Ventura Mall?

One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.

What's the best luxury accommodation in Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.

Recent reviews of Santa Cruz hotels
Expedia verified reviews